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Biomedical subjects

J Guggenheimer

Publications and source records attributed to J Guggenheimer.

At least 37 records · Page 2Linked to original sources
PubMed1977

Clinicopathologic effects of cancer chemotherapeutic agents on human buccal mucosa.

Specimens of buccal mucosa obtained at autopsy from 216 patients were examined for histopathologic alterations. Atrophic oral epithelium was found in thirty cases. A retrospective study of the hospital records revealed that thirteen of these latter patients had been on a cancer chemotherapeutic regimen prior to death. There was a significantly higher incidence of atrophy in the chemotherapy group (p less than 0.001) than in control patients. These findings, as well as the expected inherent susceptibility of rapidly replicating oral epithelial cells to metabolic inhibitors, suggest a causal relationship between oral atrophy and the administration of cancer chemotherapeutic agents. This atrophy may therefore represent a preliminary stage of mucosal alteration that ultimately progresses to the clinical sequelae of stomatitis and oral ulcerations frequently encountered during cancer chemotherapy. Some alternative mechanisms are also discussed.

Adult↗
PubMed1975

Anticipation of dental anomalies induced by radiation therapy.

Therapeutic irradiation of the head and neck of children up to the age of 16 years can cause malformation and developmental arrest of the permanent teeth. Dental anomalies occurring after irradiation of the palatal tumor in an 8-year-old are described and compared with a normal 8-year-old's developmental sequence to demonstrate that the immature, noncalcified dental structures are most susceptible to radiation injury. The stage of dental development at the time of therapy may be precisely determined by a routine oral radiographic survey, which provides a reliable estimate of the deformation that may be anticipated following radiotherapy.

Child↗
PubMed1975

Oral ulcerations associated with indomethacin therapy: report of three cases.

Oral ulcers developed in three edentulous patients who were receiving indomethacin (Indocin) therapy for rheumatoid arthritis. The lesions healed after reduction or discontinuation of the medication. These ulcers are attributed to the combined effects of the indomethacin and the dentures on the oral tissues. In older patient populations, drug-induced oral lesions must be ruled out before a dental prosthesis malfunction is implicated.

Aged↗
PubMedDate not supplied

Herpes simplex virus type 1 replication in a gingival cell line.

Propagation of herpes simplex virus type 1 (HSV-1) in gingival cells is advantageous since these cells are more definitive than HeLa cells in demonstrating viral-induced cytopathic effects and are easily and economically maintained in the laboratory. They also provide a potential medium for studying oral tissue reactions to HSV-1 infection. HSV-1-induced cytopathic effects are clearly characterized following inoculation with virus from standard laboratory cultures and human infections.

Cell Line↗