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Biomedical subjects

J H Kronman

Publications and source records attributed to J H Kronman.

At least 37 records · Page 2Linked to original sources
PubMed1979

Microbiologic evaluation of poly-HEMA root canal filling material.

This study was designed to determine whether poly-HEMA root canal filling material can support bacterial growth. Eight different microorganisms were tested against the polymerized material, as well as against the powder and paste components of the unpolymerized material. The results establish that this root canal filling material does not support bacterial growth.

Acrylates↗
PubMed1979

Scanning electron microscope study of a new irrigation method in endodontic treatment.

The effectiveness of a newly developed perforated endodontic irrigation needle, with its distal aperture sealed, was compared to conventional endodontic irrigation procedures. In all instances 5 percent sodium hypochlorite was used since the delivery system, rather than the irrigant, was being evaluated. A base line group in which all soft tissue was described was also included. The results indicate that the perforated endodontic irrigation needle is a very effective instrument for the cleansing of instrumented root canals.

Dental Instruments↗
PubMed1979

Poly-HEMA sponge: a biocompatible calcification implant.

Poly-hydroxyethyl methacrylate (Poly-HEMA) was investigated for biocompatibility and calcification potential. S.C. and I.M. implants and transplants to subperiosteal sites were examined. The material was judged to be tolerated by the host tissue since no inflammatory or degenerative changes were observed. This study established that calcification does occur. This calcification does not simulate bone formation; osteoblasts were not observed. The x-ray diffraction pattern resembles that of calcium hydroxyapatite.

Acrylic Resins↗
PubMed1977

The zygomatic arch and its possible influence on craniofacial growth and development.

This study was designed to investigate the role of the zygomatic arch and craniofacial growth along the anteroposterior axis. One may conclude that: 1. Surgical intervention on the zygomatic arch results in a generalized inhibition of regional zygomatic arch growth. 2. When only one zygomatic arch is sectioned, the posterior root of the sectioned side appears to be displaced posteriorly. This is a possible result of the normal growth process proceeding without the restraints of an intact zygomatic arch. 3. A decrease in anteroposterior dimension occurs in the posterior zone as a result of surgical intervention. 4. Further studies to determine the influence of the zygomatic arch on transverse maxillary growth must be completed before any clear or complete concepts of its role in craniofacial growth and development may be more fully elucidated.

Animals↗
PubMed1977

Effects of GK-101 (NMG) and sodium hypochlorite on salivary amylase activity.

A study was designed to assess the effects of the sodium salt of N-monochloroglycine (NMG) and sodium hypochlorite on the activity of salivary amylase. Concentrations of each agent were varied to determine the concentration at which the threshold and total inhibition of enzyme would be obtained. The data indicated that NMG at concentrations of 0.10% (w/v) does not affect amylase activity, whereas sodium hypochlorite at concentrations of 0.05% (w/v) totally inhibits salivary amylase activity.

Amylases↗
PubMed1977

Evaluation of intracytoplasmic particles in histiocytes after endodontic therapy with a hydrophilic plastic.

The presence of granules within the cytoplasm of periapical tissue histiocytes had been observed in teeth which had a root canal overfilled with a hydrophilic plastic polymer. SEM examinations revealed these granules to be barium sulfate, which was added to the polymer for radiopacity. X-ray spectra revealed strong calcium peaks in bone adjacent to the histiocytes, which showed strong barium peaks. In addition, between the histiocytes and the bone a greater concentration of calcium was seen. Because the histiocytes and not the plastic polymer contained barium sulfate, the evidence for this material's biocompatibility is greatly enhanced.

Animals↗
PubMed1976

A preliminary report on a chemomechanical means of removing caries.

Extensive testing for the safety of the GK-101 solution was conducted with experimental animals. An Investigational New Drug permit was awarded by the Food and Drug Administration before clinical studies. Subsequently, two studies--one double-blind and one open--were conducted to determine the safety and caries-removing efficacy of a 0.05% solution of N-monochloroglycine (GK-101) on clinical subjects, as well as to study the technique for such a procedure. In the double-blind study, the efficacy, as shown by ratings for caries removal, of GK-101 applied under pressure was significantly greater than that of the placebo solution of normal saline (P less than 0.01). Both treatment groups were comparable with respect to the age distribution, pretreatment intraoral examination results, and past history. No drug-related reactions were reported by patients in either group. On the basis of caries removal results in the open study, GK-101 solution, in conjunction with the pump system, was found to be effective as determined by the investigator. The caries in all but one of the 61 lesions treated with GK-101 was rated as "total removal" or as "almost total to total" removal. Approximately 77% of the patients treated with GK-101 experienced neither pain nor an odd taste. Any pain reported was always described as "slight" or "little." The drug is currently being further tested for safety and efficacy.

Adult↗