Biomedical subjects

J H Graham

Publications and source records attributed to J H Graham.

At least 73 records · Page 4Linked to original sources

PubMed1977

Ultrastructure of atypical fibroxanthoma.

Electron microscopic examination of an atypical fibroxanthoma (AFX) confirmed the fibrohistiocytic nature of this lesion. Ultrastructural evidence suggested a transition from fibroblasts to large giant cells with intermediate forms exhibiting features of both. A comparison of AFX ultrastructural features to those of other similar neoplasms suggested a possible relationship to malignant fibrous histiocytoma. As diagnosed by light microscopy, AFX probably represents a spectrum of neoplasms; this concept is discussed. It is urged, when possible, that electron microscopy be performed on lesions diagnosed as atypical fibroxanthoma since ultrastructure studies represent the most valid basis on which a correct diagnosis can be made.

Aged↗

PubMed1977

Multicentric dermal-type cylindromas of the parotid glands in a patient with florid turban tumor.

Dermal-type cylindromas of parotid glands in a patient with turban tumor, and various adnexal tumors, represent a rare diathesis, apparently not reported previously. A Caucasian man, born in 1916, had a scalpectomy for turban tumor in 1957. In 1957, 1960, and 1974, dermal type cylindromas were excised from portions of both parotid glands, developing from intercalated and striated ducts; they were considered benign, based on long term followup. Adrexal tumors included multiple dermal cylindromas, trichoepitheliomas, eccrine spiradenomas, and Bowen's disease, and occurred on almost all skin surfaces. In November, 1976, a portion of a right parotidectomy included a 3.5 X 3-cm malignant tumor having the characteristics of an invasive poorly differentiated spindle cell epidermoid carcinoma, which showed no evidence of originating from a malignant basal cell tumor. Several encapsulated and developing benign basal cell tumors were included in the specimen. Dermal-type cyclindromas of the parotid gland are considered to be a variant of basal cell ademona, or monomorphic adenoma, basal cell type, since they consist of similar cell components, although of somewhat different arrangement and with prominent focal deposition of hyaline. Dermal-type cylindromas should be excised conservatively as they appear. They must be differentiated from adenoid cystic carcinoma, which is an infiltrating neoplasm and requires a radical surgical approach.

Adolescent↗

PubMed1977

Papulosquamous eruptions: usefulness of biopsy in establishing diagnosis.

Papulosquamous dermatoses are caused by a variety of etiologic agents. T. rubrum in particular can produce clinicopathologic changes which mimic a spectrum of disorders. Of these, some are papulosquamos in character. Whenever patients are seen with atypical papulosquamous dermatoses, the clinical differential diagnosis should always include dermatophytosis caused by T. rubrum. If skin scrapings for direct microscopic examination and culture studies are negative, a biopsy should be seriously considered as the best procedure to aid in making the correct diagnosis. Periodically, tissue diagnoses of fungal disease are made by dermatopathologists when the problem has not even been suspected by the clinician. Clinicians and pathologists should maintain a high index of suspicion for the disease spectrum which T. rubrum can cause in the human host. T. rubrum represents a great mimicker of cutaneous diseases similar to eruptions caused by Treponema pallidum and drugs. Information T. rubrum and methods have been reported.

Adult↗

PubMed1976

Tumor-induced acute pancreatitis.

Primary neoplasms of the pancreas and tumors metastatic to the pancreas are capable of initiating an epidode of acute pancreatitis severe enough to cause the development of a pancreatic pseudocyst and ascites. There are now three case reports of bronchogenic carcinoma metastatic to the pancreas causing acute pancreatitis. In the present case, there was histological evidence of rupture of pancreatic ducts by tumor and obstruction of ducts by nests of tumor cells.

Acute Disease↗

PubMed1975

Analysis of individual thyroid tablets.

A procedure was developed for the assay of individual thyroid tablets or composite samples equivalent to as little as 0.033 g (0.5 gr) of thyroid. The sample is ignited in a closed atmosphere of oxygen and, after a series of redox reactions, the iodine is determined spectrophotometrically as the triiodide ion. The results agree well with those obtained by the USP thyroid tablet assay.

Methods↗

PubMed1975

Macular amyloidosis with localized amyloidosis of upper air passages.

A patient with primary amyloidosis of the upper air passages was found to have cutaneous macular amyloidosis. A review of the literature indicates that this may represent the first report of these two uncommon forms of amyloidosis occurring in the same individual. Biopsy material from the nasopharynx, tonsillar areas, larynx, trachea, and skin showed amyloid in the tissue sections. Special stains were used and polariscopic studies were performed, and the hyalin material met the established criteria for amyloid. Studies of tissues from other parts of the body of this patient failed to demonstrate amyloid.

Amyloidosis↗

PubMed1974