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Biomedical subjects

J Harrison

Publications and source records attributed to J Harrison.

At least 307 records · Page 17Linked to original sources
PubMed1966

The effect of sodium alginate on the absorption of strontium and calcium in human subjects.

The effect of sodium alginate on the gastrointestinal absorption of the tracers strontium-85 and calcium-47 was investigated in 19 human subjects. The tracers were administered orally with 100 mg. of a calcium carrier-calcium chloride. At the same time, sodium alginate was given in a commercial jelly. The sevenday per cent retentions of tracers were measured with a whole-body counter. After one month, the experiments were repeated without alginate so that each subject acted as his own control. Fifteen volunteers were given 1.5 g. of alginate, two were given 3.0 g. and two 0.3 g. 1.5 g. of alginate reduced the absorption of strontium by a factor of two with no significant effect on calcium absorption. The smaller dose of alginate (0.3 g.) appeared to have no effect on strontium or calcium absorption and the larger dose (3.0 g.) had no greater effect than the 1.5 g. dose.

Alginates↗
PubMedDate not supplied

Palliative therapy of malignant esophageal stricture with the bipolar tumor probe and prosthetic tube.

Patients with malignant esophageal stricture and dysphagia were prospectively randomized to receive palliative therapy with the bipolar tumor probe (17) or prosthetic tube insertion (13). Both treatments gave good relief of dysphagia compared with pretreatment values on a dysphagia score, the results being statistically significant (p less than 0.005). However, there was no difference in the improvement achieved by one method compared with the other. The tumor probe was not difficult to use and complication rates were comparable. In the Atkinson tube group, two patients developed complications related to the position of the prosthesis and in three others food blocked the tube. Treatment with the tumor probe needed repeating at intervals (median, 28 days; range, 2 to 86 days) in all but four individuals to maintain palliation, with each patient needing a median of two treatments (range, 1 to 8). The probe may have advantages in very high esophageal lesions and may facilitate the treatment of tumor overgrowth or undergrowth of a tube. The prosthetic tube may give long-lasting relief of dysphagia and remains the treatment of choice for bronchopulmonary fistulas.

Adenocarcinoma↗
PubMedDate not supplied

A novel, resorbable suture anchor: pullout strength from the human cadaver greater tuberosity.

The pullout strength of a collagen bone anchor that creates interference fixation as the result of radial swelling on hydration was compared with a Mitek rotator cuff anchor after insertion into the greater tuberosity of human cadaver humeri. Bones were fully hydrated at 37 degrees C. Stiffness, peak load, and the mode of failure were recorded. Real and apparent bone densities were measured. Peak load for the collagen anchor at 15 minutes (121.0N +/- 81.3N) was greater than at 2 minutes (60.5N +/- 38.5N) after insertion (P <.05). At between 5 and 60 minutes after insertion, peak loads for the Mitek and the collagen anchors did not differ. After 30 minutes from insertion, the mode of failure of the collagen anchor changed from pullout with minor body damage to pullout with major body damage. Peak load at pullout correlated with bone density for the Mitek (P <.05, r = 0.516) but for the collagen bone anchor appeared unaffected by bone density.

Aged↗