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Biomedical subjects

J Gordon

Publications and source records attributed to J Gordon.

At least 541 records · Page 30Linked to original sources
PubMed1972

Chromosomal localization of the structural genes of the polypeptide chain elongation factors.

A survey of the polypeptide chain elongation factors in potentially sexually compatible genera was carried out. Factors from Escherichia coli and Proteus mirabilis were found to be clearly distinguishable by immunochemical and electrophoretic techniques. Mapping of the structural genes of these factors was undertaken by a study of the gene products in genetically defined E. coli-P. mirabilis hybrid diploid strains. It was found that the EF G factor mapped within 5 min of the streptomycin resistance locus, but the EF Ts factor did not map in this region.

Bacterial Proteins↗
PubMed1971

Participation of three cell types in the anti-sheep red blood cell response in vitro. Separation of antigen-reactive cells from the precursors of antibody-forming cells.

Spleen cells of unprimed CBA mice were shown to produce anti-sheep red blood cell antibodies comparable in amount in vivo and in vitro. Under identical culture conditions spleen cells of C57BL mice did not respond. CBA spleen cells, passed through columns of cotton wool (CBAf), were equally inactive in vitro. However combined cultures containing both CBAf and C57BL cells yielded as many or more plaque-forming cells than the same number of unfractionated CBA spleen cells. Analysis of the contribution of each cell population to the synthesis of antibody in the combined cultures has disclosed the participation of three cell types. A thymus-dependent, radiosensitive cell was derived from the CBAf population, while the C57BL was the source of the precursor of the antibody-forming cell and of a radioresistant cell. The latter two were partially separated in a Staput apparatus.

Animals↗
PubMed1971

The mouse intestinal microflora with emphasis on the strict anaerobes.

The various components of the intestinal microflora in the mouse become established according to a definite time sequence; the strict anaerobes are the last groups of bacteria to reach their maximum population levels, 14-16 days after birth. The multiplication of these strict anaerobes in the mouse intestine seems to depend upon the prior multiplication of other bacterial species, and coincides with the ingestion of food other than maternal milk. These two conditioning factors may correspond to the establishment of a suitably reduced Eh potential and to the provision of certain metabolites. Once established, the strict anaerobes constitute by far the largest percentage of the total intestinal microflora; most of them are associated in a viable form with the mucosa. In normal animals they persist at very high levels throughout the life span. However, their populations can be drastically reduced by dietary manipulation of the animal, by administration of vancomycin, or by certain disease processes of the intestine. The strict anaerobic bacteria seem to play an important, and perhaps essential role in the maintenance of the anatomic structures and physiological functions of the intestine. They also seem to hold in check several species of intestinal bacteria, in particular the coliform bacilli.

Age Factors↗
PubMed1971

Intestinal spirochaetosis.

An abnormal condition of the large intestine is described in which the surface epithelium is infested by short spirochaetes. Diagnosis can be made by light microscopy. A review of 14 cases diagnosed by rectal biopsy and 62 cases involving the appendix shows no consistent symptom complex. The possible significance is discussed.

Adult↗