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Biomedical subjects

J H Kelly

Publications and source records attributed to J H Kelly.

At least 73 records · Page 4Linked to original sources
PubMed1981

Physical evidence for the dimerization of the triphosphopyridine-specific isocitrate dehydrogenase from pig heart.

The TPN-linked isocitrate dehydrogenase from pig heart has been purified to homogeneity using blue Sepharose CL-6B as the only column chromatographic step and subsequently crystallized. Molecular sieve chromatography and analytical ultracentrifugation showed that the enzyme dimerizes in response to magnesium DL-isocitrate. TPNH or EDTA also brought about this effect, whereas TPN+ did not. The molecular weight of the monomer was 60,000 +/- 2,500 with an s20,w of 4.8 +/- 0.1 and a Stokes radius of 29 A. The molecular weight of the dimer was 115,000 +/- 5,000 with an s20,w of 6.7 +/- 0.2 and a Stokes radius of 39 A. Active enzyme centrifugation showed that the dimer was the active species in the oxidative decarboxylation of isocitrate.

Animals↗
PubMed1981

Alternatives to anterior-posterior packs for epistaxis.

This paper describes two alternatives to a conventional anterior-posterior pack for control of posterior epistaxis. Both methods involve occluding the posterior choana with finger-cot packs introduced through the anterior nares. These have proved effective in controlling bleeding with significant reduced morbidity.

Epistaxis↗
PubMed1981

Management of nasal septal abscess.

Nasal septal abscesses are uncommon. Sixteen cases from the Massachusetts Eye and Ear Infirmary were reviewed retrospectively and are presented. The diagnosis, bacteriology, and pathophysiology are discussed. Immediate therapy is indicated to avoid cosmetic deformity or intracranial infection. Treatment is based on diagnostic needle aspiration, antibiotic coverage and surgical drainage.

Abscess↗
PubMed1981

The association of a hearing deficit with Larsen's syndrome.

A retrospective study of 45 cases of Larsen's syndrome reported since 1950 reveals a prevalence of cleft palate in this disease of about 30 per cent. Although cleft palate abnormalities in infancy invariably cause otitis media, which may result in hearing loss, only rarely have hearing deficits been reported in association with Larsen's disease. This paper reports the occurrence of a bilateral conductive hearing loss secondary to otitis media, and possible ossicular abnormality in a five-year-old with cleft palate and Larsen's disease and considers the possibility that this otologic problem may be more prevalent than currently suspected.

Abnormalities, Multiple↗
PubMed1980

Inverted papilloma of the nasal septum.

Inverted papillomas are primarily lesions of the lateral nasal wall, but similar papillomas have been observed on the nasal septum. There is controversy as to whether papillomas on the septum should be considered differently from those of the lateral nasal wall and paranasal sinuses. A review of the records of the Massachusetts Eye and Ear Infirmary, Boston, disclosed 18 cases of inverted papilloma of the nasal septum that were treated before January 1968 and January 1980. The histologic diagnosis of inverted papilloma was confirmed by pathologists who examined histologic slides from these cases; these slides had been randomly mixed with slides of nasal vestibule squamous papillomas and slides of inverted papillomas of the lateral nasal wall. Squamous papillomas of the vestibule were readily distinguished microscopically from inverted papillomas of the septum and lateral wall that were histologically similar. The clinical course of these patients suggests that inverted papillomas of the nasal septum behave like inverted papillomas elsewhere and require wide surgical excision and careful follow-up.

Adult↗
PubMed1980

An unusual foreign body of the tongue masquerading as malignancy.

Foreign bodies within the tongue are a rare finding. The history is often not helpful as it is usually remote. Presented is a case of an unusual foreign body in the tongue which masqueraded as a malignancy. The differential diagnosis of an asymptomatic tongue swelling or tongue pain should include foreign body.

Diagnosis, Differential↗