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Biomedical subjects

J H Moore

Publications and source records attributed to J H Moore.

At least 91 records · Page 5Linked to original sources
PubMed1973

Food particles as a site for biohydrogenation of unsaturated fatty acids in the rumen.

On incubation of linoleic acid with strained rumen contents from sheep, it was observed that conversion of linoleic acid into C(18:1)trans-11 monoenoic acid and subsequently into stearic acid was largely associated with the food-particle fraction. The bacteria, protozoa and cell-free supernatant together contributed less than 30% to the overall change in the added C(18:2) fatty acid.

Animals↗
PubMed1972

Mellein and 4-hydroxymellein production by Aspergillus ochraceus Wilhelm.

Mellein and 4-hydroxymellein are isocoumarin compounds produced by Aspergillus ochraceus Wilhelm. They are structurally similar to the dihydroisocoumarin moiety of ochratoxin A, a toxic metabolite of the same fungus, and they possibly have similar biological properties. Production of mellein and 4-hydroxymellein on synthetic media and natural solid substrates was determined. Several carbon and nitrogen sources supported production of these metabolites in stationary culture. Additional zinc and molybdenum increased production of both metabolites in stationary culture, but were not required for maximum production in shaken culture. Mellein and 4-hydroxymellein were produced on yellow corn, but neither was produced on wheat, peanuts, or soybeans.

Analysis of Variance↗
PubMed1972

Tremorgenic toxin from Penicillium veruculosum.

A new mycotoxin that produces severe tremors and acute toxicity when administered orally or intraperitoneally (ip) to mice and 1-day-old cockerels was obtained from a strain of Penicillium verruculosum Peyronel isolated from peanuts. The ip 50% lethal dose (LD(50)) of this tremorgen was 2.4 mg/kg in mice and 15.2 mg/kg in chickens. Orally administered LD(50) values for the toxin were 126.7 mg/kg in mice and 365.5 mg/kg in chickens. The trivial name "verruculogen" is proposed for this tremorgenic mycotoxin. Physical and chemical characteristics of the mycotoxin are described.

Administration, Oral↗