Search PubMed⌕ Search

Biomedical subjects

J H Thomas

Publications and source records attributed to J H Thomas.

At least 163 records · Page 9Linked to original sources
PubMed1979

A comparison of various parameters of social grade: a study of a Sydney population.

A comparison has been made between different methods of classifying a Sydney population of 118 persons into social grades. A positive correlation was found between address and occupation, education and occupation, occupation and father's occupation, address and education, address and father's occupation, and education and father's occupation, all correlations being significant at or below the P=0.004 level of statistical significance.

Australia↗
PubMed1979

Insulin degradation. XXV. Glutathione-insulin transhydrogenase activity of rat liver and kidney during the development of streptozotocin-diabetes.

The activity of glutathione-insulin transhydrogenase (glutathione:protein-disulfide oxidoreductase, EC 1.8.4.2) in the liver and kidneys of rats during the development of streptozotocin-induced diabetes has been studied. Following a single injection of streptozotocin, the transhydrogenase activity fell rapidly for 7-8 days and then gradually with time in both organs. In contrast to the control rats where approximately 25% of the enzyme is in a 'latent' state, nearly all the transhydrogenase activity in the diabetic liver appears to be in the free or functional form. The results are consistent with the hypothesis that both hepatic and renal glutathione-insulin transhydrogenase activity are under feedback control by circulating insulin. The possibility is discussed that the latent state may represent a storage form of the enzyme, which in insulin-insufficiency states is mobilized to the free or functional form for cell function.

Animals↗
PubMed1979

Influence of preformed antibody on experimental Streptococcus sanguis endocarditis.

The influence of preformed, anti-whole organism antibody on the development of Streptococcus sanguis endocarditis was examined in both in vivo and in vitro systems. Antibody prevented, rather than potentiated, endocarditis in rabbits. The infectious dose in 30 control animals was 10(6.5) +/- 0.33 (mean +/- standard deviation); this increased to 10(7.71 +/- 0.05 in 36 immunized animals (P less than 0.01). No differences in bacterial clearance mechanisms were apparent between groups. Antibody also prevented the adherence of S. sanguis to the constituents of nonbacterial thrombotic endocarditis (fibrin and platelets) in vitro. When preincubated in high-titer antisera, adherence of S. sanguis was reduced compared with controls (adherence ratio mean +/- standard error of the mean, X 10(4): 174 +/- 5 versus 427 +/- 10, P less than 0.001). Preadsorption of immune sera with intact S. sanguis restored adherence to normal values, whereas preadsorption with dextran was partially effective. These studies demonstrate that preformed antibody had a protective role in vivo and suggest that a possible mechanism is blockade of adherence, a crucial early step in the pathogenesis of endocarditis.

Animals↗
PubMed1979

Assessment of chemical tests for faecal occult bleeding and correlation of results with presence or absence of anaemia.

Stools from 88 consecutive patients in acute geriatric wards were tested for occult blood by four common commercial methods. The Peroheme and Haemostix tests were found too sensitive for general use, the Okokit and Haemoccult tests being preferable. Positive tests were correlated with anaemia in 27 patients, iron deficiency in 26, iron deficiency anaemia in 15, non-anaemia in 52, non-iron deficiency in 43 and with absence of both in 27. Such testing has been considered unnecessary in anaemic patients without gastrointestinal symptoms.

Aged↗
PubMed1979

Scintiscans in the evaluation of patients with malignant melanomas.

In an attempt to define the role of scintiscanning in patients with a malignant melanoma, 349 liver, bone and brain scans in 136 patients have been reviewed. No patient with clinical Stage I or II disease was found to have occult metastases detected by scintiscans. All patients with proved positive scans demonstrated clinical symptoms consistent with the results of scintiscanning. Scintiscans in patients with a malignant melanoma are most effectively used to evaluate the symptomatic patient with Stage I or II disease and all patients with Stage III disease. Histologic verification of positive scans in patients with Stage I and II disease avoids unwarranted therapeutic decisions. There is, however, practical value in being able to predict accurately the absence of metastatic involvement. In only two of 249 examinations did the scans fail to detect metastases. A normal scan is a strong indicator of the absence of metastatic disease.

Adolescent↗
PubMed1979

Bilateral pneumothoraces secondary to colonic endoscopy.

Fiberoptic colonoscopy has significantly altered the managment of patients with colonic diseases. Complications of colonoscopy are not common, but most often include hemorrhage and perforation. This report describes an unusual and interesting case of colonic perforation related to fiberoptic colonoscopy in which the perforation presented as bilateral pneumothoraces.

Colon↗
PubMed1977

Tricuspid stenosis secondary to metastatic melanoma.

Cardiac metastases from malignant melanoma are frequent, usually asymptomatic and occur terminally. When responsible for symptoms, close evaluation of the patient is imperative for correct diagnosis and subsequent therapy. Surgical intervention where indicated in combination with chemotherapy and judicious use of irradiation constitutes optimal therapy.

Adult↗
PubMed1977

Endodermal sinus tumor of the ovary and alpha fetoprotein: a case report.

Yolk sac tumors of the ovary are associated with elevations in serum levels of alpha fetoprotein (AFP). Thus, an antigenic marker is provided for evaluating therapeutic results in selected patients. A patient with a pure endodermal sinus tumor of the ovary is presented who underwent serial determinations of AFP. The effectiveness and limitations of serial AFP levels as demonstrated by this case are discussed in addition to the surgical and chemotherapeutic management of patients with yolk sac tumor of the ovary.

Adult↗
PubMed1977

B1-3,5-diiodotyrosine insulin: a valid tracer for insulin.

Insulin, specifically substituted at the PheB1 position with 3,5-diiodotyrosine, has been tested in several biological and immunological systems. Immunoreactivity was assessed using antisera specific for different parts of the insulin molecule. Biological activity in vitro was estimated on isolated rat fat cells. In vivo bioactivity (hypoglycaemia) and metabolism (metabolic and urinary clearance rates, half-life, apparent distribution space) were measured by infusion of the material into greyhounds. The results indicated that this B1-labelled insulin preparation was biologically fully active and, unlike randomly labelled preparations of iodoinsulin, was metabolised with kinetics indistinguishable from those of the unlabelled hormone. We suggest that this material is a valid tracer for insulin, fulfilling the criteria of high specific activity and biological identity to the native hormone.

Adipose Tissue↗