Search PubMedSearch

Biomedical subjects

J H Scharf

Publications and source records attributed to J H Scharf.

12 recordsLinked to original sources

[Turning points in cytology].

There is given a concise and woodcut-like survey over the history of cytology with was born by the pioneering of Hooke, Grew, Malpighi, and van Leeuwenhoek at the end of XVIIth century and three crises of this science. The first crisis of cytology resulted from barren discussions of the so-called preformation hypothesis and the monadism of Leibniz. These philosophical speculations caused a melting away of the concrete facts during the XVIIth century. After the rebuilding of cytology by Meyen and Brown during the XIXth century's early thirties and the propounding of the early cell-theory by Schleiden and Schwann, the second crisis was provoked since Schleiden and Schwann, clearer than Meyen, kept the hypothesis of equivocal or spontaneous generation that was alive since Aristotéles. This 2nd crisis showed a belated sequel in the middle of XXth century brought about by sloppy investigations of Lepesinskaja. The third crisis concerns the question whether there is or whether there is not existent a membran enveloping every animal cell. Whereas Schwann himself presupposed the cell membran as an integral part of each cell, Max Schultze negates its existence. After the creation of the membran theory of synapse by Sherrington, the neuron theory by Ramón y Cajal, and the membran theory of narcosis by Meyer and Overton, the negation of the cell membran was being combined successively with the neovitalistic hypothesis of neuronal networks of Bethe and others. This spectre could really wiped out not before the modern histochemistry and electron microscopy were established in the fifties of our century.

Animals

[The dialectic of glottogenesis--a contribution to the foundation of biolinguistics].

Some analogies were demonstrated between the spontaneous acquisition of phonemes, especially gutturals and clicks, and their also spontaneous extinction during the early babble phase of infants on the one hand and the appearance and involution of some blastemata throughout the human ontogenesis on the other hand. Also analogues seem to be the producing of the so-called instinctives as mam(m)a and papa by somewhat older babies which are able to pass over from the babbling into permanent words of the adults' speech in which they persist if used without shifting of sounds since they are produced de novo generation by generation, but they are subordinate to shifting and possible extinction if used in the form of derivatives in the standard language, and some phenomena of the phylogenesis as the survival of less differentiated species contrary to the relatively quick extinction of the highly specialized ones. Thus the glottogenesis is a dialectic process consisting of interaction by formation, differentiation, and involution.

Humans

[Time from the viewpoint of Cantor's and post-Cantorian set theory--a contribution to the founding of chronobiology].

There is given a survey of the evolution of the idea of time in the mankind's thinking from the beginning down to the term's application in sciences and in the philosophy. As one can point out from some languages, living as well as extincted ones, the words for time are derived etymologically from several roots or stems, respectively, which mostly represent different meanings. But by increasing abstraction in all civilized languages, the process of stripping the different words of their concrete accompaniments led up to a narrow of the diverse meanings which converged towards the common understanding of time in modern sciences. Nevertheless time is no unequivocal term as one can show by linguistic and mathematical analysis. Especially by means of the theory of differential equations and the set theory, the chimerical nature of time is demonstrable, so that time is only an abstraction of abstractions.

Biological Evolution

[Reflections on the problem of "discreteness" and "steady state" in living processes].

A survey is given over the different meaning of the dialectic pair of terms continuity and discontinuity in philosophy contrasting with sciences. In mathematics, the term continuum is defined by Cantor in set theory as the innumerable multitude of the real numbers especially in the interval [0, 1]. The discontinuum means in Cantor's definition the rational fractions in [0, 1] which in triadic development do not contain the figure 1 [written I). In a more general sense, continuum is used in the mechanics of continuous fluids and gases in physics as well as in physiology. Here, the use of this term neglects the reality of intermolecular spaces intentionally. To employ in the life sciences, the pair of terms steady state and discreteness is clearer. Processes of life mostly are steady in the sense of balanced proceedings but numbers of individuals, cells, molecules, sexes etc, are discrete only. For example, the difference or the dimorphism between males and females is a distinct one between two different conditions but cannot be projected on "discontinuity". Discreteness as a term comprehends Boole an variables as are male-female, living-dead, as well as crowds of measure points.

