Endoscopic system for simultaneous visual examination and electronic detection of fluorescence.
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Bronchoscopes↗
Biomedical subjects
J H Kinsey
Publications and source records attributed to J H Kinsey.
Physics and technical considerations in the design of the DSR: a high temporal resolution volume scanner.
A multiple x-ray source, high-speed, transaxial scanner system (DSR) is about to undergo evaluation studies. The capability for programmable scanning modes and operator-interactive retrospective reconfiguration of scan data makes the DSR a very powerful research tool. The physics and technological basis for system design and selection of several major components of the DSR scanner are discussed.
Humans↗
Computed tomographic imaging of the heart: the dynamic spatial reconstructor.
A particularly important potential value of the Dynamic Spatial Reconstructor approach is that all the above data will be obtainable from a single injection of contrast agent into the right ventricle or pulmonary artery. On the basis of preliminary experimental data, a concentration of at least 80 mg of iodine per ml of contrast agent should be present in the aortic root for adequate opacification of the coronary arteries and myocardium; a bolus of at least 0.5 ml of contrast medium per kg, injected into the venous circulation, is required. As high-speed, volumetric imaging, computed tomographic scan machines such as the Dynamic Spatial Reconstructor become available with higher density resolution, perhaps a single injection of contrast agent into the right atrium or even a peripheral vein may be adequate to obtain all these measurements.
Animals↗
The DSR -- a high temporal resolution volumetric roentgenographic CT scanner.
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Animals↗
Clinical application of a new endoscopic technique for detection of in situ bronchial carcinoma.
Hematoporphyrin is preferentially concentrated by cancer tissue and therefore is a potentially useful chemical marker. This report demonstrates the effectiveness of a photoelectric hematoporphyrin fluorescence detector used simultaneously with flexible fiberoptic bronchoscopy as a means of detecting and localizing bronchogenic carcinoma. The detector generates an audio signal when fluorescence is within the visual field of the bronchoscope. Of interest is that an audio signal was generated which indicated hematoporphyrin fluorescence in areas where no mucosal abnormality had been seen. These areas proved to be carcinoma in situ.
Aged↗
Detection of hematoporphyrin fluorescence during fiberoptic bronchoscopy to localize early bronchogenic carcinoma.
Photoelectric detection of fluorescence from hematoporphyrin-containing "occult" bronchogenic carcinoma is a potentially useful technique for localizing and delineating such cancers. A method is presented which would enable use of a fluorescence-detection system simultaneously with conventional illumination during flexible bronchofiberscopic examination. Preliminary data suggest that quantities of hematoporphyrin as small as 5 picograms can be detected on the surface of tumors by this method.
Bronchoscopy↗
Hematoporphyrin-derivative phototherapy for local treatment of cancer of the tracheobronchial tree.
In this paper the potential use of hematoporphyrin-derivative (HpD) phototherapy in the local treatment of bronchogenic carcinoma is discussed. Ten patients with cancer involving the tracheobronchial tree have completed at least one course of HpD-mediated laser phototherapy administered by means of the flexible fiberbronchoscope. Complete response was obtained in four cases, and in each case the tumor was small and superficial. Larger tumors with greater degrees of invasion showed only a partial response. Two patients with tumors eroding through the bronchial wall died following treatment. It appears that HpD phototherapy may be useful for control of only small, superficial squamous cell carcinomas of the tracheobronchial tree and only those within the range of the flexible fiberbronchoscope.
Bronchial Neoplasms↗
Mayo Clinic and Medical School Biodynamics Research Unit.
The facilities that make up the Mayo Biodynamics Research Unit include the dynamic spatial reconstructor (DSR), which when fully operational will generate raw data at 200 million samples per second. Processing of these data will require a computer capable of several billion arithmetic operations per second.
Biomechanical Phenomena↗