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Biomedical subjects

J H Rommes

Publications and source records attributed to J H Rommes.

24 records · Page 2Linked to original sources
PubMed1987

Biocompatibility of hemodialysis using cuprophane membranes.

In a controlled study of the influence of hemodialysis on hemodynamics, complement system, leucocyte- and thrombocyte concentration was studied in two groups of five non-uremic dogs each. During the initial 30 min of dialysis with the commonly used cuprophane membrane, a transient but significant decrease of the mean aortic pressure and cardiac output occurred while simultaneously heart rate and systemic vascular resistance decreased. Thrombocyte concentration decreased significantly during the initial 60 min of dialysis due to sequestration in the dialyzer. Transient leucopenia due to pulmonary leucostasis occurred without decrease of the arterial oxygen tension. The simultaneous occurrence and transient character of the hemodynamic changes, leucopenia and thrombocytopenia suggest a relationship between these phenomena. These results indicate that the biocompatibility of cuprophane dialysis membranes is of importance not only with regard to changes in the leucocyte- and thrombocyte-count but also with regard to hemodynamic changes.

Animals↗
PubMed1986

Biocompatibility of haemoperfusion.

To evaluate the influence of haemoperfusion on haemodynamics, complement system, leucocyte and thrombocyte concentration, a controlled study was performed in three groups of five dogs each. During the first 30 min of haemoperfusion with columns containing cellulose-coated activated charcoal, a significant decrease of mean aortic pressure, cardiac output and stroke volume was observed, while heart rate and total systemic resistance decreased. A comparable phenomenon, although to a much lesser extent, was observed during perfusion using columns containing polystyrene resin. Perfusion with columns containing cellulose-coated activated charcoal caused a significant decrease in total haemolytic complement, indicating activation of the complement system. A significant decrease in the leucocyte and thrombocyte concentration due to sequestration of granulocytes and thrombocytes in the columns was observed during the first 30 min of perfusion in both groups. Pulmonary leucostasis, without decrease of arterial oxygen tension, occurred during perfusion with columns containing cellulose-coated activated charcoal. Both the simultaneous occurrence and the transient character of the haemodynamic changes, complement activation and sequestration of granulocytes and thrombocytes in the perfusion column suggest a relationship between these various changes. The results stress the importance of close monitoring of the haemodynamic parameters of the intoxicated patient, particularly during the early phase of haemoperfusion.

Animals↗
PubMed1983

The influence of haemoperfusion on white cells, immunoglobulin concentrations and the complement system in the treatment of intoxications.

The influence of haemoperfusion on some immunological parameters was investigated in a pilot study involving two groups of three patients each. In columns containing cellulose-coated activated charcoal or polystyrene resin a temporary reduction of the total white cell number, particularly involving the segmented and band neutrophils, was demonstrated. Cellulose-coated activated charcoal and, to a lesser extent, polystyrene resin induced activation of the complement system using C3d as a parameter. An appreciable decrease of immunoglobulin or complement levels could not be demonstrated in either column.

Adult↗