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Biomedical subjects

J Gras

Publications and source records attributed to J Gras.

At least 91 records · Page 5Linked to original sources
PubMed1965

Immunoelectrophoresis reveals collagen solubility in human serum.

A fraction of humanserum proteins which contains hydroxyproline migrates, on electrophoresis, with the alpha(2)-beta-globulins. Immunoelectrophoresis with rabbit antiserum to soluble human collagen reveals an immunologically collagen-like protein in the human serum.

Animals↗
PubMedDate not supplied

Temporal relationship between primary injection and cyclophosphamide administration necessary for the inhibition of the priming for a secondary response.

Using the mouse PFC anti-SRBC response, the temporal relationship between primary antigen dose and cyclophosphamide (CP) administration necessary for the inhibition of priming for the secondary IgG response was studied. The administration of CP 1 h after the primary or secondary antigen injection inhibits the responses in both cases. The administration of CP 1 h after the primary antigen injection does not inhibit priming for the secondary response; this priming is inhibited if CP is administered at 12 h or more, and the maximal degree of inhibition is induced when CP is administered 7 or 9 days after the primary antigen injection. Therefore, the proliferation stage of mature B cells to IgM secretion is not necessary for this priming. It is suggested that the switch from IgM to IgG takes place in a proliferative stage of B-cell precursors in presence of the antigen.

Animals↗
PubMedDate not supplied

Effect of cyclophosphamide on specific IgM and IgG responses and recovery during the various stages of persistent immunization in the Brucella-rabbit model.

The effect of one or several doses of cyclophosphamide (CP) administered to rabbits persistently immunized with Brucella abortus was investigated. The goal was to halt the response at different stages of the hyperimmunization process and to study the kinetics and IgM- or IgG-nature of the response following CP discontinuation. It was observed that CP halted the response; and once the drug had been discontinued, the post-CP response reached titres much higher than those of either the controls or the animals before CP administration (rebound effect). On the other hand, it was noticed that the post-CP response was mainly IgM when the drug was given in the early stages of hyperimmunization, and IgG when the drug was given at later stages.

Animals↗
PubMedDate not supplied

The paediatric liver transplantation program at the Université catholique de Louvain.

The Paediatric Liver Transplant Program at Saint-Luc University Clinics constitutes a substantial single centre experience, including 667 transplantations performed between March 1984 and April 2003, and the history of this program reflects the tremendous progress in this field since twenty years. Liver transplantation in children constitutes a considerable undertaking and its results depend on multiple, intermingled risk factors. An analysis of the respective impact of several surgical and immunological parameters on patient/graft outcome and allograft rejection after paediatric liver transplantation showed a significant learning curve effect as well as the respective impact of pre-transplant diagnosis on survival and of primary immunosuppression on the rejection incidence. The introduction of living related liver transplantation in 1993 not only permitted to provide access to liver replacement in as many as 74% more candidate recipients, but also resulted in better graft survival and reduced retransplantation rate. The results of a recent pilot study suggest that steroid avoidance is not harmful, and could even be beneficial for paediatric liver recipients, particularly regarding growth, and that combining tacrolimus with basiliximab (anti-CD25 chimeric monoclonal antibody) for steroid substitution appears to constitute a safe alternative in this context. The long-term issues represent the main future challenges in the field, including the possibility of a full rehabilitation through immunosuppression withdrawal and tolerance induction, the development of adolescence transplant medicine, and the risk of early atherogenesis in the adulthood.

Adolescent↗