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Biomedical subjects

J Harper

Publications and source records attributed to J Harper.

At least 145 records · Page 8Linked to original sources
PubMed1980

Platelet factor 4 regulates osteoclastic bone resorption in vitro.

Platelet factor 4, which inhibits collagenases derived from both human skin and granulocytic extracts, was found to block reversibly parathyroid hormone-stimulated 45Ca release from fetal rat bone in vitro. The inhibitory property was equally effective in both actively resorbing bones and in bones stimulated to initiate resorption.

Animals↗
PubMed1980

An assessment of the clinical effects of reporting accident and emergency radiographs.

A prospective study of the accuracy of interpretation of radiographs by casualty officers and radiologists is presented. The casualty officers readings were correct in 83% of cases, and the radiologists' in 95%. There was agreement of interpretation in 83% of the examinations. This study indicates that there are clinical and economic benefits when the radiologist's report is available before the patient leaves the hospital. Delayed reporting of films is considered to be less satisfactory but is still of value as it increases the detection of clinically significant abnormalities and also clarifies most of the 10% of studies about which the casualty officer is uncertain. Where a delayed reporting system is practised, a25% reduction in radiologist's workload would be achieved by reporting only those films considered by the casualty officer to be "normal" or "uncertain". Attempts to reduce workload still further by not reporting any films will increase the number of patients poorly managed in casualty.

Emergency Service, Hospital↗
PubMed1979

Reasons for requesting radiographs in an accident department.

A prospective study of 500 patients was performed to determine the reasons for requesting radiographs in an accident and emergency department. Most examinations were requested either to confirm a clinically suspected abnormality or because of difficulty in excluding a significant bone injury on clinical grounds alone. Several requests were also made to reassure the patient. Medicolegal reasons were relatively few, and those made purely because the doctor feared litigation probably accounted for only 5% of requests. Undue emphasis on the medicolegal aspects of accident and emergency radiography in the United Kingdom is unhelpful in that it directs attention away from the real reasons for x-ray referral. Although a reduction in the number of x-ray examinations is desirable on the grounds of expense and radiation exposure it is likely to be obtained only by improving experience and acumen in the clinical assessment of injuries.

Clinical Competence↗
PubMed1979

Depression in childhood. 1: Clinical correlates of depressed children admitted for treatment to a residential program.

Ninety-three children with a diagnosis of depression were admitted to a residential children's unit over a six-year period. Background and clinical data were analysed in order to identify correlates associated with the disorder and to examine the concept of 'depressive equivalents'. The results indicated that parental loss, particularly loss of father, through death or desertion, psychiatric illness in the parents and stressful events in early childhood were important concomitants of the disorder. The study also supported the current literature on 'depressive equivalents' and their expression in childhood.

Adjustment Disorders↗
PubMed1976

Impact of a district branch Task Force on women.

A questionnaire sent to all women psychiatrists and trainees in North Carolina as part of the development of a district branch Task Force on Women indicated that institutional sexism affects the careers of many of the respondents. Problems of family-professional role conflicts were especially pronounced in residents and faculty women. Survey findings have resulted in recommendations in the areas of education, communication, and increasing women's participation in task force and district branch activities. The authors feel that such task forces provide a much needed network of supportive relationships for women psychiatrists and raise the consciousness of the district branch regarding women's issues.

Attitude of Health Personnel↗
PubMed1975

Age and type of onset as critical variables in early infantile autism.

A retrospective study of 131 autistic children was made in which 2 groups, Natal and Acquired, were defined on the bases of age at onset and type of onset. Prenatal and perinatal variables were found to be significantly related to Natal onset, whereas in the Acquired group the significant variables were those occurring in early childhood, between years 1 and 3. Follow-up data on intellectual functioning and language development indicated a better prognosis for the Acquired group. An inability to cope with stress is postulated as an underlying feature in both instances, present from birth in the Natal group and occurring in the face of developmental stresses in the Acquired group.

Adaptation, Psychological↗