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Biomedical subjects

J H Oh

Publications and source records attributed to J H Oh.

At least 73 records · Page 4Linked to original sources
PubMed1977

Prognostic use of preoperative and immediate postoperative carcinoembryonic antigen determinations in colonic cancer.

Preoperative and postoperative carcinoembryonic antigen (CEA) concentrations are useful in predicting the likelihood of recurrence in patients undergoing curative operations for cancer of the colon. The incidence of recurrence was studied in three groups of patients followed for 6 to 18 months after such an operation: 36 patients (group 1) had preoperative and postoperative plasma CEA concentrations less than 2.5 ng/ml; 11 patients (group 2) had a preoperative CEA value above but a postoperative value below 2.5 ng/ml; and 11 patients (group 3) had preoperative and postoperative concentrations greater than 2.5 ng/ml. Cumulative rates of recurrence at 6, 12 and 18 months after operation were as follows: 0, 3 and 17% in group 1; 0, 9 and 21% in group 2; and 27, 79 and 79% in group 3. Statistically there was no difference in the recurrence rate between groups 1 and 2, but the rate was significantly lower in group 2 compared with group 3. The data show that patients in whom the immediate postoperative CEA concentration returns to normal have a much lower incidence of recurrent cancer of the colon than patients whose CEA concentration remains elevated.

Carcinoembryonic Antigen↗
PubMed1977

Lack of association between breast cancer and HLA (A and B) specificities: importance of age-matched controls.

HLA (A and B) antigen frequencies in 100 women with breast cancer were compared with those in 2 groups of cancer-free control women: the first control group (263 subjects) were age-unmatched, and the second (75 subjects) age-matched. The mean age and standard deviation were 56 +/- 13 years for the patient group, 25 +/- 3 years for the first control group, and 53 +/- 10 years for the second. It was first noted that HLA-B13 was significantly less prevalent among the patients with breast cancer when compared to the first control group (1% versus 7.2%, p = 0.025). However, when the patient group was compared to the second control group, no difference was found in the frequency of HLA-B13 (1% versus 1.3%, p = 0.80) or any other antigens. Age can be an important variable in a study of correlation between HLA and disease.

Adult↗
PubMed1975

Diseases associated with specific HL-A antigens.

Significantly increased prevalences of particular HL-A antigens have been reported for many human diseases. The correlation is particularly striking in ankylosing spondylitis, Reiter's syndrome, psoriasis and some immunopathic disorders, so that HL-A typing may be of great value in diagnosis. The possible mechanisms whereby these associations may occur suggest the cause of certain disorders, and further investiatation will likely help in the understanding of the pathogenesis of many diseases.

Arthritis↗
PubMedDate not supplied

Association between HLA-BW38 and peripheral psoriatic arthritis.

The frequency distribution of HLA antigens was studied in a group of psoriatic patients with and without arthritis. HLA-BW38 was found significantly increased in the group with peripheral psoriatic arthritis. There were no differences in the clinical features of the arthritis in the BW38 positive (+) and BW38 negative (-) individuals. It is suggested that BW38 is a genetic marker and/or an indicator of peripheral joint involvement in psoriatic patients.

Adult↗
PubMedDate not supplied

Presacral epidermoid cyst: imaging findings with histopathologic correlation.

BACKGROUND: The aim of this study was to determine the imaging characteristics of presacral epidermoid cysts and correlate the imaging findings with the histopathologic findings. METHODS: We retrospectively reviewed sonographic, computed tomographic, and magnetic resonance examinations in four consecutive patients with a pathologically proven presacral epidermoid cyst. Imaging findings of the presacral epidermoid cyst were correlated with the histopathologic findings. RESULTS: In all four patients, sonography showed a presacral mass with a heterogeneous low echogenicity, and computed tomography showed a discrete well-defined hypodense presacral mass with a thin wall. In the three patients who underwent magnetic resonance imaging, the mass showed a heterogeneous low signal intensity on the T1-weighted image and a high signal intensity with multiple small foci of low signal intensity in the nondependent portion of the mass on the T2-weighted image. These imaging findings correlated well with the pathologic results. Aggregates of keratinous material contributed to these imaging findings. CONCLUSION: In the diagnosis of the presacral epidermoid cyst, sonographic and magnetic resonance imaging findings may be helpful.

