Search PubMed⌕ Search

Biomedical subjects

J Greif

Publications and source records attributed to J Greif.

67 records · Page 4Linked to original sources
PubMed1984

[Therapy of the hypertensive crisis with urapidil. Various effects on patients with or without coronary disease].

The effect of urapidil on various hemodynamic and echocardiographic parameters has been investigated in 36 patients with hypertensive emergencies (14 patients with coronary artery disease, 22 patients without coronary artery disease). During treatment with urapidil, blood pressure decreased in both groups by 35%, the heart rate decreased slightly (3-8%). The mean pulmonary artery pressure decreased by 45% (coronary patients) respectively 36% (non-coronary patients), the pulmonary capillary wedge pressure by 59% (coronary patients) resp. 48% (non-coronary patients). Cardiac output increased in both groups by about 20%. In the echocardiogram, both groups showed decreases in the diameters of left atrium and left ventricle, and an increase in the fractional shortening of the left ventricle. Patients with coronary artery disease required less urapidil than non-coronary patients.

Acute Disease↗
PubMed1984

Bronchodilating effect of cromolyn sodium in asthmatic patients at rest and following exercise.

A total of 27 patients with extrinsic asthma participated in a double-blind trial comparing the effect of nebulized cromolyn sodium and placebo on pulmonary function both at rest and after exercise. At rest, cromolyn sodium improved lung function. Compared to baseline, peak expiratory flow rate (PEFR) increased by 20.5 + 11.8% and 8.8 +/- 16.0% after cromolyn sodium and placebo, respectively. The difference is statistically significant (p less than 0.01). Following drug administration immediately after completing six minutes of free running exercise, PEFR increased by 2.3 +/- 8.2% with cromolyn sodium, whereas a fall of 19.8 +/- 12.5% was observed with placebo. This difference is significant at the p less than 0.01 level. The results show that cromolyn sodium is capable of producing immediate bronchodilatation in asthmatic subjects, both at rest and following induction of bronchoconstriction by exercise. These findings suggest that cromolyn sodium may have mechanisms of action other than stabilizing mast cell degranulation.

Adolescent↗
PubMed1983

Primary actinomycotic empyema.

We have presented a rare case of massive primary actinomycotic empyema, which resolved after combined cefazolin therapy and continuous pleural drainage. Poor dental hygiene and heavy smoking are proposed as predisposing factors.

Actinomycosis↗
PubMed1980

Prazosin protects vascular alpha-adrenoceptors against irreversible blockade by phenoxybenzamine.

The interaction of prazosin with the vascular alpha-adrenoceptor was studied in isolated vessel preparations by means of receptor protection experiments. Prazosin was compared to phentolamine. Prazosin, like phentolamine protected the receptor against irreversible blockade by phenoxybenzamine. It is concluded that prazosin acts by a direct occupancy block of the vascular alpha-receptor.

Animals↗
PubMed1976

Disodium cromoglycate in the treatment of seasonal and perennial rhinitis.

The efficacy of a 2% solution of disodium cromoglycate was evaluated in 15 patients suffering from seasonal rhinitis and 24 patients suffering from perennial rhinitis. DSCG proved to be highly effective in the seasonal group where pollen was demonstrated to be the cause but gave relief only in some atopic patients of the perennial group.

Adolescent↗
PubMedDate not supplied

Pulmonary changes in angioimmunoblastic lymphadenopathy as demonstrated by computerized tomography.

A case of angioimmunoblastic lymphadenopathy with pulmonary involvement is presented. The radiographic and computerized tomographic findings included multiple opacities, predominantly basal, of variable size. Associated pleural opacification was verified on both the chest roentgenogram and the computerized tomographic (CT) examination. The entity may mimic many more common clinical disease states and final diagnosis can only be established histologically.

Aged↗
PubMedDate not supplied

Percutaneous core needle biopsy vs. fine needle aspiration in diagnosing benign lung lesions.

OBJECTIVE: To determine the diagnostic value of percutaneous core needle biopsy (PCNB) in comparison with fine needle aspiration (FNA) in patients with benign pulmonary lesions. STUDY DESIGN: A retrospective review was undertaken of computed tomography-guided PCNBs and FNAs performed between 1988 and 1997. Both FNA and PCNB biopsies were carried out sequentially at the same visit in every patient. RESULTS: A specific benign diagnosis was made in 10/60 cases (16.7%) by FNA and in 49/60 (81.7%) by PCNB. PCNB findings resulted in significant modification of the diagnosis established by FNA. The only significant complication encountered was pneumothorax, at a rate of 11.7%, which is compatible with that reported in the literature for complications induced by FNA alone. CONCLUSION: Radiologically guided PCNB is a safe procedure, can provide sufficient histologic material for a specific diagnosis of peripheral lung disease and can avoid more-invasive surgical procedures in many cases. Our experience demonstrated that the histologic analysis provided by PCNB can greatly increase the diagnostic accuracy in benign pulmonary diseases as compared with the yield of FNA.

Adult↗