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Biomedical subjects

J Gosepath

Publications and source records attributed to J Gosepath.

At least 19 recordsLinked to original sources
PubMed1998

[Paranasal sinus carcinomas with orbital involvement].

Fifteen patients at the University of Mainz were diagnosed as having T3 or T4 carcinomas of the paranasal sinuses that invaded the orbit. Treatment involved surgical resections of tumor with adjacent periorbita but without enucleation in an attempt to preserve vision and/or cosmesis. Survival rates and especially the rate, time and locations of recurrences were investigated. Analysis of the data revealed that preservation of the eye in these cases with advanced sinus carcinomas with orbital tumor involvement did not seem to worsen prognosis. The individual gain in terms of quality of life through the preservation of vision and cosmesis seems to justify the surgical approach used.

Female↗
PubMed1998

[Biology and growth velocity of tumors of the globus jugulotympanicum and glomus caroticum].

BACKGROUND: Paragangliomas (glomus tumors) of the head and neck are rare tumors, arising from the paragangliomatous tissue either of the carotid region or the jugular or the tympanic region. This study was conducted to investigate the possible differences in the tumor biology of these lesions depending on their site of origin. METHODS: Nineteen specimens (10 jugulotympanic and 9 carotid glomus tumors) were investigated by quantitative DNA measurements and immunohistochemical assessment of proliferation markers (PCNA, Ki67), oncogenes (p53, nm23), different cell surface antigenes (CD44 4/5 and 6, CD54, CD106), and bcl 2 as a marker for apoptosis. RESULTS: Depending on the location of the tumors these measurements revealed significant differences in tumor biology with higher proliferation scores and a higher number of aneuploid tumors in those of the carotid region, suggesting a more aggressive behavior compared to those of the jugulotympanic region. CONCLUSIONS: The results also indicate a difference between the two groups in the risk of developing metastases or recurrent disease. They generally help to enhance our understanding of the biology of paragangliomas of the head and neck.

Adolescent↗
PubMed1991

[Treatment results following supraglottic laryngectomy in carcinoma of the oropharynx, base of the tongue and hypopharynx. 1. Indication limits of supraglottic laryngectomy].

The indications are exactly fixed and critically screened in 110 cases of supraglottic laryngectomy. Comparison with more radical surgical methods yields the same results with functional advantages of supraglottic laryngectomy. The limitations of resection are: the foramen coecum at the base of tongue, the arytenoids and the vocal cord at the entrance of the larynx, the piriform recessus in cases of extension to the hypopharynx.

Aged↗
PubMed1991

[Treatment results after supraglottic partial resection of the larynx in carcinoma of the laryngeal entrance, the base of the tongue and hypopharynx. 2. Radiotherapy and late results after combined surgical-radiological treatment].

110 Patients were followed-up after supraglottic laryngectomy: The 3-year survival rate was 74%. The overall 5-year survival rate was 49%. For the cases of T3-tumours from these of the entrance of the larynx the 5-year survival rate was about 73%. For the T4-tumours the 5-year survival rate was only about 22%. Better results are not possible at the present even if other kinds of therapy are used.

Cobalt Radioisotopes↗
PubMed1990

[Long-term study following frontolateral partial larynx resection].

Between 1972 and 1981 frontolateral laryngectomy was performed in 72 cases of vocal cord cancer. Regular follow-up examinations were performed over a period of at least five and up to 15 years after primary surgery. In 1987, 63 of these patients were still alive. In 68 out of 72 (94.3%), survival time was three years or more. In 34 out of 43 (79%), survival time was five years or more. Leroux-Robert's indication guidelines are confirmed and slightly extended. The functional results and the frequency of recurrence are reviewed.

Adult↗
PubMed1990

[Cysts of the thoracic canal. Apropos of a subclavicular site].

The authors report a case of cystic dilatation of the terminal portion of the thoracic duct which clinically corresponded to a swelling in the root of the left side of the neck. Pathogeny and evolutive mode of this exceptional affection are ill known. Echography and scanography show the cystic nature of the mass. Diagnosis is made by direct puncture which can prove the chylous nature of the content and permits the opacification of the cyst. Lymphography shows the type of junction with the thoracic duct.

Adolescent↗
PubMed1983

[Results of transtemporal vestibular neurectomy in the treatment of Ménière's disease].

From 1972 to 1979 transtemporal neurectomy of the vestibular nerve was performed on 42 patients suffering from therapy-resistant symptoms of ménière's disease. Regular postoperative follow-up for 3 to 10 years after neurectomy showed that all 42 patients had no further attacks of vertigo. Tinnitus was diminished or disappeared in 25 patients; postoperative audiologic controls revealed no changes in 20 patients (48%), and a hearing gain in 3 cases (7%). 19 patients (45%) present with a slowly progredient hearing loss in continuation of the preoperative development. The sensation of pressure in the ear was observed by 19 patients and improved in all of them immediately after the operation, but reappeared in 12 of them (29%) within 6 months postoperatively.

Adult↗
PubMed1983

[Frequent mistakes in corrective rhinoplasty].

The choice of special techniques and a certain flexibility of the surgeon in performing his personal methods, and also the preoperative and intraoperative evaluation of specific characteristics of the nasal structures, are important factors in the prevention of mistakes and complications in rhinoplasty. Typical mistakes in septoplasty and the surgical treatment of the turbinates and the dermal and soft tissue structures are discussed. Septal subluxation, deviations of the nasal tip or postoperative scar formation often result in difficult postoperative corrective problems. Lack of care in the removal of bony or cartilaginous humps can lead to very bad nasal deformations. Precise control of all structures at the end of the operation and eventual final correction or "finishing" will often help to avoid secondary septo-rhinoplasties.

Cartilage↗
PubMed1979

[Otological possibilities of conservation and reconstruction of facial function in operations within the internal auditory canal and the cerebellopontine angle (author's transl)].

Description of the possibilities of operations within the internal auditory canal and the cerebellopontine angle, especially of the removal of acoustic neuromas by transtemporal and translabyrinthine approach. Besides at the total removal of the tumor the operative technique aims at the conservation of the facial nerve and its function. The transtemporal approach is recommended only for the removal of small tumors limited to the internal auditory canal. If the tumor originates from the vestibular nerve, the facial and cochlear nerve can be preserved by this procedure. The translabyrinthine approach implicate the complete unilateral deafness but is available even for the removal of bigger tumors leaving the internal auditory canal in the direction of the cerebello-pontine angle. Sketches and operation slides illustrate details of the operative preparation. Special difficulties occuring in the cerebellopontine angle are demonstrated. Clinical and diagnostic problems in relation to the operation planning are discribed. The cooperation between otosurgeon and neurosurgeon is indispensable

Cerebellopontine Angle↗