Adult↗
PubMedDate not supplied

Acetic acid as a sclerosing agent for renal cysts: comparison with ethanol in follow-up results.

PURPOSE: To compare follow-up results of sclerotherapy for renal cyst using 50% acetic acid with those using 99% ethanol as sclerosing agents. METHODS: Eighty-one patients underwent sclerotherapy and 58 patients, 23 males, 35 females, aged 6-76 years, having a total of 60 cysts, were included in this study; the others were lost to follow-up. The renal cysts were diagnosed by sonography, computed tomography (CT), or magnetic resonance imaging (MRI). Sclerotherapy was performed using 50% acetic acid for 32 cysts in 31 patients and 99% ethanol for 28 cysts in 27 patients. Under fluoroscopic guidance, cystic fluid was aspirated as completely as possible. After instillation of a sclerosing agent corresponding to 11.7%-25% (4-100 ml) of the aspirated volume, the patient changed position for 20 min and then the agent was removed. Patients were followed up by sonography for a period of 1-49 months. The volume of the renal cyst after sclerotherapy was compared with that of the renal cyst calculated before sclerotherapy. Medical records were reviewed to analyze complications. RESULTS: The mean volume after sclerotherapy of the 17 cysts followed for 3-4 months in the acetic acid group was 5.1% of the initial volume, and for the 14 cysts in the ethanol group it was 10.2%. Complete regression during follow-up was shown in 21 cysts (66%) in the acetic acid group; the mean volume of these cysts before the procedure was 245 ml. The mean volume of the nine (32%) completely regressed cysts in the ethanol group was 184 ml. Mild flank pain, which occurred in three patients in each group, was the only complication and resolved the next day. CONCLUSION: Acetic acid was an effective and safe sclerosing agent for renal cysts, tending to induce faster and more complete regression than ethanol.

Acetic Acid↗
PubMedDate not supplied

Bone bruises: MR characteristics and histological correlation in the young pig.

PURPOSE: To correlate magnetic resonance (MR) signal characteristics of bone bruises with histological findings. MATERIALS AND METHODS: In 14 tibiae of young pigs, bone bruises were created in the proximal tibial metaphysis. The signal intensity seen on the MR images were correlated with histological findings. The following findings were evaluated: (a) changes of signal intensity on the tibiae; (b) changes of histology on the tibiae; and (c) changes of (a) and (b) on follow-up examinations. RESULTS: We observed three types of injuries on T1-weighted images: focal or diffuse low signal, normal signal and linear low signal intensities. Severe hemorrhagic areas showed low signal intensities on all sequences of MR imaging. Fast spin-echo (FSE) T2-weighted images showed a more distinct low signal intensity than T1-weighted images. FSE short tau inversion recovery (STIR) and FSE fat saturated (FSE-FS) T2-weighted images showed similar signal intensities with FSE T2-weighted images. FS T1-weighted enhanced images showed low signal intensities with variable enhancements. Upon histological examination, hemorrhages and edemas were prominent at the subcortical areas of the contusion sites. The areas of dense, low signal intensities in all imaging sequences showed signs of severe hemorrhage. The areas of diffuse low signal and enhanced areas showed mixed areas of hemorrhages and edemas. Follow-up MR imaging showed evolution of the processes of hemorrhages and edemas with fatty marrow changes. CONCLUSIONS: MR imaging can depict changes in the bone marrow resulting from direct injury to the bone. MR imaging is a useful tool for evaluating the evolution of bone bruises.

Animals↗
PubMedDate not supplied

Isolation of leukocyte-free platelets from standard platelet concentrates by centrifugation.

We evaluated centrifugation techniques to isolate leukocyte-free platelets from standard platelet concentrates. Among various settings of centrifugation force and time, we found the setting at 300 X g for 10 minutes or 370 X g for 5 minutes to be efficient and reproducible for recovering sufficient quantities of platelets free of leukocytes.

Cell Separation↗