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Biomedical subjects

J Harari

Publications and source records attributed to J Harari.

17 recordsLinked to original sources
PubMed1995

Surgical treatments for prostatic diseases in dogs.

Successful prostatic surgery requires aggressive perioperative animal patient management, accurate identification of the disease process, and proper surgical techniques. Overcoming the complications associated with urinary incontinence, sepsis, and neoplasia will help reduce animal patient morbidity and mortality.

Animals↗
PubMed1992

Scintigraphic evaluation of tissue viability after gunshot injury in a dog.

Triple-phase bone scintigraphy was used to evaluate tissue viability in the forelimb of a dog after gunshot injury. This technique was reliable, noninvasive, and easily performed. It was used to complement radiography by providing functional, rather than structural, assessment of tissues on the basis of regional vascular patterns. In this dog, vascular impairment caused by trauma appeared as photopenic or "cold" spots during immediate (vascular), soft tissue and bone phases of the scintigraphic study. On the basis of gross morphologic and scintigraphic findings, forelimb amputation was performed.

Amputation, Surgical↗
PubMed1992

Complications of external skeletal fixation.

Complications associated with ESF can deleteriously affect soft tissue and bone healing. Adherence to proper surgical techniques and guidelines will minimize development of ESF-related complications. The most common problems associated with ESF are pin tract infections, fixator problems, and soft tissue impalement. These complications can be avoided by using proper pin insertion techniques that reduce skin tension; pin-bone, pin-skin motion; and soft tissue trauma. In addition, proper selection of pins (size, threaded or smooth), fixator configuration, ancillary implants, and a cancellous bone graft further reduce the risk of complications and inadequate healing.

Animals↗
PubMed1992

Surgical treatments for intervertebral disc disease.

Surgical treatments for intervertebral disc disease are useful for animals with gradually progressive, severely acute, or recurrent lesions. Surgical patients require a diligent neuroradiographic evaluation to confirm location and severity of the discopathy and rule out conditions unrelated to disc disease. Although controversial, some surgeons advocate fenestration for recurrent pain or mild ataxia associated with a noncompressive lesion. Decompressive procedures are recommended for treatment and prognostication of compressive disc-associated myelopathy. Foraminotomy is reserved for patients with lateralizing extrusions confirmed with myelography or newer imaging modalities (CT, MRI). Future treatments for animals may include chemonucleolysis or various discectomy procedures currently performed in humans with symptomatic disc disease.

Animals↗
PubMed1991

Cardiovascular effects of halothane anesthesia after diazepam and ketamine administration in beavers (Castor canadensis) during spontaneous or controlled ventilation.

Fourteen adult beavers (Castor canadensis) weighing 16.5 +/- 4.14 kg (mean +/- SD) were anesthetized for surgical implantation of radio telemetry devices. Beavers were anesthetized with diazepam (0.1 mg/kg) and ketamine (25 mg/kg) administered IM, which provided smooth anesthetic induction and facilitated tracheal intubation. Anesthesia was maintained with halothane in oxygen via a semiclosed circle anesthetic circuit. Values for heart rate, respiratory rate, esophageal temperature, direct arterial blood pressure, end-tidal halothane concentration, and end-tidal CO2 tension were recorded every 15 minutes during the surgical procedure. Arterial blood samples were collected every 30 minutes to determine pH, PaO2, and PaCO2. Values for plasma bicarbonate, total CO2, and base excess were calculated. Ventilation was spontaneous in 7 beavers and controlled to maintain normocapnia (PaCO2 approx 40 mm of Hg) in 7 others. Vaporizer settings were adjusted to maintain a light surgical plane of anesthesia. Throughout the surgical procedure, all beavers had mean arterial pressure less than 60 mm of Hg and esophageal temperature less than 35 C. Mean values for arterial pH, end-tidal CO2, PaO2, and PaCO2 were significantly (P less than 0.05) different in spontaneously ventilating beavers, compared with those in which ventilation was controlled. Respiratory acidosis during halothane anesthesia was observed in spontaneously ventilating beavers, but not in beavers maintained with controlled ventilation. All beavers recovered unremarkably from anesthesia.

Acid-Base Equilibrium↗
PubMed1986

Clinical and pathologic features of thyroid tumors in 26 dogs.

