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Biomedical subjects

J Guardia

Publications and source records attributed to J Guardia.

At least 181 records · Page 10Linked to original sources
PubMed1983

Multicentric giant follicular lymph node hyperplasia. Favorable response to radiotherapy.

Angiofollicular lymph node hyperplasia is a disease of unknown etiology in which two distinct histologic forms are recognized: the hyalin vascular and the plasma-cell types. Up to the current time only a few multicentric cases have been described. The authors describe an unusual case of the multicentric type, which furthermore showed an excellent response to low dosis radiotherapy. Complete, lasting remission was induced and the patient became asymptomatic.

Aged↗
PubMed1982

Periodic meningitis and familial Mediterranean fever.

A 33-year-old man had had, since he was 20 years old, recurrent attacks of fever, rash, and aseptic lymphocytic meningitis. A nephrotic syndrome developed that was found, on renal biopsy, to be due to amyloid deposit. After colchicine therapy, no further recurrence of fever and meningitis was observed. These findings suggest that aseptic periodic meningitis (Mollaret's syndrome) should be considered as an unusual manifestation of familial Mediterranean fever.

Adult↗
PubMed1981

[Transitory IgM monoclonal gammopathy associated with brucellosis and tuberculosis (author's transl)].

Two cases of transitory IgM monoclonal gammopathy associated with infectious disease are presented. One patient was a 29 year-old woman with acute brucellosis; electrophoresis showed a homogeneous spike of slow gamma mobility constituted of IgM lambda. The second case was a 52 year-old male with milliary tuberculosis, in whom a homogenous spike of rapid gamma mobility constituted of IgM kappa was found. The monoclonal component disappeared in both cases after treatment of the infections; at 2 and 21/2 months respectively. The fact that the association of transitory IgM paraprotein and infection is not common, especially with brucellosis, is commented upon and a direct relationship between the infection and the monoclonal component is suggested.

Adult↗
PubMed1981

[Systemic lupus erythematosus with late clinical onset (author's transl)].

This report concerns a retrospective study of 14 patients with systemic lupus erythematosus (SLE) of onset after age 50, the clinical, evolutive, and therapeutic aspects having been evaluated. Eleven patients were female and three were male. Mean age of onset of symptoms was 60 years. Most frequently observed symptoms were arthralgias and/or arthritis, followed by pleurisy and/or pericarditis. A high incidence of liver involvement was noted. All the patients were treated with 6-methyl prednisolone. Four patients died, two as a consequence of chronic renal failure, and two from complications likely related to corticosteroid therapy. It is concluded that SLE of late onset has certain clinical and therapeutic features that distinguish it from that of earlier onset.

Age Factors↗
PubMed1981

[Histologic evolution of acute alcoholic hepatitis].

Although acute alcoholic hepatitis is a frequent disease with distinct histologic diagnosis, the prognostic factors of its evolution are largely unknown. The present report analyzes the data of 18 patients with acute alcoholic liver disease submitted to two liver biopsies with a mean interval of 35 months. The results demonstrate a favorable histologic evolution in six of seven patients that abandoned alcohol ingestion, and an evolution to chronic liver disease in the remaining case. Out of six patients with continuous alcohol ingestion the evolution was unfavorable in five, while one case evolved to healing. Centrilobular fibrosis disappeared in the six cases that discontinued alcohol ingestion and who had favorable evolution, and it persisted in four of the six patients that continued drinking. The results suggest that centrilobular fibrosis is not always an unfavorable prognostic marker, and that the evolution of acute alcoholic hepatitis is not exclusively dependent on the continuation of alcohol abuse.

Acute Disease↗