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Biomedical subjects

J H Baron

Publications and source records attributed to J H Baron.

At least 217 records · Page 12Linked to original sources
PubMed1972

A comparison of Boots and GIH secretin as stimuli of pancreatic secretion in human subjects with or without chronic pancreatitis.

The effects of single intravenous injections of 1 u/kg body weight Boots and 1 u/kg GIH secretin were compared in 10 male control subjects and five men with chronic pancreatitis. The duodenum was aspirated for the next hour in 4 x 10 minute and 1 x 20 minute fractions, and the volume, bicarbonate concentration, and tryptic activity were measured. The duodenal juice volume and peak bicarbonate output in response to GIH secretin 1 u/kg iv were double the responses to Boots secretin 1 u/kg, but tryptic activity was significantly less. The coefficients of variation of these measurements were not appreciably improved by expression of the results in terms of body weight. Measurements of bicarbonate concentration or enzyme output in the submaximal pancreatic function tests using Boots secretin 1 u/kg were of some use as diagnostic discriminants between normal subjects and patients with chronic pancreatitis. However, these measurements were of little value with the test using a near-maximal stimulus of 1 u/kg GIH secretin. Measurement of peak bicarbonate output is probably the best diagnostic discriminant, and discrimination is not improved by expression of the results on a body weight basis.

Bicarbonates↗
PubMed1971

Use of gastric function tests by British gastroenterologists.

A questionnaire was used to study the choice and use of gastric function tests by members of the British Society of Gastroenterology.Pentagastrin has largely replaced older drugs as the stimulant of choice for evoking maximal acid secretion. Insulin tests are being used in situations where they are unlikely to provide useful clinical information. Fewer physicians than surgeons measure gastric secretion, and they use tests less often. The reluctance of physicians to test patients with uninvestigated dyspepsia or gastric ulcer seems justified, but in patients having dyspepsia with negative x-ray films, or after gastrectomy or vagotomy, the greater investigative keenness of surgeons seems commendable. Only half the surgeons ever try to assess the completeness of their vagotomies, and in only one-third of this half is it their usual practice. Criticism is made of the practice of routine measurement of acid in patients with duodenal ulcer, and of the use of acid measurements to decide whether a patient should have surgery or which type of operation should be performed.

Journal Article↗
PubMed1971

Serum gastrin in duodenal ulcer. II. Effect of insulin hypoglycaemia.

Serum gastrin has been measured by radioimmunoassay in normal subjects and patients with proven duodenal ulcer in response to insulin hypoglycaemia in conjunction with manoeuvres to decrease the intragastric acidity. Insulin hypoglycaemia alone caused a rise in the serum gastrin level from 5 +/- 1.0 to 49 +/- 2.9 pg/ml in duodenal ulcer and from 17 +/- 5.6 to 42 +/- 7.7 pg/ml in normals. With complete intragastric neutralization of acid and the same stimulus, the rise in duodenal ulcer was from 5 +/- 1.3 to 128 +/- 13.6 pg/ml and in normals from 13 +/- 2.6 to 84 +/- 2.6 pg/ml. These studies suggest an increased production rate of gastrin in response to vagal stimulation in duodenal ulcer, and indicate the precise role of acid inhibition in the control of gastrin release and support the concept of both an increased ;G cell' mass and parietal cell mass in duodenal ulcer. They have also offered an explanation of the variable vagal stimulation of gastrin release in normal subjects.

Bicarbonates↗