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J Halberg

Publications and source records attributed to J Halberg.

At least 19 recordsLinked to original sources
PubMed1987

Chronobiologic monitoring and analysis for anesthesiologists: another look at a chronoanesthetic index.

A circadian rhythm in anesthetic index is quantified by the single cosinor method in data published earlier. Although the double circadian amplitude, a measure of the extent of predictable change, is only 14%, the assumption of no rhythm (zero amplitude) is rejected at the 1% level of statistical significance. It seems likely that, in the absence of noise, the amplitude of the rhythmic change in the response to the anesthetic will be larger. The broader importance of chronobiology for anesthesiologists is also indicated. Hardware and software for the monitoring of a patient's vital signs before, during, and after surgery provide refined dynamic endpoints from the analysis of data series and lead to time-specified reference values that improve even the interpretation of time-specified single values.

Anesthetics↗
PubMed1981

Changes with age characterize circadian rhythm in telemetered core temperature of stroke-prone rats.

In a stroke-prone (SP) strain of laboratory rats, aging is associated with quantifiable changes of the circadian rhythm in body core temperature: (1) its timing becomes less tight, as revealed by a larger standard error of the acrophase (the peak in the 24-hour cosine function best approximating all data) and (2) the acrophase in old SPs occurs earlier than in young ones--quite apart from (3) a decrease in circadian amplitude reported earlier. These results gain particularly in interest in the context of the recent finding that a large (approximately 90 degrees) acrophase-advance is associated with bilateral lesions of the suprachiasmatic nuclei in inbred (non-SP) Fischer rats. These observations may be of interest to those developing models of aging functions in disorders with blood pressure elevation.

Aging↗
PubMed1981

Familial and individualized longitudinal autorhythmometry for 5 to 12 years and human age effects.

Statistically significant and biologically interesting changes (no decrease and even an increase) with age may characterize peak expiratory flow. This variable and others were investigated in the same persons by dense measurements for several years. A possible health benefit from the monitoring of personal health thus becomes apparent. The relative prominence of changes in body core temperature and 2-min estimation with circadian rhythms, as compared to those with aging is of basic interest. The population-based presumption that aging necessarily involves an increase in overall-systolic and diastolic blood pressure is here aligned with an unusually well documented exception to this view.

Adolescent↗
PubMed1980

Meal timing alters circadian rhythm of skin surface temperature in non-human primates.

Circadian rhythms of skin surface temperature were demonstrated in a group of African green vervets. Alteration of the timing of a single daily meal of fixed caloric content resulted in a shift of the skin surface temperature acrophase in 7 of the 8 series. The timing of the individual temperature acrophases in relation to the light-dark cycle and the extent of acrophase shift in response to alteration of meal timing showed considerable variation between the individual animals studied.

Animals↗
PubMed1979

Schedule shifts, life quality and quantity--modeled by murine blood pressure elevation and arthropod life span.

During the span from 50 to 100 days and beyond, the male stroke-prone Okamoto rat develops systolic blood pressure measures in excess of 200 mm Hg. In the course of developing such a marked elevation in systolic blood pressure mean, this intermittently handled male Okamoto rat exhibits a statistically significant circadian rhythm with large amplitude. This amplitude may represent, at least in part, a response to intermittent handling; it is several times larger than the amplitude for spontaneously mesor-hypertensive (but not stroke-prone) female animals of the same age.

Aging↗
PubMedDate not supplied

Chronobiology: a frontier in biology and medicine.

On the occasion of Franz Halberg's 70th birthday, some of his many achievements are reviewed. We provide a historical background to the development of chronobiology; offer insight into the current state of this new science; and sketch the promise of this discipline for health care and cure. As a tribute to Franz Halberg, in an era of fast-growing technology, an attempt is made to describe his perspective of tomorrow's medicine and biology. The many students he trained throughout his productive career face the challenge of deserving the trust he placed in them and of further implementing his vision. A leader in social pediatrics put it aptly: it will take several generations of researchers to study and master his life's work.

Animals↗
PubMedDate not supplied

Further steps toward a neonatal chronocardiology.

The study of 53 series of blood pressures at half-hour intervals from clinically healthy full-term newborns during the first days of life reveals various classifiers correlating with a history of high blood pressure: the circadian amplitude of diastolic blood pressure, the 50% range of systolic blood pressure and the standard deviation of heart rate.

Cardiovascular Diseases↗
PubMedDate not supplied

Catfish anyone?

Explore the source record for details and available documents.

Animals↗
PubMedDate not supplied

Comparative effects of meal timing on circadian rhythms of plasma insulin and skin surface temperature in non-human primates.

Circadian rhythms of plasma immunoreactive insulin and skin surface temperature were demonstrated in a group of African green vervets. Alteration in the timing of a single daily meal of fixed calorie content resulted in an acrophase shift of plasma immunoreactive insulin for the group of animals and in an acrophase shift of skin surface temperature in 7 or the 8 animals studied. The acrophase shift of skin surface temperature was considerably less then the shift of acrophase of plasma immunoreactive insulin, which closely approximated the shift in meal timing. The results of this study are compared with results of similar studies in human beings.

Animals↗