Zidovudine-related thrombocytopenia simulating rapid growth of Kaposi's sarcoma.
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Biomedical subjects
Publications and source records attributed to J H Barnett.
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A patient with a nickel contact dermatitis also had discoid lupus erythematosus. The dermatitis acted as a Koebner-like reaction on the cutaneous lupus, which in turn caused progressive destruction of the earlobes.
Herpesvirus infections are among the most common and debilitating opportunistic infections in patients with acquired immunodeficiency syndrome (AIDS), and they may have atypical clinical features. We describe the cases of three patients with AIDS in whom atypical persistent ulcerative skin lesions developed as a result of varicella-zoster virus infection. Two patients had disseminated infection without a vesicular stage; one patient had underlying asteatotic eczema. All responded well to acyclovir. One patient was treated with azidothymidine, and typical dermatomal herpes zoster subsequently developed. The profound loss of helper T cell function in AIDS may lead to multiple abnormalities in local immune response to cutaneous herpesvirus infections and may be responsible for the atypical morphology and a prolonged course.
A patient with a lifelong linear porokeratosis was treated with a carbon dioxide laser. The laser was successful in removing the patient's hyperkeratotic plantar lesion. No recurrence has been noted in a 6-month follow-up visit. This report demonstrates another dermatologic condition that can be treated successfully with the CO2 laser.
We report on a young man with a congenital mutilating keratoderma in whom three epitheliomata cuniculata occurred during a two-year period. The clinical findings, associated disease states, and treatment of epithelioma cuniculatum (EC) are reviewed.
Many medications, including gold, antimalarials, quinidine, and thiazide diuretics have been implicated in lichenoid drug reactions. Chlorpropamide and tolazamide are sulfonylurea oral hypoglycemic agents, neither of which has previously been implicated in cutaneous lichenoid reactions. We report a case of lichenoid drug reaction related to both chlorpropamide and tolazamide.
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Erysipelothrix infections have been a well-known clinical entity for over a century. Only a few cases have been studied histologically, and the agent has rarely been cultured from infected patients. We present here a case of erysipeloid of Rosenbach, in which histologic study and electron microscopy document the presence of microorganisms. We also present a complete review of the clinical and pathologic features of Erysipelothrix infections and their treatment. Our observations suggest that Erysipelothrix rhusiopathiae is capable of producing L forms that may revert to a bacterial form and produce sepsis at a later time.
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Werner's syndrome is an adult progeria that predisposes affected individuals to various cutaneous and internal malignant neoplasms. Herein we report on a patient with Werner's syndrome who developed two primary melanocytic tumors.