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Biomedical subjects

J H Epstein

Publications and source records attributed to J H Epstein.

97 records · Page 6Linked to original sources

Avascular bone necrosis. A complication of long-term corticosteroid therapy.

A patient with pemphigus vulgaris, treated with long term corticosteroids, developed avascular necrosis of the head of the femur and humerus, bilaterally. This patient emphasizes the fact that the use of corticosteroids in dermatologic disorders may be a predisposing cause in avascular necrosis, and that this is another side effect of long-term corticosteroid therapy. This patient is particularly remarkable in that both hips and both shoulders were involved.

Adrenocorticotropic Hormone↗

Porphyria cutanea tarda symptomatica (PCT-S). A study of the effect of phlebotomy therapy.

The effect of phlebotomy therapy on porphyrin metabolism was evaluated in five patients with porphyria cutanea tarda symptomatica (PCT-S). The removal of 2,500 to 4,500 cc over a three to four and one-half month period resulted in a marked reduction in urine and fecal uroporphyrin excretion in three of the subjects. Clinical improvement accompanied the chemical response in each case. In one patient, the induced chemical and clinical remission has persisted for six months without further treatment.

Adult↗

Potential exposure to Australian bat lyssavirus, Queensland, 1996-1999.

Two human deaths caused by Australian bat lyssavirus (ABL) infection have been reported since 1996. Information was obtained from 205 persons (mostly adults from south Brisbane and the South Coast of Queensland), who reported potential ABL exposure to the Brisbane Southside Public Health Unit from November 1,1996, to January 31, 1999. Volunteer animal handlers accounted for 39% of potential exposures, their family members for 12%, professional animal handlers for 14%, community members who intentionally handled bats for 31%, and community members with contacts initiated by bats for 4%. The prevalence of Lyssavirus detected by fluorescent antibody test in 366 sick, injured, or orphaned bats from the area was 6%. Sequelae of exposure, including the requirement for expensive postexposure prophylaxis, may be reduced by educating bat handlers and the public of the risks involved in handling Australian bats.

Adolescent↗