Search PubMed⌕ Search

Biomedical subjects

J Hara

Publications and source records attributed to J Hara.

At least 145 records · Page 8Linked to original sources
PubMed1986

Volume regulation in leukemic and lymphoma cells in children and determination of cell lineage.

Among normal lymphocytes, T cells can readjust their volume rapidly following initial swelling in a hypotonic medium, whereas B cells do not have this ability. Based on this finding, we examined the volume regulation of malignant cells from 40 patients with lymphocytic and nonlymphocytic malignancies. The T lineage cells were able to regulate their volume in response to hypotonic stress, whereas B lineage cells were not able to do so. In contrast to lymphoid lineage cells, nonlymphocytic leukemia cells as well as undifferentiated cells did not show a consistent tendency in their volume regulation. These results showed that the difference in the ability to regulate cell volume in response to hypotonic stress is available as a marker for identifying the cellular lineage of lymphoid malignancies.

Acute Disease↗
PubMed1985

[Changes of peripheral lymphocyte subsets in patients with oral squamous carcinoma].

The distribution of peripheral lymphocyte subsets of 32 patients, who had undergone surgical removal of squamous carcinoma and have evaded recurrence was studied using OK series monoclonal antibodies. The T-lymphocyte subpopulation was reduced in patients who were tumor free for more than 3 years. The helper/inducer T-cell subpopulation was reduced in most of the patients studied, whereas little change was observed in the subpopulation of suppressor/cytotoxic T cells. Consequently the ratio of OKT 4+/OKT 8+ was reduced in accordance with the tumor free period.

Adult↗
PubMed1985

[Study on the transfer of cefroxadine to human tears].

A comparative study to determine the transfer of cefroxadine (CXD), an oral cephem antibiotic, to the human tears was undertaken using cephalexin (CEX) as the control drug. The mean tear levels of 250 mg each of CXD and CEX after oral administration in 6 volunteers were equally peaked at 0.26 micrograms/ml with CXD after 1 to 2 hours and with CEX after 2 hours. The changes of tear levels were also equal for both drugs. The ratios between the tear and the blood levels at 2 hours after oral administration were almost equal with 4.1% for CXD and 3.7% for CEX. From the above evidence it has been confirmed that the both drugs were equivalent with regard to the concentration profiles in human tears after oral medication.

Administration, Oral↗
PubMed1984

Skin test with varicella-zoster virus antigen for ophthalmic herpes zoster.

We assessed delayed dermal hypersensitivity to varicella-zoster virus by a varicella skin test in 12 patients (nine women and three men ranging in age from 27 to 85 years) with ophthalmic herpes zoster during the acute stage and in a group of 27 healthy controls (15 women and 12 men ranging in age from 18 to 58 years). Of the 27 healthy individuals, 25 had positive skin test reactions whereas only one of the 12 patients with ophthalmic herpes zoster had a positive skin test reaction within two weeks after the onset of the eruption, suggesting that cellular immunity to varicella-zoster virus antigens is impaired in the development of ophthalmic herpes zoster. Our study also showed that the varicella skin test is a convenient way to diagnose ophthalmic herpes zoster during the acute stage of the disease.

Adolescent↗
PubMed1984

[Successful chemotherapy for mediastinal seminoma--a case report].

A case with large primary mediastinal seminoma responded very well to chemotherapy. A 13-year-old boy was evaluated for complaints of edematous face and neck. Chest radiography and computerized tomography revealed a large anterior superior mediastinal mass. Needle biopsy demonstrated seminoma. After two-drug combination chemotherapy with vincristine and prednisolone and three-drug combination with vincristine, prednisolone and cyclophosphamide, there was a considerable regression of the mediastinal mass. The lower neck and mediastinum were irradiated at a dose of 3,750 rad after cessation of chemotherapy. The patient has been asymptomatic without evidence of recurrence for a follow-up period of more than four years.

Adolescent↗
PubMed1983

[Clinical evaluation of cefroxadine in bacterial infections of the eye].

Cefroxadine (CXD) capsules and dry syrup, an oral cephem antibiotic, were administered into 120 cases with ocular infections and the following results were obtained: The daily dose of CXD capsule was ranged from 500 to 1,500 mg and that of CXD dry syrup from 17.9 to 85.7 mg/kg, and the duration of CXD administration was from 2 days to 14 days. Clinical response rates classified by diagnosis The clinical response rates were 77.8% (14/18) in blepharitis, 86.7% (26/30) in hordeolum, 62.5% (5/8) in meibomianitis, 74.6% (44/59) in conjunctivitis, 100% (2/2) in corneal infiltration, 100% (1/1) in cellulitis of the lid, in dacryocystitis and in corneal ulcer, respectively. Clinical response classified by isolated organisms The response rates on S. aureus were 80.0% (20/25), on S. epidermidis 75.8% (47/62) and on S. pneumoniae 66.7% (2/3), respectively. The overall clinical response rate on Gram-positive bacteria was 78.3% (94/120). The response rates on H. influenzae, Acinetobacter spp., P. mirabilis, E. coli and Moraxella spp. were ranged from 42.9 to 100%. The sensitivity distributions of clinically isolated S. aureus and S. epidermidis to CXD were ranged from 1.56 to greater than 100 micrograms/ml and from 0.39 to 12.5 micrograms/ml, respectively. The former showed a peak at 3.13 micrograms/ml and the latter in 1.56 micrograms/ml. Side effects in 3 cases (2.3%) out of 129 were observed. That is; glossitis, thirst feeling and palpitation in each case, respectively.

Administration, Oral↗