Thyroid tumors were diagnosed in 26 dogs between 1977 and 1984. A total of 23 of the 26 tumors were carcinomas, and 3, detected as incidental findings at necropsy, were adenomas. The median patient age was 9.5 years. Dogs of the Beagle breed were affected most commonly (5 dogs). The most common physical abnormalities in carcinoma patients were cervical swelling, dyspnea, and coughing. A total of 25 of 26 dogs were clinically euthyroid. Aspiration cytology provided diagnostic information in 8 of 17 cases. In dogs with thyroid carcinoma, a cervical soft tissue lesion was identified consistently by use of radiography and scintigraphy with sodium pertechnetate. Pulmonary metastases were detected radiographically in 8 of 21 dogs with thyroid carcinoma. Thoracic nuclear imaging confirmed the radiographic findings in 11 of 14 dogs. Surgical excision of the thyroid mass was the primary treatment for 17 dogs with carcinoma. Eight dogs died within 2 years (median, 7 months) of surgery because of primary tumor regrowth or metastases. Four dogs were alive at a range of 3 to 48 months after surgery, and 4 dogs died from unrelated causes. Necropsy of 7 dogs with thyroid carcinoma revealed neoplastic infiltration of the cervical blood vessels and pulmonary metastases in each dog. The most common histologic patterns of thyroid carcinoma were solid or compact cellular (11 dogs) and mixed solid-follicular tumors (8 dogs). Dogs with a solid carcinoma had a median survival time of 10.5 months (6 dogs), and dogs with a mixed solid-follicular tumor had a median survival time of 8 months (3 dogs).

Adenoma↗
PubMed1984

Osteomyelitis.

Osteomyelitis can be diagnosed by clinical, radiographic, and bacteriologic evaluation of the patient. An aggressive medical approach utilizing appropriate bactericidal antibiotics is required, along with surgical intervention in chronic cases.

Animals↗
PubMed1978

Electronic cell volume analysis of growth and rejection of EL-4 ascites tumor cells.

The in vivo growth of EL-4 ascites tumor cells in peritoneal cavities of syngeneic (C57BL/6) and allogeneic (DBA/2) mice was monitored by electronic volume analysis. In the growth of EL-4 cells in the C57BL/6 mice, daily decrease in electronic modal cell volume and labeling indices was observed. After day 7, the rejection of EL-4 cells in DBA/2 mice was indicated by increase in the percentage of small cytotoxic lymphocytes and decrease in the labeling indices of tumor cells.

Animals↗
PubMedDate not supplied

Evaluation of experimental transection and partial excision of the caudal cruciate ligament in dogs.

The caudal cruciate ligament (CaCL) of one stifle joint in seven dogs was transected and a 2 to 4 mm section was removed. Six months after surgery, none of the dogs were lame. Thigh muscle circumference, stifle range of motion, and internal tibial rotation in the operated limb were not significantly different from the preoperative measurements or the contralateral, unoperated limb. A caudal drawer motion was consistently present in the stifle joints with a transected CaCL. A radiographic evaluation of the operated stifle joints did not reveal osteoarthritic changes; four of seven stifle joints had an irregular fat pad 6 months after surgery. Results of a joint fluid analysis revealed a slight increase in synovial cells within treated stifle joints; inflammatory cells were not observed. The only gross morphologic change in stifle joints with a severed ligament was enlarged knobby remnants of the CaCL. Articular cartilage defects or osteophytes were not observed. Results of a histologic examination of the CaCL remnants revealed synovial cellular capping and intraligamentous fibroplasia. Based on a limited number of dogs, it was concluded that isolated transection of the CaCL produced minimal clinical and pathologic changes in the stifle joint during a 6 month period.

Animals↗
PubMedDate not supplied

Evaluation of the lateral collateral ligament after fibular head transposition in dogs.

Cranial transposition of the fibular head stabilizes the stifle joint by displacing the distal attachment of the lateral collateral ligament (LCL). The forces applied to the LCL after displacement may cause ligamentous elongation. This investigation evaluated the morphological, histological, and biomechanical changes of the LCL after fibular head transposition (FHT) in dogs. Unilateral cranial cruciate ligament (CCL) excision and FHT were performed on 25 dogs. Cross-sectional area, length, histological, and structural properties of the LCL were evaluated 3 weeks, 4 months, and 10 months after surgery. Ligament length means were significantly increased at week 3, month 4, and month 10 compared with intraoperative length means. No significant changes in elongation were observed after week 3. Fibrovascular proliferation within the LCL increased the cross-sectional area and associated structural properties.

Animals↗