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Biomedical subjects

J Guardia

Publications and source records attributed to J Guardia.

At least 217 records · Page 12Linked to original sources
PubMed1979

[The antigenic e system in carriers of the surface antigen of viral hepatitis B (author's transl)].

In 1972, Magnius and Espmark on confronting different sera containing the surface antigen of hepatitis B with each other, demonstrated a new antigenic item which they called e. In later works the presence of this new antigenic specificity was associated with a greater rate of incidence of chronic hepatic lesion and a greater contagiousness of B virus. In the present study the e system was determined in a group of HBsAG positive blood donors and in a group of patients carrying HBeAG who had been admitted to the hospital for different reasons. The results showed an elevated rate of anti-e antibodies in the asymptomatic donors, and this could be correlated with clinical and biochemical indemnity of the liver function. HBsAg carriers mainly presented renal insufficiency or hematologic disorders, probably related to a deficient immune response. Determination of the e system shows its usefulness in enabling HBsAg positive carriers to be classified according to whether they present or not present hepatic lesion. The presence of HBeAg could be correlated with hepatic lesion, while HBeAc seems to determine some type of protection on those patients who have it in their sera.

Epitopes↗
PubMed1979

[Granulomatous hepatitis. Etiologic study of 107 cases (author's transl)].

An etiologic study was made of 107 cases of granulomatous hepatitis which were observed in a Department of Internal Medicine between January, 1971 and December, 1977 (excluding the hepatobiliary diseases). The most common etiology was tuberculosis (30 cases, 28 percent) followed by sarcoidosis (19 cases, 17.7 percent), Mediterranean exanthematous fever (13 cases, 12.1 percent), brucellosis (8 cases, 7.4 percent) typhoid fever (7 cases, 6.5 percent) and the idiopathic forms (8 cases, 7.4 percent). A lower rate of incidence was among Hodgkin's disease, toxoplasmosis, adenocarcinomas, leprosy, and those of unknown etiology, classified in this way because the study and follow-up of the patients could not be completed. There were, moreover, individual cases caused by mononucleosis, BCG reaction, hypogammaglobulinemia, celiac disease, and temporal arteritis. From a clinical point of view 50 percent of the patients had hepatomegaly and moderate disturbance of the liver enzymes. The most important enzymatic increases were detected in the cases caused by brucellosis; in the cases which were secondary to sarcoidosis the liver enzymes were normal. A comparison is established between the etiologic incidence of the present series and of others published in the literature. The causes and diagnostic problems of this type of lesion are discussed.

Agammaglobulinemia↗
PubMed1979

[Clinical study of gastric lymphomas and pseudolymphomas (author's transl)].

The differentiation between gastric lymphomas and pseudolymphomas represents a clinical, surgical, and pathologic problem affecting both prognosis and therapy. Twenty patients were diagnosed for gastric lymphomas or gastric pseudolymphomas. Only those in stages IE or IIE were included in the first group (13 patients). Pseudolymphomas were diagnosed in seven patients on the basis of histopathologic criteria; all seven had peptic ulcers. Survival among the 13 patients diagnosed for lymphomas was low; six of them died within the first year. The seven cases diagnosed as pseudolymphoma progressed favorably over periods between 2 months and 5 years. The histologic parameters on which the differentiation of the two conditions was based included: a) cell type; b) distribution and limits of infiltration; c) presence of peptic ulcers in pseudolymphomas; and c) characteristics of the regional lymph nodes. The various possible mechanisms of pseudolymphomatous reaction are discussed. It is suggested that the relatively good prognosis reported in some series of gastric lymphomas may be due to the inclusion of pseudolymphomas. There is obvious justification for distinguishing between this two conditions.

Adult↗
PubMed1979

Early pleural effusion in histiocytosis X.

Two cases of histiocytosis X, one of the disseminated form and the other localized to the lung, are reported, in which pleural effusion, probably due to pleural involvement as assessed by biopsy, was one of the initial manifestations of the disease.

Diagnosis, Differential↗
PubMed1979

[Clinical course characteristics of polymyalgia arteritica. Study of 16 cases].

Clinical and biological characteristics are studied in 16 patients with polymyalgia arteritica. 12 of them were diagnosed by biopsy of the temporal artery and the other 4 because they presented clinical, biological data and a high response to corticosteroids. There were no differences according to sex. Most patients (75%) had symptoms since 1-6 months, headache being the most common (75%). Fever (56%), polymyalgia (50%), weight loss (37%), intermittent claudication, loss of vision and arthritis (12%) were the symptoms seen in these patients. ERS was high in all cases, hemoglobin was less than 8 g/100 ml in 8 cases and an increase of alfa-2-globuline was found in 8 patients. Temporal artery palpation was abnormal in 11 patients. Two of 5 patients who presented a normal arterial palpation had a positive biopsy. All patients received 6-metil-prednisolone. 3 are well after 3, 4 and 6 months therapy. 8 are also well but receiving small doses of steroids as treatment.

Aged↗
PubMed1978

[Granulomatous hepatitis: aetiological study of 107 cases (author's transl)].

In this series, the commonest aetiology was tuberculosis (30 cases, 28%), followed by sarcoidosis (18 cases, 17,7%), mediterranean fever (Olmer's disease) (13 cases, 12,1%), brucellosis (8 cases, 7,4%), typhoid fever (7 cases, 6,6%) and idiopathic forms (8 cases, 7,4%). These were followed by Hodgkin's disease, toxoplasmosis, adenosarcoma, and leprosy. Finally, there were single cases due to infectious mononucleosis, B.C.G. reaction, hypogammaglobulinaemia, coeliac disease and temporal arteritis. Half of the patients had hepatomegaly and an increase, in general moderate, in hepatic enzymes (transaminases, alkaline phosphatase). The highest enzyme levels were seen in cases of brucellosis, hepatic enzymes being normal in patients with sarcoidosis.

Alanine Transaminase↗