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Biomedical subjects

J Graham

Publications and source records attributed to J Graham.

At least 379 records · Page 21Linked to original sources
PubMed1981

Lymphocyte transformation to specific antigens associated with Crohn's disease.

Specific lymphocyte transformation to three micro-organisms that have been implicated in Crohn's disease was performed. These were Pseudomonas maltophilia, Mycobacterium kansasii and Rotavirus. No significant differences were observed for any of the antigens tested. Simultaneous testing of nonspecific stimulation by PHA also showed no difference between patients and controls. These results do not support an aetiological role for these organisms mediated by a purely cellular mechanism.

Adult↗
PubMed1981

Cerebellar calcification.

Previous autopsy studies have shown that cerebellar calcification is commoner in Queensland than elsewhere. Computed cranial tomography, which is more sensitive than skull radiography, has confirmed that cerebellar and basal ganglia calcification occur more commonly in patients examined in Queensland than in North America. Although no distinctive neurological syndrome could be demonstrated, the affected patients showed a high incidence of hypertension, hyperuricaemia and raised serum creatinine levels. There is evidence that cerebellar calcification is a marker of previous lead intoxication. Common occurrence of renal impairment in these patients may be due to associated lead nephropathy. Subclinical lead exposure is associated with hyperuricaemia.

Adult↗
PubMed1980

Urinary bladder metastases from breast carcinoma.

Four patients with primary carcinoma of the breast metastatic to the urinary bladder are described. Hematuria was present in 3 of the 4 patients. Two of the 4 women had received steroidal drugs which may have a role in the development of this unusual metastasis. This complication developed no sooner than 32 months after diagnosis of malignant breast disease and occurred shortly before death in 2 of the patients. Bladder metastasis in women with a history of breast carcinoma may be more prevalent than has previously been suspected.

Aged↗
PubMed1980

A light microscopic and electron microscopic study of the superficial layers of the superior colliculus of the tree shrew (Tupaia glis).

Histochemical, Golgi, and electron microscopic methods were used to study the superficial layers of the superior colliculus of the tree shrew. Following horseradish peroxidase injections in the dorsal lateral ceniculate nucleus (LGd) and the pulvinar (Pul), retrogradely labeled somata were found in the upper two-thirds and the lower third of the stratum griseum superficiale (SGS), respectively, as has been described by Albano et al. ('79). In tissue prepared with Golgi methods, somata, similar in locatin and shape to those projecting to the LGd, had narrow, vertically oriented dendritic arbors, which were confined to the upper two-thirds of th SGS. Cells located in the lower third of the SGS had larger somata, similar to those projecting to the Pul, and wider dendritic arbors, which were confirmed to the lower two-thirds of the SGS. Electron microscopic comparison of the number of degenerating terminals following enucleation and striate cortex lesion indicated that within the SGS terminals from the retina overwhelmingly outnumbered those from the cortex. In both types of material, degenerating terminals were observed throughtout the SGS. However, the majority of te degenerating striate terminals were found in the lower SGS. Thus, cells that project to the LGd and those that project to the Pul differ not only with respect to location, size, and dendritic morphology, but also with respect to the proportion of retinal and straite afferents which terminate in the region of their dendritic trees.

Animals↗
PubMed1980

Laser therapy of rheumatoid arthritis.

Thirty people with classical or definite rheumatoid arthritis received laser exposure to a Q-switch neodymium laser that operated at 1.06 micrometer with an output of 15 joules/cm2 for 30 nsec. One hand was lased at the proximal interphalangeal (PIP) and metacarpal phalangeal (MCP) joints, whereas the other hand was sham lased. The patient, physician, and occupational therapy evaluators did not know which hand was being lased. Twenty-one patients noted improvement of both their MCP and PIP joints of both hands during laser therapy. Twenty-seven noted improvement of their PIP joints and 26 noted improvement of the MCP joints during therapy. Heat, erythema, pain, swelling, and tenderness all improved with time in both hands, but the lased hand had more significant improvement in erythema and pain. There was also significant improvement in grasp and tip pressure on the lased side. The level of circulating immune complexes as measured by platelet aggregation decreased during lasing. The improvement may be related to laser exposure. The exact role that laser radiation has upon rheumatoid arthritis and its mechanism of action remain to be elucidated.

Adult↗
PubMed1980

Cortical deafness--a case report and review of the literature.

A 48-year-old woman with triple cardiac valve prostheses became completely deaf after bitemporal embolism. The lesions were demonstrated radiologically and neurophysiological investigation confirmed intact peripheral and brainstem pathways. Experimental studies of the auditory pathways are briefly reviewed. Reported cases of cortical deafness are discussed and the rarity of the condition emphasised.

Auditory Cortex↗
PubMed1980

The presence of lactogen receptors in human chorion laeve.

Lactogen receptors have been identified in human chorion laeve and possibly placenta but not other periplacental tissues. The receptors show the same hormonal specificity, and similar binding parameters (affinity 0.47 x 10(9) l/m, capacity 175 fmol3/mg) to lactogen receptors in mammary gland and liver. The presence of these receptors, suggests they may play a role in mediating an action(s) of amniotic fluid prolactn in chorion laeve, such as osmoregulation.

Chorion↗
PubMed1980

Chronic paroxysmal hemicrania (CPH). The clinical manifestations. A review.

Eight definite and 10 possible cases of CPH are known to the authors. Decisive diagnostic features in the differential diagnosis versus ordinary cluster headache (Horton's headache) seem to be: the presence of headache every day, a high maximum daily attack frequency (greater than or equal to attacks/24 hours) and an absolute indomethacin effect. There is increasing evidence for a female preponderance in CPH. It emerges from this study that there frequently (or invariably?) is a pre-CPH stage with atypical attack pattern, usually lasting several years. Pregnancy seems to have a rather clear ameliorating effect on attack frequency and severity. In other patients, the very onset of headache is immediately after delivery. The importance of recognizing this special headache from a clinical point of view is clear since this disabling disorder can be completely abolished by drug therapy.

Age Factors↗
PubMed1980

Automated chromosome analysis using the Magiscan Image Analyser.

An automated chromosome analysis system is being developed based on a commercially available image analyzer. At its present stage of development, the system will perform a complete analysis of well-spread, homogeneously stained metaphases. The system incorporates a metaphase finder to detect cells of potentially good quality. Chromosomes in a selected cell are segmented by their grey level using a locally determined threshold. An axis and a centromere are automatically assigned to each chromosome, and a "flexible" lookup table is used to classify the chromosomes into nine groups based on measurements of length and centromeric index. A grey-level karyogram can be displayed. Operator intervention is possible, thus permitting resolution of overlaps, correction of erroneous centromere assignments and modification of the karyogram. Analysis time is about two minutes per cell.

Animals↗