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Biomedical subjects

J H Mateos

Publications and source records attributed to J H Mateos.

17 recordsLinked to original sources

[Levodopa].

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Dihydroxyphenylalanine

Cardiac arrhythmias in experimental subarachnoid hemorrhage.

Experimental subarachnoid hemorrhage (SAH) in dogs was produced by introducing blood into the subarachnoid space through a catheter connected to an artery of the animal. The intact animals and those with preserved vagi and heart sympathetic innervation, developed arrhythmias with short latencies which correlated with the sudden increase in the intracranial pressure. The animals with sections of both vagi and heart sympathetic innervation, but with an intact spinal cord, developed arrhythmias that were delayed and did not correlate with the changes in intracranial pressure. These arrhythmias were preceded by changes in the QT interval, T wave and ST segment. It was concluded that the arrhythmias could be produced either by direct autonomic discharges to the heart or by increased circulating and tissue catecholamines. The clinical implications of these findings are discussed.

Animals

[Inflammatory reaction in neurocysticercosis in experimental studies in rabbits].

In order to know if dexamethasone is a satisfactory protector to the inflammatory effect of cysticercosis in the central nervous system and if the rabbit is an useful animal for this experimentation twenty five rabbits were infected in the cisterna magna some with an emulsions of scolex and others with the fluid of the vesicle. The animals were sacrificed after two weeks and the brains were studied by the pathologist. The results indicate that dexamethasone is useful as a protector of the rabbit brain in cases of cysticercosis and that this animal is an adequate tool for this sort of experimental work.

Animals