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Biomedical subjects

J H Allison

Publications and source records attributed to J H Allison.

10 recordsLinked to original sources
PubMed1980

Alcohol acutely depresses myo-inositol 1-phosphate levels in the male rat cerebral cortex.

The effects of acute alcohol administration on myo-inositol and myo-inositol 1-phosphate levels in the male rat cerebral cortex were examined. At a dose of 3 g/kg, alcohol reduced myo-inositol 1-phosphate levels in the cortex by 60% within 30 min after its injection. A significant depression in myo-inositol 1-phosphate was found 5 min after the injection of alcohol, and maximal levels of depression occurred at 30 min. Levels of myo-inositol 1-phosphate remained significantly depressed for 6 hr and then gradually recovered, reaching normal values of 24 hr after the initial injection. There was an excellent inverse correlation (rxy = 0.96) between myo-inositol 1-phosphate levels and blood alcohol levels at all time intervals examined. Dose-response analyses indicated that the half-maximal (ED50) decrease in myo-inositol 1-phosphate levels occurred at a dose of 1.6 g/kg of alcohol. In contrast to these effects, myo-inositol levels were not significantly altered by any dose of alcohol at any time interval examined. Because of the rapidity of changes in myo-inositol 1-phosphate after acute alcohol administration and the excellent negative correlation between blood alcohol levels and changes in myo-inositol 1-phosphate, alcohol-induced alterations in myo-inositol 1-phosphate appear to be the direct effect of alcohol per se and may participate in the acute pharmacological effects of the drug.

Animals↗
PubMed1975

Function of the male sex organs in heroin and methadone users.

The function of the secondary sex organs was found to be markedly impaired in 29 participants in a methadone maintenance program. The ejaculate volume and seminal vesicular and prostatic secretions were reduced by over 50 per cent in methadone clients, as compared to 16 heroin addicts and 43 narcotic-free controls. Serum testosterone levels were also approximately 43 per cent lower in methadone clients than in controls or heroin users. Although the sperm count of methadone clients was more than twice the control levels, reflecting a lack of sperm dilution by secondary-sex-organ secretions, the sperm motility of these subjects was markedly lower than normal. On all measures of secondary-sex-organ and testicular function, heroin addicts appeared to fall between the methadone and control subjects, but, with the exception of sperm motility, the deviation from control values did not reach statisitcal significance.

Adult↗