Search PubMed⌕ Search

Biomedical subjects

J H Fox

Publications and source records attributed to J H Fox.

63 records · Page 4Linked to original sources
PubMed1975

Dementia in the elderly--a search for treatable illnesses.

Forty patients with senile dementia were evaluated prospectively with laboratory and radiologic investigations, including computerized axial transverse tomography. Five patients were believed to have potentially treatable illnesses causing the dementia. After treatment, the dementia in one patient with hypothyroidism was completely resolved. One patient with pernicious anemia was markedly improved, and a second patient with hypothyroidism was somewhat improved. One patient with a brain tumor was not treated, and a severely demented patient with possible normal pressure hydrocephalus died shortly after shunting without improvement. The discovery of these unsuspected illnesses and the gratifying response to treatment in some suggests the importance of systematic evaluation in all patients with senile dementia.

Aged↗
PubMed1975

Use of computerized tomography in senile dementia.

Computerized tomography was used to evaluate 35 patients with senile dementia and proved to be a simple and practical screening procedure. Those patients with moderate or severe cerebral atrophy had a poorer short-term prognosis than those with questionable or mild atrophy. Two patients with potentially treatable illnesses (hypothyroidism and pernicious anaemia) and only questionable atrophy had reversal of the dementia with treatment. A single patient with moderate atrophy had a potentially treatable illness (hypothyroidism) which only partially resolved. Those patients with dementia but relatively little atrophy by computerized tomography may represent a unique group with a better prognosis who require particularly careful evaluation for potentially treatable illnesses.

Aged↗
PubMed1975

Effect of aging on brain respiration and carbohydrate metabolism of Syrian hamsters.

Syrian hamsters were used to study the effect of aging on brain slice respiration and metabolism. Young animals (average age 8 months) and old animals (average age 18 months) were incubated under standard conditions with the following parameters being measured: oxygen uptake, 14CO2 production, glucose utilization, lactate and pyruvate formation. No differences were found in the two groups. It is still very likely that subtle differences exist but can only be documented under conditions of metabolic stress.

Aging↗
PubMedDate not supplied

Perspectives on the continuity perspective.

This paper explores the strengths and limitations of the continuity perspective on aging. First, current usages of the concept are delineated. Then available literature is reviewed for evidence that continuity is in fact characteristic of the aging process and for indications that it is positively related to morale in old age. While lack of comparable data makes conclusions somewhat tentative, it appears that discontinuity is as characteristic of aging as continuity and that continuity may actually be maladaptive in many cases. Components of a conceptual definition of continuity are discussed, and suggestions are made for operationalization and more rigorous investigation of the concept.

Adaptation, Psychological↗
PubMedDate not supplied

Malaria in a captive emu (Dromaius novaehollandiae) from Florida.

Severe anemia and intraerythrocytic stages of an unusual Plasmodium sp. were identified in the blood of a 5-month-old female emu (Dromaius novaehollandiae) that had a 4-week history of malaise. Examination of blood taken 3 days prior to the death of the bird revealed a packed cell volume of 10%. Erythrocytes showed a marked regenerative response. Approximately 4% of erythrocytes had intracytoplasmic inclusions, mainly within immature cells, resembling malarial parasites. The schizonts were a combination of the Haemamoeba and Huffia subgenera type with 8-16 merozoites in mature forms. The gametoctyes were elongate. The abnormal morphology was probably a reflection of a new host-parasite relationship. Exoerythrocytic parasite stages were not identified at necropsy. The anemia was tentatively attributed to the Plasmodium infection.

Animals↗