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Biomedical subjects

J Golden

Publications and source records attributed to J Golden.

At least 73 records · Page 4Linked to original sources
PubMed1984

Birth.

Explore the source record for details and available documents.

Delivery, Obstetric↗
PubMed1983

Xanthine calculi in the Lesch-Nyhan syndrome.

Urinary tract calculi composed primarily of xanthine are rare in adults and children. However, there is risk of xanthine calculi formation in children with hereditary xanthinuria and children on xanthine oxidase inhibitor therapy for hyperuricemia. We describe the clinical presentation and management of 2 children with the Lesch-Nyhan syndrome (a congenital disorder of purine metabolism) and xanthine calculi. Little information has been available to direct the urologic management of such patients. We have based a plan for management upon our clinical experience with these children, as well as upon in vitro dissolution studies of the calculi. We have had some clinical success using an alternating acid/base dissolution therapy developed in the laboratory.

Adolescent↗
PubMed1983

Psychiatric aspects of male sexual dysfunction.

Sexual problems are highly prevalent in Western society. Most people in this culture are vulnerable to sexual concerns that may arise out of ignorance, cultural inhibitions, unrealistic expectations, and anxiety about performance. Because of the importance attached to sexual competence, the physician's efforts to improve the quality of a patient's life through prevention, treatment, or referral are worthwhile. Principles of therapy for psychiatric aspects of male sexual dysfunction tend to be simple and easily applied. Therapy is most effective when both partners are treated together. The physician stresses learning and encourages the couple to focus on pleasure rather than on performance. With minimal effort, the physician who is willing to try can do a great deal to help patients with sexual dysfunction.

Culture↗
PubMed1983

Bronchopulmonary dysplasia in the adult.

We describe 3 patients with adult respiratory distress syndrome that eventuated in a pathologic picture of honeycomb lung and a radiographic picture of variably cystic lung super-imposed on a background of diffuse alveolar infiltrates. All 3 patients had been treated with unusually high pressures of PEEP as well as high concentrations of oxygen for long periods of time (3 to 7 wk). Microscopically, the cystic structures in our patients appeared to be derived from collapse and fibrosis of the alveolar parenchyma with dilatation of the alveolar ducts. We suggest that this process is morphologically and radiographically similar to bronchopulmonary dysplasia as seen in the newborn.

Adolescent↗
PubMed1980

Effects of gas temperature and particulate water on rabbit lungs during ventilation.

Anesthetized young rabbits were ventilated for 6 hr at 20 cm H2O peak airway pressure using air nebulized with water at 22 degrees C (cold nebulized group, n = 11), at 36 degrees C (warm nebulized group, n = 11) and humidified air at 36 degrees C (warm humidified group, n = 10). Their biochemical status during ventilation and pulmonary morphology at autopsy were compared to those of ten control rabbits. Both nebulized groups had particulate water in the inspired air and water of condensation in the endotracheal tube. The rabbits ventilated with warm humidified air and the control group breathing spontaneously maintained their blood pressure and pHa within physiologic range. Rabbits ventilated with air nebulized with water at 22 and 36 degrees C had a significant decline in mean blood pressure (96 mm Hg leads to 61 mm Hg in cold nebulized and 91 mm Hg leads to 61 mm Hg in warm nebulized) and mean pHa (7.43 leads to 7.23 in cold nebulized and 7.42 leads to 7.31 in warm nebulized). All rabbits in the control and warm humidified groups survived the study whereas 9 of 22 in the nebulized groups died before completion of study (P < 0.005). Morphometric analysis revealed a significant increase in the mean vascular wall thickness in both nebulized groups of rabbits when compared to that in the control and warm humidified groups (P < 0.05). The cold nebulized group also had significantly less air space and correspondingly more interstitial thickness and intraalveolar edema (P < 0.05) compared to control and warm humidified groups. These findings of pulmonary parenchymal damage in rabbits ventilated with air containing particulate water and the greater degree of both physiologic and anatomic change evident in the cold nebulized animals suggest that particulate water and low inspired air temperature may contribute to the genesis of pulmonary damage during intermittent positive pressure ventilation.

Animals↗
PubMed1980

Effects of intermittent positive-pressure ventilation on lungs of normal rabbits.

We ventilated 10 healthy young rabbits with warm moist air at 20 cm H2O peak airway pressure and compared their pulmonary histology to that of 10 controls. The histological changes were analysed using the Leitz Texture Analysis System. Four hundred high-power fields (240 micrometers X 240 micrometers) were scanned from each section and the mean proportions of air space, interstitium and oedema determined. Calculated bicarbonate decreased significantly in both groups (P < 0.05); this was accompanied by a modest decrease in pHa in the ventilated group. The PaO2 and PaCO2 were maintained within the normal range. The blood pressure decreased in both groups. Seven of 10 ventilated rabbits had interstitial widening while only 1 of 10 controls had a similar lesion (chi 2 = 5.21, P = < 0.05). The area occupied by interstitium ranged from 26 to 46% (mean 37.6%) in controls and 18 to 81% (mean 45.4%) in ventilated rabbits. There was a lack of correlation between clinical and histopathological findings. While 6 of 10 ventilated rabbits had intra-alveolar oedema and a decrease in air space to less than 50% of total area, none developed hypoxaemia. Two of these 6 rabbits also had pHa less than 7.35 by the end of the study, yet all were clinically stable. These data indicate that intermittent partial-pressure ventilation with warm moist air may result in pulmonary parenchymal damage within 6 h in healthy rabbits.

Animals↗
PubMed1976

Plasma dopamine-beta-hydroxylase activity in phaeochromocytoma.

Plasma dopamine-beta-hydroxylase (DbetaH) activity, a marker of catecholamine secretion that occurs via exocytosis, was determined preoperatively in eight patients with phaeochromocytoma. Despite very elevated urinary catecholamine concentrations, mean plasma DbetaH activity was 32-6 +/- 3 u/l and was not significantly different from apparently healthy subjects. Seven days after surgery, one subject exhibited a 60% postoperative decrease of enzyme activity. These results suggest that diffusion across plasma membranes is the predominant mechanism of catecholamine release from phaeochromocytomas. The postoperative change in one patient suggests tumour heterogeneity and that exocytosis may contribute to the process of catecholamine release in some patients.

Catecholamines↗