Animals

[Goethe's morphology definition and the problem of relationship of the Cro-magnons to the primitive Germans (Carl Gegenbaur)].

The problem of the Teutons' origin has been considered to be open up to this day though some scientists have worked on this field since 1912. Anthropologists and linguists as BRAUN, FEIST, GUNTERT, KOPPELMANN, PAUDLER and V.D. VELDEN produced many evidences in favour of the hypothesis the Teutons to be a mixture of the Old European Cro-Magnons speaking an archaic ural-altaic idiom with the Indo-Europeans immigrating into Europe from Asia. The Kelts may have a similar origin but they might include the Berbers of ancient Iberia as a third component. The hypothesis mentioned above was able to be ignored as far as an archaic language of the postulated type was unknown in the extremely western Euro-Saharanian territory. By means of a aerohydrodynamic model a hint was received to the probable existence of such a language in western Atlas or in one of the Mauretanian oases. This is not the case. But an archaic not-Berberized language preserved until the Spanish Conquest is found on the central isles of the Canary Islands. This language is handed down by some Spanish, Portuguese, and French chroniclers but mostly by the Italian engineer TORRIANI. His autograph found out and published by WOLFEL (1940) contains two poems (endechas), some sentences, and many separate words. Other clauses and single words are held in the manuscripts of the other writers. The oldest layer of Canary language (i.e. the Altaic stratum) passed for unintelligible until the summer of 1977. The earliest colonization of the Canary Islands by Crô-Magnons is doubtless on the strength of many anthropological examinations. The analysis of the two endechas and of 12 clauses tolerably handed down shows an Altaic language of an early type which still consists of words and formatives surviving only in one or two of the today's Altaic daughter-languages as Turkish, Mongolian, and Tunguso-Manchu, only seldom in all of them. The conicidence of surviving both of Crô-Magnon-typical men and of the archaic Altaic language on the Canary Islands as a reservation of megalithic civilization up to the Middle Ages (XVIth century) approves the hypothesis mentioned above.

Anthropology, Cultural

[Dialectics of time].

The modern chronobiology searches not only purely cyclic processes of life but also such ones in which a non-cyclic trend is superposed by a strongly periodic course. In strong periodicity, flight of time in itself shows a cyclic structure, but in contrary sense, aperiodical, strongly damped processes have a linear structure of tern part of the 20th century's sciences, but its philosophical model representation is able to be retraced until the zervanitic speculations of the Olden Iran. Since the time of the Zervanite, some antinomies in philosophic and physical chronology are found. The present paper mentions the antinomies of PLATON, ARISTOELES, NEWTON, MILNE and the modern palebiology.

Biology

[Growth].

Explore the source record for details and available documents.

Animals

[(An algorithm for determining values of parameters of the Gompertz growth function)].

In the literature some attempts were made to analyse and to construct models for biological growth processes and to describe the quantitative aspects of a growth characteristic's changes in time using the Gompertz' function y=aexp(-exp(b--ct)). In this paper differential equations are derived having the Gompertz' function as solution. The goodness of fit after adjusting a chosen analytical expression to the courses of measured values is able to give hints at the reliability of that expression as a true model. This possibility of verification was hardly practiced in past because of lacking in proper numerical procedures for performing the nonlinear regression. An ALGOL program for iterative adjusting the parameters of the GOMPERTZ' function (with or without a constant term) to measured values is given in an appendix of the present paper. Starting values for the nonlinear parameters b and c will be evaluated by Internal Least Squares using one of the derived differential equations. For this algorithm an ALGOL program is given in the appendix too. The growth of human embryo serves as an example to demonstrate the numerical procedures and related programs for evaluating the starting values of the parameters and for their iterative improvement until reaching a minimum for the remainding variance between calculated and measured courses.

Computers