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Biomedical subjects

J H Goodman

Publications and source records attributed to J H Goodman.

62 records · Page 4Linked to original sources
PubMed1975

Stimulation of the dorsal spinal cord for treatment of intractable pain: a preliminary report.

Electrical stimulation of the nervous system has been advocated as a means of alleviating pain in situations in which more conventional methods have been ineffective. A chronically implanted electrode on the dorsal surface of the spinal cord may prove to be a valuable adjunct to the neurosurgeon's armamentarium for pain control in selected individuals. The physiologic basis for this action is unclear but has been related to Melzack and Wall's gate control theory. This preliminary report deals with a series of patients treated with implanted dorsal cord stimulators.

Adult↗
PubMedDate not supplied

The surgery of benign and malignant neoplasms adjacent to or involving the skull base.

A group of patients who have undergone resection of benign and malignant neoplasms, either adjacent to or through the skull base, were evaluated to determine whether the long-term results justify the risks of such surgery. A total of 37 patients underwent 55 operations in a 6.5-year period from December 1979 to July 1986 at The Ohio State University. An analysis of the operative, perioperative, and long-term complications demonstrates that surgery is well-tolerated. The disease-free interval and survival rates for both benign and malignant neoplasms are encouraging and demonstrate curative potential even for those patients presenting with recurrent malignancies extending through the base of the skull. The interdisciplinary approach evaluated in this study is an effective modality in the treatment of skull base tumors, conferring a favorable risk-benefit ratio.

Adolescent↗
PubMedDate not supplied

Kindled seizures elevate blood pressure and induce cardiac arrhythmias.

The effect of kindled seizures on the cardiovascular system was examined in amygdaloid kindled rats. The most prominent cardiovascular response during a generalized kindled seizure was an abrupt 50% increase in mean arterial pressure (MAP) lasting 20-30 s after initiation of the seizure. Superimposed on this change in blood pressure (BP) was a profound bradycardia characterized by a rate about half that recorded before stimulation. Changes in heart rate (HR) and BP observed during amygdaloid kindled seizures were similar to those observed during secondary spontaneous seizures. These effects apparently are independent of the kindling stimulus because stimulus-induced cardiovascular changes were not present at the beginning of the kindling process. These results suggest that the kindling seizure model is useful to study the underlying mechanisms of seizure-induced cardiac arrhythmias and possibly the clinical phenomenon of sudden unexplained death in epileptic patients.

Animals↗
PubMedDate not supplied

Gas bubbles in polymethylmethacrylate cranioplasty simulating abscesses: CT appearance.

Polymethylmethacrylate (PMMA) cranioplasty procedures were performed on 20 patients over a 2-year period. Nine of these patients had a total of 17 CT examinations, performed when clinically indicated. On 16 of the 17 CT scans, the appearance of the cranioplasty plate was characteristic of plates with gas bubbles. The appearance of these bubbles was stable over an extended period of time, ruling out clinical reasons for this appearance. The original interpretations of the CT scans were variable, inconclusive, or even erroneous. An understanding of the application of PMMA plates and their characteristics is necessary to accurately interpret the CT appearance of the PMMA cranioplasty plate.

Abscess↗