The Atlantis platform: a new design and further developments of Buresova's on-demand platform for the water maze.
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Biomedical subjects
Publications and source records attributed to J Hall.
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This qualitative study sought to identify the strategies used by hospital based midwives in assisting women to manage pain in labour, as well as the support they offer in all aspects of the birth process. Data were collected via participant observation of five birthing mothers and their midwives, and pre and post birth interviews. Analysis was by means of the software package QSR NUD.IST (Non numerical, Unstructured, Data, Indexing, Search and Theorizing) Version 3. Analysis of observation of labour and pre and post birth interviews revealed that all women wanted a birth with minimal intervention, however safety was an overriding consideration. During labour women relied on the midwife to oversee and direct care, and trust in care by a midwife was established as a result of prior experience, or during antenatal care. Factors inhibiting full partnership between women and midwives, and also the use of alternative pain strategies, included staffing levels, lack of emphasis on evidence based care and environmental constraints such as the room set up.
Pain is complex and difficult to define; Managing pain is challenging for all members of the interprofessional team; Untreated pain is harmful to the patient; Pain is a subjective and unique experience for the individual, which we, as health professionals, should not judge; Staff do not know best--listen to what the patient is telling you; Base your evaluation of pain upon a thorough clinical assessment and an evaluation of treatment/care. Use pain measurement tools to aid this process; Effective communication with patients is essential for effective pain management.
Epidural analgesia can provide excellent pain relief for patients. Nurses must have a knowledge of its application and possible adverse effects so as to provide high-quality care. Epidural analgesia may be delivered as a continuous infusion or a bolus injection. Opioids and local anaesthetics are the main drugs used. Close monitoring of the patient is vital to detect any adverse effects.
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Just over 20 years ago, an attempt was made to determine to what extent schools of nursing provide recruitment information for potential candidates to nursing. The recruitment literature and application forms of 40 general hospitals and 20 psychiatric hospitals were analysed. A follow-up investigation was carried out 10 years later, in 1980, which sought to establish to what extent the recruitment process, in terms of information-provision and requisition, for potential nursing candidates had changed. The study was also expanded to include an analysis of the recruitment literature and application forms of 20 mental handicap hospitals. The conclusions from the initial study and the 1980 follow-up, together with a second follow-up study completed in 1990, are outlined here and in Part 2 next month, looking at the extent to which schools of nursing have changed their initial recruitment processes over the past 20 years.
In 1970, a study was carried out to assess the type of information provided by schools of nursing to recruit prospective candidates to the profession. A follow-up study in 1980 showed that some response had been made to suggestions about particular types of information that potential recruits required (see Part 1, April 29). This week, in Part 2, the changes that have taken place in information exchange between 1980 and 1990 are assessed.
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Two model enzymes, heparinase and bilirubin oxidase, were immobilized via cyanogen bromide, tresyl chloride, epoxide, or carbodiimidazole activated natural and synthetic matrices. The supports released enzymes for 4-20 hr in vitro at 37 degrees C. The most stable linkage was formed by tresyl chloride and oxirane activated supports. No immune response was detected 11 or 21 days after single i.v. injection to New Zealand white rabbits. Acute exposure to the enzyme produced a weak positive response.
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In 39 patients with advanced colorectal cancer and no previous chemotherapy, treatment with chlorozotocin was associated with a 5% objective response rate and a median survival of 19 weeks. All of the responses occurred in patients with rectal tumors. Mild gastrointestinal symptoms affected 64% of the patients after treatment, but bone marrow suppression was not evident. Chlorozotocin is not effective against colorectal cancer when used as a single agent given as an iv bolus at doses of 120 mg/m2 (30 patients) and 150 mg/m2 (nine patients). However, further studies using a higher dose might be worthwhile.