Biomedical subjects

J H Helmers

Publications and source records attributed to J H Helmers.

25 records · Page 2Linked to original sources

PubMed1982

Double-blind comparison of the postoperative respiratory depressant effects of alfentanil and fentanyl.

Alfentanil was compared with fentanyl in a double blind study of 90 female patients undergoing laparoscopic sterilizations. The analgesic was combined with droperidol and etomidate for induction and with etomidate, nitrous oxide and occasional increments of succinylcholine for maintenance of anesthesia. Twenty-four percent of the patients required reversal of postoperative respiratory depression after fentanyl compared with 7% after alfentanil (p = 0.042). When the last dose of analgesic had been given more than 10 minutes before the end of the operation, none of the alfentanil patients required reversal of respiratory depression while under the same circumstances 26% of the fentanyl patients required naloxone (p = 0.005). Awakening was delayed in all patients, exceeding a mean time of 20 minutes in both groups. However, 84% of patients were alert on awakening after alfentanil compared with 62% of patients after fentanyl (p = 0.032). Duration and quality of postoperative analgesia were similar in both groups. Cardio-vascular stability was satisfactory in all patients and side effects were minor and infrequent.

Adult↗

PubMed1981

A comparison of alfentanil and fentanyl in short operations with special reference to their duration of action and postoperative respiratory depression.

Ninety women undergoing short gynaecological operations were included in a double-blind comparison of fentanyl and alfentanil, a structurally related and very short-acting narcotic analgesic. Anaesthesia was induced by methohexitone followed by a double-blind injection of either alfentanil (0.5 mg/ml) or fentanyl (0.05 mg/ml). Depending on the expected duration of the procedure 3 or 5 ml of the analgesic was given. For the same duration of anaesthesia, respiratory depression had to be reversed in 11% of the alfentanil and 51% of the fentanyl group and the time of awakening was significantly shorter in the alfentanil group. Cardiovascular parameters remained stable with both analgesics. There were no troublesome side-effects.

Adolescent↗

PubMed1981

Pain and myoclonus during induction with etomidate. A double-blind, controlled evaluation of the influence of droperidol and fentanyl.

To compare the incidence and severity of pain and myoclonus, 83 patients, premedicated with oral diazepam, received a double-blind intravenous injection of either droperidol 5 mg, fentanyl 0.1 mg or normal saline two minutes before induction with etomidate. The only statistically significant difference between the three groups was the decreased incidence of involuntary movements in the fentanyl and the droperidol group as compared with the normal saline group.

Adolescent↗

PubMed1981

An evaluation of etomidate in total intravenous anesthesia (TIVA).

In 47 adult patients undergoing either microlaryngoscopy or bronchoscopy, anesthesia was maintained with a continuous etomidate infusion after induction with etomidate and spraying the vocal cords and trachea with 10% xylocaine. The patients breathed air spontaneously throughout the procedure, oxygen being added if necessary. It is claimed that this technique provides good, safe and convenient anesthesia. An additional advantage in cases of microlaryngoscopy is that mobility of the vocal cord is retained.

Adolescent↗

PubMed1980

The efficacy of Domperidone (R 33812) in the treatment of postoperative vomiting. A double-blind study with a placebo.

One hundred patients (14-82 years) were given either domperidone 10 mg I.V. or a placebo after they had vomited postoperatively. The patients were then observed for six hours. A supplementary injection of domperidone 10 mg I.V. from an open supply was given if required. In the placebo group 47.9% of patients needed another injection but only 25% of patients in the domperidone group (p less than 0.01). Vomiting occurred later after domperidone than after the placebo (p less than 0.01). At the end of six hours 74% of patients in the domperidone group had no recurrence of vomiting compared with 38% in the control group. In this study neither vomiting nor the efficacy of domperidone were found to be related to the type of surgery, the type of anaesthetic or the physical status (ASA I-III) of the patient (p greater than 0.05).

Adolescent↗

PubMed1979

Domperidone (R 33 812) as an antiemetic in the treatment of postoperative vomiting. A double blind comparison between two different dosages (4 mg and 10 mg).

Forty seven patients received either 4 mg or 10 mg domperidone I.V. in a double blind study after they had vomited postoperatively. The patients were then observed for six hours. If necessary, the same dose of domperidone was repeated double blind but not during the first hour. When the two groups were compared there was little difference between them for the first half hour after the initial dose, thereafter both the frequency and severity of vomiting was reduced in the 10 mg group. Also fewer patients in the 10 mg group needed a second injection. These differences were statistically significant (p less than 0.05).

Adolescent↗

PubMed1977

Preliminary report of domperidone (R 33182), a new antiemetic compound. A pilot study.

The effect of domperidone (R 33 812), a new antiemetic, was studied in 27 patients presenting with postoperative vomiting and staying for at least six hours in a recovery room. All patients received 4 mg domperidone intravenously because of the vomiting. Nineteen patients were fully protected during the subsequent 6 hours observation period, 8 patients required a second 4 mg-dose: only one of these 8 patients was not protected at all. No side-effects were observed.

Adult↗