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J H Clorius

Publications and source records attributed to J H Clorius.

52 records · Page 3Linked to original sources
PubMed1985

Computed tomography for staging bronchogenic carcinoma.

One hundred and fourty patients with a primary lung neoplasm underwent transmission computed tomography (TCT) for staging prior to therapy. TCT results were compared with the post-operative T- and N-stage. The preoperative TCT examination correctly classified 70% of all tumors. 73% of T1, 63% of T2 and 74% of T3 tumors did not require restaging after surgery. TCT correctly staged 80% of the patients with respect to the N-stage. Ninety-seven percent of the patients with N0, 42% with N1 and 79% with N2 tumors were correctly classified. Serious over- and understaging was observed in patients with centrally located bronchogenic carcinoma. This was due to the difficulty of distinguishing tumor tissue from enlarged lymph nodes and atelectasis.

Adenocarcinoma↗
PubMed1984

Single photon emission computerized tomography (SPECT) for estimates of liver and spleen volume.

A simple procedure is described for estimates of liver and spleen volume using the imaging data obtained during single photon emission computerized tomography ( SPECT ). In vitro studies were carried out to obtain correlation and regression coefficients for volume estimations. Using these regression coefficients, we estimated liver and spleen volumes in 50 patients. Phantom and organ volumes were also calculated from transmission computed tomography (TCT), whose results served as the reference procedure against which SPECT -determined volumes were compared. The influence of radiotracer uptake on scintigraphic volume predictions was also assessed. For the in vitro measurements, SPECT volumes predicted the true volumes with a coefficient of correlation of 0.997. When in vivo SPECT volumes were correlated with those obtained by TCT, a coefficient in excess of 0.9 was achieved. SPECT volume determinations proved to be influenced by organ uptake of tracer; high liver uptake and low spleen-to-liver ratios gave the best results. It is concluded that SPECT imaging offers access to rapid and exact volume estimation.

Humans↗
PubMed1983

Prognostic value of post-transplant hippurate scintigraphy.

131Iodine hippurate sequential scintigrams obtained after transplantation contain prognostic information about the long-term development of a graft. Results of 131 131iodine hippurate sequential scintigrams made within 48 hours after graft implantation were compared to the graft status 2 years after transplantation. Hippurate uptake and transport were rated on a 4-step scale. Disturbed hippurate uptake and abnormal tracer transit were associated with increased frequency of early graft destruction and with a high frequency of chronic rejection. The chi-square test demonstrated a significant relationship between results of the initial hippurate scintigrams and long-term graft development.

Adolescent↗
PubMed1983

A Ga-68-labeled tetrabromophthalein (Ga-68 BP-IDA) for positron imaging of hepatobiliary function: concise communication.

We describe the chemical synthesis of an iminodiacetic-acid-substituted tetrabromo-o-cresolphthalein (BP-IDA), which complexes Ga-68 tightly. The liver uptake, bile excretion, and urinary excretion of the complex were examined in rats. Maximum liver uptake reached 60%, and 1-hr cumulative bile excretion was 75% of injected dose. Urinary excretion in rats with ligated common bile duct remained below 1%. Competitive action of exogenous bilirubin on hepatobiliary excretion of the Ga complex was less pronounced than that of bromosulfophthalein. The absolute activity determination of the positron emitter Ga-68, the high accumulation in the liver, the low urinary excretion, and the weak competition from exogenous bilirubin are promising features of this radiopharmaceutical for the quantitative study of hepatobiliary function.

Animals↗
PubMed1983

The exercise renogram. A new approach documents renal involvement in systemic hypertension.

Hippurate functional scintiscans were obtained in 51 hypertensive patients and in 15 controls. We investigated the influence that posture and exercise have on hippurate kinetics in patients with hypertension. A posture- or exercise-induced disturbance of renal hippurate transport was sought. All persons were examined in prone and standing positions, as well as during exercise. When prone and upright renograms were compared, 24% of the hypertensives demonstrated bilateral orthostatic renal dysfunction. Exercise caused the hippurate transport disturbance to increase. Fifty-seven percent of all hypertensives developed evidence of marked, bilateral, renal dysfunction during ergometric stress, so that exercise renography was shown to be a more sensitive test of the presence of transient tubular dysfunction in hypertension than the standing renogram. In normotensive controls the hippurate functional scintigram failed to be influenced by posture and exercise. The results suggest presence in hypertension of transient, posture- and exercise-mediated alterations of renal cortical blood flow.

Adult↗
PubMed1982

Radioisotope therapy of cystic craniopharyngomas.

Eighteen patients suffering from cystic craniopharyngeoma were treated with intracavitary irradiation. The beta-emitting radioisotope 90y (2.25 MeV) was instilled into the cyst following stereotactic puncture of the space-occupying lesion. The surgical approach was planned using angiograms and reconstructed transmission computer tomography (TCT) coronal and saggital sections. Therapy was devised to deliver 20,000 rad to the cyst's wall. Eleven patients received follow-up TCT examinations after four months. Eight of 11 patients had a significant volume decrease in the craniopharyngeoma cyst. In two patients, the cystic volume remained unchanged; one had progression of disease. It is concluded that the intracavitary treatment of cystic craniopharyngeoma will result in a reduction of the size of the space-occupying lesion.

