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Biomedical subjects

J Golomb

Publications and source records attributed to J Golomb.

At least 73 records · Page 4Linked to original sources
PubMed1987

Local hyperthermia of the prostate gland for the treatment of benign prostatic hypertrophy and urinary retention. A preliminary report.

The Prostathermer (TM), a system designed to deliver hyperthermic treatment to the prostate gland, was used to treat six patients with benign prostatic hypertrophy and urinary retention. The 99-D model consists of a microwave generator operating at 915 MHz, an applicator with a built-in water cooling system, temperature probes and an IBM PC-XT type computer. The treatment regimen differed from patient to patient in the number of treatments (range 5-10), frequency per week (range 1-2), and average radiofrequency (RF) transmission. Sustained controlled heating of the prostatic tissue up to 39.4 to 45.2 degrees C was carried out for 60 min in each session. Five patients were relieved of their indwelling catheters and at follow-up 6 months after termination of therapy they were well by objective and subjective criteria. No complications were encountered. This is preliminary report of our results of treatment with 47 hyperthermic sessions in six patients.

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PubMed1986

Bilateral metachronous xanthogranulomatous pyelonephritis in end-stage renal failure.

We report a case of bilateral metachronous xanthogranulomatous pyelonephritis (XGP) in a hemodialyzed patient with end-stage renal failure due to bilateral nephrolithiasis. The XGP was initially diagnosed by computed tomographic (CT) scan, and right nephrectomy was performed. The patient remained clinically stable for the next year. Involvement of the contralateral kidney was again confirmed by CT examination. Both kidneys showed histologic changes compatible with XGP. A coexisting nephrogenic adenoma of the bladder has been attributed to chronic urinary tract infection.

Female↗
PubMed1986

Demonstration of antispermatozoal antibodies in varicocele-related infertility with an enzyme-linked immunosorbent assay (ELISA).

To assess the existence of a possible immunologic factor in varicocele-associated infertility, we searched for antispermatozoal antibodies in serum, seminal plasma, and bound to spermatozoa in 32 infertile men with varicocele and 22 infertile patients without palpable varicocele, with the use of an enzyme-linked immunosorbent assay. In addition, we performed morphologic and microbiologic analyses of the semen and urethral smears for isolation of Chlamydia trachomatis. Twenty-nine men from the varicocele group (90.6%) demonstrated antispermatozoal antibodies, compared with only 9 men (40.9%) in the control group. The antibodies in both groups, when present, were mainly serum and seminal plasma immunoglobulins IgA and IgM. A significant quantitative difference between the varicocele and control groups was also observed for serum IgA, seminal plasma IgA and IgM, and sperm-bound IgG, IgA, and IgM. Oligozoospermia and asthenozoospermia were significantly more prevalent in the varicocele men. An asymptomatic genital tract infection with C. trachomatis, Ureaplasma urealyticum, and Escherichia coli was traced in 40.6% of the varicocele men and in 45.5% of the control group. No interaction could be demonstrated between the infection and antispermatozoal antibody formation. These data suggest that an immunologic factor may play a role in varicocele-associated infertility; however, its impact on reproduction has yet to be assessed.

Antibodies↗
PubMed1986

Concentration of ciprofloxacin in human prostatic tissue after oral administration.

Concomitant concentrations of ciprofloxacin in serum, urine, and prostatic tissue were determined in 15 patients after single oral doses of 750 mg. Levels in tissue ranged from 0.6 to 4.18 micrograms/g, and therapeutic concentrations were demonstrable for up to 9 h after administration. The mean ratio of tissue to serum concentration was 0.93 +/- 0.08 (standard error).

Administration, Oral↗
PubMed1986

Recurrent bladder perforation in chronic irradiation cystitis.

Chronic irradiation cystitis may cause fibrosis and weakening of the detrusor, with greater susceptibility of the bladder wall to endoscopic trauma. We lately treated a patient with chronic irradiation cystitis who sustained recurrent bladder perforation, one after electrohydraulic lithotripsy and the other--following cystoscopy. The first event was handled surgically and the second one in a conservative approach. We hereby report on the case and comment on the etiology.

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PubMed1985

Strangulated prolapse of the urethra in the elderly female.

Circular prolapse of the urethral mucosa in the elderly female is rarely reported in the literature, but is a common clinical entity. During the years 1972-1983 thirteen women with urethral prolapse were operated upon in our department, in all of whom differentiation of the benign lesion from malignancy could not be done on clinical grounds only. The following survey is meant to draw attention to the entity and its clinical implications.

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PubMed1984

[Sarcomatoid carcinoma of the kidney].

Sarcomatoid renal carcinoma is an uncommon renal malignancy with an aggressive biological behaviour and very poor survival rate. We treated lately 4 patients, three of which died shortly after the operation. The case reports are presented and the histology and the clinical implications are discussed.

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