The travails of psychiatrists.
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Biomedical subjects
Publications and source records attributed to J H Masserman.
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Alcohol selection and emotionality were examined in rhesus monkeys with frontal cortical ablations which had been subjected to stress via an "uncertainty" paradigm. Uncertainty produced a higher selection of alcohol as compared to nonstress situations. Controls and dorsolateral subjects when exposed to uncertainty selected more of an alcohol solution than either orbital stressed or control-nonstressed animals. Emotionality changes during alcohol-loading and control conditions were measured by recording the number of aggressive or aversive behaviors. Dorsolateral ablations increased the number of aggressive responses while decreasing the number of retreats in the alcohol-loading condition. In the other groups, alcohol loading did not affect the incidence of aggressive or aversive behaviors although they exhibited more retreats than advances across both conditions. Control-nonstressed subjects yielded the lowest number of total aggressive behaviors and the highest number of total retreats.
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Animals subjected to seemingly insoluble conflicts of motivation and difficulties of adaptation develop persistent "neuroses" or "psychoses" characterized by dramatic manifestations of anxiety, phobias, compulsions, and "dereism". Of all techniques of therapy investigated, the following were found to be variously effective in alleviating the disordered behaviour: (1) rest and change of milieu, (2) diminution of motivational stress, (3) spontaneous re-exploration, (4) forced solution of the conflict, (5) association with "normal" animals, (6) guided retraining and individualized re-experience, (7) drugs such as alcohol or the barbiturates that blunted or dissociated traumatic experiences, (8) cerebral electroshock, and (9) certain cerebral operations. Predictably, various combinations of these procedures were differently effective, depending on both the "constitution" and life experiences of the animal. The significance of these observations with regard to the biodynamics of clinical psychiatric treatment are discussed as well as those modes of psychotherapy which are "uniquely" human.