The objectives of this descriptive study were to investigate anxiety and depressed mood of patients with burns associated with debridement and their preferences for and perceptions of control during the debridement procedure. Measurements began within 48 hours of hospital admission, continuing every 3 days over 2 weeks for subjects with small burn injuries (less than 30% of total body surface area). Data suggested the possibility of a mildly depressed mood for some subjects during the first week in the hospital and high levels of association between depressed mood and anxiety based on the large number of significant correlations (p < .05). Over time, the amount of control that patients preferred and the amount of choice they perceived during debridement increased. These findings about responses of patients with burns to debridement suggest that their emotional responses were well managed for the most part and support their involvement in the debridement procedure.

Adult↗

PubMedDate not supplied

Microsatellite instability in endometrioid endometrial carcinoma: correlation with clinically relevant pathologic variables.

This study of 218 patients with endometrioid endometrial carcinoma explores the relationship between microsatellite instability (MSI) as established by the BAT26 method and the common pathologic variables of prognostic and therapeutic significance. MSI was positively correlated with grade, associated endometrial atrophy, squamous metaplasia, isthmic involvement, depth of myoinvasion, vascular invasion-associated changes, extrauterine tumor spread, and extramyometrial angiolymphatic spread. There was no significant correlation with carcinoma developing in adenomyosis, mucinous metaplasia, tumor size, cornual involvement, cervical extension, uterine serosal involvement, and targeted lymphoid response. The positive correlations are discussed in terms of molecular genetics.

Adult↗

PubMedDate not supplied

Statistical analysis of pathologic risk factors for intramyometrial lymphvascular space involvement in myoinvasive endometrial carcinoma.

In a retrospective study using univariate analysis, we identified tumor type (nonendometrioid vs endometrioid), depth of myoinvasion (MI), mode of MI (infiltrative vs cohesive), and direct anatomic invasion of the cervical wall from the isthmus as significant positive risk factors for intramyometrial lymphvascular space involvement (LVSI). On multivariate analysis, tumor grade, depth of MI, and mode of MI retained their significance. We created a grid for the relative risks of LVSI with respect to these variables individually or in combination. We suggest that our indirect estimate of the risk of LVSI can help in assessing prognosis and determining the need for adjuvant therapy whenever LVSI is important in clinical decision making, but its pathologic diagnosis is uncertain.

Adult↗