Biomedical subjects
Publications and source records attributed to J Haratake.
A 78-year-old man with pancreatic carcinoma with carcinoid tumor of the appendix is reported. Upon autopsy, the tumor consisted of poorly differentiated adenocarcinoma with scirrhous-like spreading. In the appendix a carcinoid tumor, size measuring 2 mm X 1 mm, was seen; the carcinoid cells were argentaffin.
Unusual nodules of hyperplastic hepatocytes were found in the liver of a 64-year-old woman with non-cirrhotic portal fibrosis (idiopathic portal hypertension). These nodules were subdivided by stellate fibrous tissues which, in the center of the nodules, contained conspicuous telangiectatic lesions with congestion. The latter was consisted of markedly dilated sinusoids and fibrosis of their walls either in a lack of hepatocytes or with severly atrophic hepatic column. The lesions were different from already described focal nodular lesions in the liver. No drugs and chemicals could be identified as the causative agents. The small arterial changes, namely, hyalinization and thickening of their walls and luminal narrowing or occlusion, were found in the nodular lesions and also in the remaining hepatic tissues, and might be a causative factor for the nodular lesions.
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Explore the source record for details and available documents.
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This study reports the biological half-time of amorphous nickel monosulfide(NiS(A)) aerosol retained in rat lungs. Wistar male rats were exposed to NiS(A) aerosols (mass median aerodynamic diameter:4.0 microns) for a single 4 h exposure, or for 7 h/d, 5 d/wk for 1 mo. The average exposure concentrations were controlled at 107 mg/m3 for the single exposure and at 8.8 mg/m3 for the repeated exposures by a dust generator consisting of a continuous fluidized bed with an overflow pipe and a screw feeder. After the exposures, the nickel contents in the rat organs, blood, and urine were measured and histopathological examinations were performed. The biological half time of NiS(A) in rat lungs was 20 h, which was extremely shorter than 21 mo of green nickel oxide (NiO(G)). There were no malignant tumors in any of the exposure groups.
Globular filamentous bodies are one of the well-known inclusion bodies in hepatocellular carcinoma. The article describes a 56-year-old man with an occult hepatocellular carcinoma in whom the first histologic diagnosis was made from a biopsy from bone. Ultrastructural examination showed many globular filamentous bodies similar to Mallory bodies. The ultrastructural findings and the diagnostic value of these filamentous bodies are discussed.