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J Groner

Publications and source records attributed to J Groner.

4 recordsLinked to original sources

Smoking behaviors of women whose children attend an urban pediatric primary care clinic.

OBJECTIVE: To characterize smoking behaviors of caregivers whose children attend a large urban pediatric primary care center. DESIGN: Descriptive survey. Women (n = 479) classified as smokers completed a questionnaire including demographics, smoking habits, measures of addiction, social reinforcers for smoking, attitudes and knowledge, other health and safety habits, and the pediatrician's role in smoking cessation counseling. RESULTS: Of 1421 women surveyed, 36.6% (517) were classified as daily smokers. Four hundred and seventy-nine (93%) were enrolled in the study. Thirty-eight (7%) refused or were ineligible. Smokers differed significantly from non-smokers, with smokers more likely to have lower incomes (p<.03), lower educational attainment (p<.001), and were more likely to be white than non-smokers (p<.001). The average smoker smoked 14 cigarettes per day for 10 years. Half of the subjects had not considered quitting smoking in the near future. The majority of subjects (66%) lived with at least one other smoker, and reported that more than half of their friends smoked. Most (79%) participants agreed that pediatricians should give smoking cessation advice to parents of their patients. However, only 19% recalled being counseled to quit, and 55% recalled their child's doctor discussing the danger of environmental tobacco smoke. CONCLUSION: The pediatric visit is an excellent opportunity for identifying women who smoke. Efforts to assist women with smoking cessation in similar settings will need to take into account their poverty and the high degree of social support for their continued smoking.

Adult↗

Genetic and molecular analyses of lymphocyte-defined HLA-D region specificities.

Determinants encoded in the HLA-D region have been studied with both cellular (PLT) and molecular (SDS-IEF) methods. When the PLT response against a lymphoblastoid cell line was analyzed by limiting dilution culture and determination of the reactivity of individual cultures against a panel of loss mutants of the initial stimulating LCL, a large fraction of the cultures showed the same pattern, apparently recognizing a determinant associated with DR. In two-dimensional gel analysis of several DR4-positive HLA-D region homozygous cells, the IEF pattern of the DR beta chain correlated with the Dw specificity expressed by the cell. These two pieces of evidence suggest that, although many determinants may contribute to reactivity in mixed leucocyte culture or PLT, an immunodominant determinant associated with the DR beta chain may be the most important single factor in the assignment of Dw specificity.

Epitopes↗