1785 newborns of 37 weeks GA or more, were studied during a 15 months period at the Port-Royal Maternity Hospital. This study suggests that cerebral abnormalities during the neonatal period in fullterm neonates are related to deleterious intra partum factors. In 57 newborns, clear cut signs of cerebral birth injury were observed, in 31 newborns only mild and transitory signs were observed. These 88 newborns were compared with 1655 having had a normal neurological examination within the first week of life. We focused particulary on dysfunctional labor patterns, specifically false labor, protracted active phase dilatation, protracted descent or a marked caput succedaneum. When these abnormal patterns are followed by oxytocin infusion and forceps extraction, primiparity appears linked with a high risk of cerebral birth injury. Within cephalic presentations, the occipito-posterior position is carrying the same high risk. The most severe degree of cerebral birth injury has nearly disappeared. However, the main problem of modern obstetrics is one of eradicating brain damage of moderate degree without reaching an excessive incidence of C. section.

Asphyxia Neonatorum↗

PubMedDate not supplied

[Evaluation by poison control centers of minaprine from the modification of tablet dosages].

By 1990, the Clin Midy (SANOFI) laboratory had modified the dose of Cantor tablets: the content of active drug (minaprine) increased (50 to 100 mg). Therefore, acute intoxication by minaprine can be serious, with generalized seizures, resisting the classic treatment. We tried to evaluate the possible consequences of this change of dose for the gravity of suicide attempts. 1091 voluntary acute intoxications have been collected by the national French Poisons Centres data bank, 226 of them by the Poisons center of Marseilles. We have compared, by the chi 2 method, the frequencies of seizure and death, before and after 1990. Results are significant, confirming an increased gravity of these intoxications since the modification of dosage. Then, the laboratory reduced the number of tablets per box. We don't know if this measure will be efficient.

Adolescent↗

PubMedDate not supplied

[Macroscopic examination of the fresh placenta. Statistical analysis of 1,200 cases. Comparison with maternal and neonatal pathology].

We have examined 1,200 placentas in a fresh state and have compared the results of these examinations with maternal pathology on the one hand and the neo-natal pathology on the other hand. It turns out that most abnormalities of pregnancy are associated in a significant way with the pathological findings in the placenta, and that the good or pathological health of the newborn is significantly associated with the normal of pathological character of the placenta. The principal weakness in this method of examination is the absence of information about infection. This is why it seems important to us to carry out smears from the placenta before examining it macroscopically.

Adult↗