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Biomedical subjects

J Haller

Publications and source records attributed to J Haller.

203 records · Page 12Linked to original sources
PubMedDate not supplied

Comparison of five anxiolytic benzodiazepines on measures of psychomotor performance and sleep.

The behavioural toxicity of five anxiolytic benzodiazepines was examined in 28 volunteers who were studied in two groups of 14 subjects each. Each drug was taken nocte for 7 days, with a 4-week washout period between drugs. Assessments of psychomotor performance and sleep were made the morning following the first administration and the morning following the last administration. Comparisons of drug effect magnitudes using Cohen's d scores suggest that effects on psychological function should be considered as central to the selection and use of such compounds.

Adult↗
PubMedDate not supplied

A single ascending dose study of epigallocatechin gallate in healthy volunteers.

This randomized, double-blind, placebo-controlled study assessed the safety, tolerability and plasma kinetic behaviour of single oral doses of 94% pure crystalline bulk epigallocatechin gallate (EGCG) under fasting conditions in 60 healthy male volunteers. In each group of 10 subjects, eight received oral EGCG in single doses of 50 mg, 100 mg, 200 mg, 400 mg, 800 mg or 1600 mg, and two received placebo. Blood samples were taken at intervals until 26 h later. The area under the concentration-time curve from 0 h to infinity (AUC(0-infinity)), the maximum plasma concentration (Cmax) of EGCG, the time taken to reach the maximum concentration (Tmax), and the terminal elimination half-life (t1/2z) of EGCG were determined. Safety and tolerability were assessed. In each dosage group, the kinetic profile revealed rapid absorption with a one-peak plasma concentration versus time course, followed by a multiphasic decrease consisting of a distribution phase and an elimination phase. The mean AUC(0-infinity) of total EGCG varied between 442 and 10,368 ng.h/ml. The according mean Cmax values ranged from 130 to 3392 ng/ml and were observed after 1.3-2.2 h. The mean t1/2z values were seen between 1.9 and 4.6 h. Single oral doses of EGCG up to 1600 mg were safe and very well tolerated.

Absorption↗
PubMedDate not supplied

A device for applying static loads to prosthetic limbs of transtibial amputees during spiral CT examination.

This paper describes a device that allows the imaging of prosthetic legs under load conditions using spiral computerized tomography (CT). The device consists of a chair and a vertical footplate mounted on a 17.8 x 1.9 cm oak board that is 197 cm long. The load device can be easily positioned onto the CT bed. A subject sits in the chair and applies force by pushing the foot portion of the prosthesis against the footplate. The magnitude of the force is monitored by a digital force gauge coupled to the footplate. Because the load is borne by the hips and lower back of the subject against the chair, substantial forces can be generated and steadily maintained for the 20-45 s duration of the CT study. This device has been used successfully with 19 transtibial amputees, allowing the acquisition of spiral CT studies with half and full body weight loads.

Amputation, Surgical↗