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Biomedical subjects

J Hansz

Publications and source records attributed to J Hansz.

At least 73 records · Page 4Linked to original sources
PubMed1981

[Granulocyte turnover in advanced Hodgkin's disease].

In 30 adult patients with III and IV Hodgkin's disease the studies of granulocytic turnover were performed. Bone marrow storage pool was measured by hydrocortisone test. Total blood granulocyte pool was judged by the estimation of muramidase activity and serum unsaturated vitamin B12 binding capacity. The epinephrine test was used for the marginated granulocyte pool determination. The circulating granulocyte pool was calculated from the count of granulocytes in the samples of venous blood. The tissue mobilization of granulocytes was measured by Senn's et al. method. After hydrocortisone application the releasing of the mature granulocytes from the bone-marrow was significantly lower in patients with Hodgkin's disease than in controls. The circulating and marginated pools of granulocytes in Hodgkin's disease did not differ from the normal persons. The tissue migration of granulocytes was decreased in patients with Hodgkin's disease. It is concluded that these abnormalities of granulocytic turnover in advanced Hodgkin's disease may be considered to be an additional cause of the defence mechanism in this disease.

Adult↗
PubMed1981

Stabilization of transcobalamins against heating on sephadex G-50.

The human serum stabilized on Sephadex G-50 did not show any changes in the distribution of radioactive vitamin B12 bound to transcobalamins during incubation at 56 degrees C (30 and 120 min.) and 80 degrees C (20 min.), whereas, in the non-stabilized serum, heating increased the vitamin 57CoB12 in transcobalamin I and III fraction and decreased or completely abolished the amount of radioactive vitamin B12 bound to transcobalamin II.

Blood Proteins↗
PubMed1979

[Lysine metabolism in acute leukemia].

The metabolism of 14C-lysine by leukaemic cells in acute myeloblastic, myelomonocytic, lymphoblastic and chronic myeloid leukaemia with blast crisis was studied. The investigations included lysine metabolism to CO2, lipids, organic acids and nucleotides and its incorporation into cellular proteins. The obtained results were compared with determinations carried out in granulocytes and lymphocytes of healthy subjects. Cells in acute leukaemias metabolized 14C-lysine in a similar range. In relation to normal cells the range of lysine metabolism to lipids in the leukaemic cells was significantly higher (p less than 0.01), while that of organic acids was significantly lower (p less than 0.05). The activity of 14C-lysine metabolism depended on the number of blast cells in the sample and the type of acute leukaemia. Neoplastic cells in blast crisis and in acute myeloblastic leukaemia incorporated more actively 14C-lysine into proteins than cells in acute myelomonocytic and acute lymphoblastic leukaemia (p less than 0.05). Similar differences in lysine metabolism were observed between myelomonocytes and blast cells from acute lymphoblastic leukaemia (p less than 0.05).

Adolescent↗
PubMed1979

[Lymphocyte acid phosphatase activity in lymphocytic leukemia studied in tissue culture with the use of diffusion chambers].

The reported investigations showed that lymphocytes in chronic lymphocytic leukaemia with low acid phosphatase activity had a rise of this enzyme level during culture in diffusion chamber. This rise is caused by increased number of lymphocytes with activity grades 1 degree and 2 degrees, and from the 6th day of culture also the number of lymphocytes with 3 degrees and 4 degrees activity score rose as well, while at the same time the proportion of cells without acid phosphatase activity fell. In the lymphocytes of healthy subjects a rise in acid phosphatase activity was observed as well under the same culture conditions.

Acid Phosphatase↗