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Biomedical subjects

J Handa

Publications and source records attributed to J Handa.

At least 253 records · Page 14Linked to original sources
PubMed1976

Association of brain tumor and intracranial aneurysms.

A case of association of meningioma and four intracranial arterial aneurysms including one giant aneurysm is reported, and the available literature reviewed. The operative mortality of patients with coexistence of brain tumor and cerebral aneurysm is very high (40%). When the aneurysms are multiple, eight out of ten patients expired after operation. Association of a giant aneurysm and brain tumor is exceedingly rare. The present case seems to be the fifth reported case.

Adult↗
PubMed1975

[Bone scintigraphy in neurosurgical practice (author's transl)].

Skeletal scintigraphy employing the new 99mTc-labelled compounds-99mTc-diphosphonate and 99mTc-polyphosphate-has proved to be a reliable technique for the detection of primary and metastatic tumors as well as non-neoplastic conditions of the skeletal system including the skull and spine. Recent experiences in 26 consecutive neurosurgical patients are reported. The bone scintigraphy seems to be most valuable in the clinical management of patients suspected of harboring metastatic deposit in the nervous system. In patients with malignancies elsewhere, the incidence of bone metastases is unexpectedly high, but the radiographic survey often fails to reveal the lesions in the initial stage. Bone scintigraphy, on the other hand, is highly reliable in detecting the bone metastases in its earliest stage, and the routine use of bone scintigraphy in such cases would be expected to help avoiding the unnecessary surgical intervention, or changing the plan of management, for example, from surgery to the systemic chemotherapy. Futhermore, bone scintigraphy seems to be useful in selecting the suitable site for biopsy, or in determining the targets for radiation treatment.

Bone Neoplasms↗
PubMed1975

Effect of phenoxybenzamine on experimental cerebral arterial spasm in cats.

The effect of topical and intravenous administration of phenoxybenzamine, an alpha adrenergic blocking agent, on experimental vasospasm was studied in cats. Topical application of phenoxybenzamine prevented the occurence of vasospasm without noticeable systemic alpha adrenergic blocking effect. Intravenous use, however, was ineffective in the dosage with which total systemic alpha adrenergic blockade was obtained. Effects of intravenous administration in much larger dosage seemed to be largely due to the non-specific action of phenoxybenzamine on vascular smooth muscle.

Administration, Topical↗
PubMed1975

Continuous measurement of intracranial pressure with SFT: clinical experiences.

In 29 consecutive patients, the epidural intracranial pressure (EDP) was continuously measured with a semiconductor strain film transducer, and with a telemetric monitoring system in two patients. Factors affecting the EDP during pre-, intra- and postoperative periods were analyzed and their significance in clinical practice stressed.

Anesthesia, General↗
PubMed1975

[Effect of phenoxybenzamine on the experimental cerebral vasospasm in cats (author's transl)].

Effects of topical and intravenous administration of phenoxybenzamine (PBZ) on the experimental vasospasm were studied in cats. Cerebral vasospasm was produced by a topical application of blood, prostaglandin (PG) E2 or PGF2alpha to be exposed basilar artery. Topical PBZ caused a significant dilatation of the basilar artery and the occurrence of vasospasm was completely prevented either with blood, PGE2 or PGF2alpha. Intravenous administration of PBZ in the dosage with which the pressor response to phenylephrine was completely blocked, or three times that dosage, failed to show any preventive effect on the vasospasm. From these experimental results, it seems that the antispasmogenic action of topically applied PBZ is due largely to the non-spacific vasodilator action of PBZ and not to its alpha adrenergic blocking action. It is also suggested that the role of alpha adrenergic mechanism in the genesis of vasospasm in this experimental design is not significant.

Animals↗