Adolescent↗
PubMed1982

Single-photon emission computed tomography (SPECT) for assessment of hepatic lesions.

Single-photon emission computed tomography (SPECT) and conventional scintigraphy were compared in 130 patients examined to assess hepatic involvement in malignant disease. Transmission computed tomography (TCT) served as the reference method against which SPECT and conventional scintigraphy were compared. The sensitivity of SPECT was calculated for lesions grouped according to diameter as well as location. The Bayesian theorem was used to assess the reliability of both SPECT and conventional scintigraphy. SPECT identified only 52% of lesions with a diameter of 1.5-2.0 cm. It was also shown that the sensitivity of SPECT was lowest for small lesions in the middle third of the liver. A comparison of the final diagnosis demonstrated that SPECT had greater sensitivity, specificity, and accuracy than conventional scans, and is superior at low disease prevalence. At high disease prevalence, SPECT has a lower rate of false negatives. SPECT appears to be the superior imaging modality for evaluation of the liver in malignant disease.

Bayes Theorem↗
PubMed1981

Hypertension associated with massive, bilateral, posture-dependent renal dysfunction.

Hippurate function scintiscans were obtained in prone and standing positions in a group of 76 patients with concurrent hypertension and nephroptosis. TWelve of these patients had massive, bilateral disturbance of intrarenal hippurate transport in the standing position; hippurate transport was normal in the prone position. This pattern was present in only three of 120 normotensive patients with nephroptosis. To investigate the importance of nephroptosis, 87 other hypertensive patients were examined. Eighteen of these patients demonstrated posture-dependent tubular dysfunction, but only four had nephroptosis. The results suggest a direct relationship between bilateral posture-dependent tubular dysfunction and hypertension.

Hippurates↗
PubMed1980

Posture-induced disturbance of pertechnetate flow and I-123 iodohippurate transport in some renal graft recipients with hypertension.

Iodohippurate renography and rapid serial scintigrams with pertechnetate were done in 27 allograft recipients in supine and standing positions. Posture-dependent iodohippurate transport and/or disturbance of pertechnetate flow pattern was found in nine of those examined. Patients demonstrating these abnormalities were found to be hypertensive. We suggest a causal relationship between posttransplant hypertension and the described posture-induced alterations of tracer transit.

Female↗
PubMed1979

Renal graft evaluation with pertechnetate and I-131 Hippuran. A comparative clinical study.

This retrospective study compared standard clinical and biochemical data from 50 graft recipients against 533 I-131 Hippuran sequential scintigrams and 515 [99mTc]pertechnetate serial scintigrams. All grafts included in this study are cadaver kidneys. The majority of the studies were made during the early posttransplantation period. Anuria or oliguria of at least 4 days duration was seen in 18 patients. The study spans 574 days of oliguria during which 136 dual-tracer studies were made. I-131 Hippuran renography of functioning grafts was carried out 397 times, and the Tc-99m sequential scintigraphy 379 times. In all, 47 espisodes of actue rejection were registered clinically in functioning gfafrs, 36 of which were recognized during Hippuran renography and 38 with the pertechnetate study. False-positive errors were seen 12 times during renography. The study also demonstrated that furosemide will significantly and predictably influence renography and the pertechnetate study. This seems noteworthy since furosemide is extensively used in posttransplant management.

Adolescent↗
PubMed1978

Evidence of possible association of nephrolithiasis and nephroptosis.

Two separate populations, one consisting of 100 patients with renal stones and one consisting of 81 patients with nephroptosis were examined to determine whether an association may exist between excessive renal mobility and renal stone formation. The statistical analysis of the data suggests a direct relationship between nephroptosis and the occurrence of renal stones.

Adolescent↗
PubMed1978

[131I] Hippuran renography in the detection of orthostatic hypertension.

Scintigrams in prone and standing positions were done in 11 hypertensive women. All had nephroptosis with ventral rotation. On the basis of the renograms, seven patients were identified as suffering from orthostatic hypertension. Nephropexy resulted in normalization of blood pressure in six of the seven patients and normalization of the renograms of all seven. We believe that sequence scintigrams in prone and standing positions offer a simple method of identifying patients with orthostatic hypertension.

Adult↗
PubMed1977

Position dependent renogram changes of the mobile kidney.

The present study evaluates the isotope renograms, obtained in prone and upright position of 87 patients with 93 mobile kidneys. Scintiphotos were made to determine the extent of renal movement. The transient position abnormality of the kidney was compared to the position dependent isotope renogram changes. It was possible to describe three types of floating kidney each with a characteristic motion and position dependent function disturbance. One form of renal ptosis, ptosis with ventral rotation, was commonly associated with a 2nd phase renogram abnormality and with hypertension.

Adult↗
PubMed1976

[Clinical significance of kidney imaging in bone scintigraphy].

The results of the examination of 62 patients who had undergone skeletal scintigraphy with 18-F and a urologic examination, were evaluated to determine whether the 18-F incorporation in the kidneys might indicate the presence of renal disease. Patients with and without renal disease demonstrated a similar 18-F incorporation in the kidneys. Our data indicate that a side different 18-F renal activity is without clinical significance.

Bone Diseases↗