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Biomedical subjects

J Goldstein

Publications and source records attributed to J Goldstein.

At least 361 records · Page 20Linked to original sources
PubMed1975

Evaluation of two kinds of smallpox vaccine: CVI-78 and calf lymph vaccine. II. Clinical and serologic observations of response to revaccination with calf lymph vaccine.

Revaccination with standard calf lymph vaccine was performed on 26 children who had received a primary vaccination with an attenuated smallpox vaccine, CVI-78, and 22 children who had received primary vaccination with standard calf lymph. Revaccination resulted in a vesicular reaction in 96 percent of those who had been vaccinated previously with CVI-78 and 73 percent of those vaccinated previously with standard calf lymph. All children had a positive hemagglutination-inhibition (HI) antibody titer either after primary vaccination or revaccination. Only 65 percent of those initially vaccinated with CVI-78 vaccine had positive neutralizing antibodies after revaccination. All children who received primary vaccination with standard calf lymph had postrevaccination neutralizing antibodies. The children who had neither a dermal nor a serologic response after primary vaccination responded as primary vaccinees on challenge with standard calf lymph.

Animals↗
PubMed1975

Head-turning induced by electrical stimulation of the caudate nucleus and its antagonism by anti-parkinson drugs.

Intermittent high-frequency electrical stimulation of the caudate nucleus induces contralateralhead-turning in rats. The anti-Parkinson drugs, L-dopa, amantadine and apomorphine, raise the threshold for or completely inhibit head-turning. There was a high correlation between the predicted clinical potency and these drugs based on inhibition of head-turning and their respective clinical anti-Parkinson potency. The centrally acting anticholinergic drugs also antagonized head-turning but there was not a good correlation between the predicted and acutal anti-Parkinson doses used in man. In order to determine if these drugs blocked head-turning by acting on the caudate nucleus, a combination cannula and stimulating electrode was used to administer drugs directly into the same area of the caudate nucleus being stimulated electrically. Dopamine, amantadine and apomorphine each antagonized head-turning when infused into the same site, at doses which did not produce concurrent overt sterotyped behavior. Time- and dose-response data with all three drugs suggest a direct inhibitory action on the caudate nucleus consistent with their proposed mechanism for treatment of Parkinson symptomatology. Head-turning appears to be a useful animal model for the development of new, specific anti-Parkinson drugs and for the study of possible mechanism(s) of action of existing drugs.

Amantadine↗
PubMed1974

T4-induced activity required for specific cleavage of a bacteriophage protein in vitro.

We have examined the acid-soluble products formed during incubation of labeled substrate protein from T4-infected cells with unlabeled phage-infected cell extracts. If the substrate protein is prepared from cells infected with a T4 mutant blocked in cleavage of phage head precursor proteins, the products formed in vitro include a peptide indistinguishable by several criteria from one of the T4 internal peptides. Denatured as well as undenatured protein can serve as the substrate for the formation of this peptide. As expected, this peptide is not formed if protein from either uninfected cells or cells infected with wild-type T4 is used as substrate. The formation of this peptide in vitro is dependent on a factor present in extracts of phage-infected cells but absent from extracts of uninfected cells.

Carbon Radioisotopes↗