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Biomedical subjects

J Guardia

Publications and source records attributed to J Guardia.

At least 253 records · Page 14Linked to original sources
PubMed1976

The evolution of alpha heavy chain disease.

Two patients with alpha heavy chain disease are described. In the first patient, treatment with cyclophosphamide, prednisone and doxycycline was associated with a 28 month-long remission and the disappearance of the paraprotein and lymphoplasmocytic infiltration of the intestine. Shortly afterwards, a retroperitoneal immunoblastic lymphoma was found associated with an immunoglobulin G-kappa-paraproteinemia, and gamma heavy and kappa-light chains in the urine; the intestinal biopsy specimen was normal. In the other patient, the alpha chain only appeared two years after the malabsorption syndrome. The fact that in the first, apparently cured patient, a tumor of different anatomic site and secretory capacity appeared, suggests the existence of a B-cell neoplasia of different clone from that which gave rise tothe original disease. In the second patient, it is probable that only the increase in the mass of neoplastic cells led to the detection of the protein abnormality, or alternatively the antigenic-oncogenic stimulus led to the abnormal secretion only after two years.

Adult↗
PubMed1976

Malignant lymphoma with plasmacytoid differentiation and polyclonal gammopathy.

Two patients are presented with lymphadenopathy, hepatosplenomegaly and infiltration of the bone marrow with plasmocytoid cells in whom an important heterogeneous hyperimmunoglobulinemia was detected (3.18 and 5.85 g/100/ml). Autopsy showed widespread poorly differentiated lymphocytic lymphoma with plasmocytoid differentiation in the first case and a well differentiated lymphocytic lymphoma with plasmocytoid differentiation involving lymph nodes, marrow, spleen, liver and kidney in the second case. High concentrations of IgM and IgG were detected in lymph node and spleen homogenates from this case. After splenectomy and cyclophosphamide the immunoglobulins decreased. It is suggested that both cases had a malignant lymphoma with plasmocytoid differentiation and polyclonal gammopathy.

Aged↗
PubMed1975

[Chronic glomerulonephritis with Hb antigen].

The authors report nine cases of chronic glomerulonephritis with positive hepatitis B antigen (AgHB) (8 cases) and positive anti-AgHb (1 case). Five patients had membranous glomerulonephritis. The sub-type was ad in 6 cases and ay in 2. In 3 members of two families of patients, AgHB was positive with the same sub-type as the subject studied. In 5 cases, liver biopsy showed signs of chronic hepatitis. According to the authors, a positive AgHB in glomerulonephritis is often associated with clinically latent chronic hepatitis.

Adolescent↗
PubMed1975

Pericarditis, pleural effusion, and pneumonitis with transient mitochondrial antibodies.

Four women with fever, arthromyalgias, pericarditis, pleural effusion, high erythrocyte sedimentation rates, and lymphopenia had mitochondrial antibodies in the serum in the absence of antinuclear antibody. Their illness lasted 5-12 weeks and the antibody test results became negative on remission. Absence of specific bacteriological findings, normal antistreptolysin O titres, resistance to antibiotics, and good response to steroids suggested that these cases represented a milder and less persistent form of the syndrome resembling systemic lupus erythematosus described by German authors.

Adult↗
PubMed1975

Change of hepatitis B surface antigen in patients with hepatitis during a five-year period.

Between January 1970 and December 1974, 122 cases of acute type B hepatitis were subtyped; 66 (54%) were of the ad type and 56 (46%) were of the ay type. "Cluster" cases (from a dialysis unit) were not considered. During the first period, subtype ad predominated, whereas in the second year there was a clear predominance of the ay subtype; the difference was statistically significant (P less than 0.02). In yearly periods the differences were significant between the years 1970 and 1974 (P less than 0.05), 1972 and 1974 (P less than 0.05), and 1972 and 1973 (P less than 0.05). If only patients without parenteral exposure are considered, there was clearly a shift between 1970-1972 and 1973-1974 in favor of the ay subtype (P less than 0.01). Since epidemiological factors such as injections and transfusions seem not to be responsible, it is suggested that a change of virus strain may be responsible for the different distribution of subtypes of hepatitis B surface antigen in the last year.

Cell Membrane↗