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Biomedical subjects

J Goldberg

Publications and source records attributed to J Goldberg.

At least 343 records · Page 19Linked to original sources
PubMed1982

Granulomas do not affect postoperative recurrence rates in Crohn's disease.

Previous studies have reached disparate conclusions on the issue of whether or not granulomas confer any protection against recurrence of Crohn's disease after operation. In an attempt to resolve this controversy, we have examined postoperative recurrence rates in 102 patients with Crohn's disease. There were no differences in cumulative postoperative recurrence-free survival between the 53 patients with granulomas present in the resected specimens and the 49 patients without granulomas. It was concluded that the presence of granulomas in resected specimens of Crohn's disease exerts no independent influence on the rate of postoperative recurrence.

Crohn Disease↗
PubMed1982

Treatment of anemia in myeloproliferative disorders: a randomized study of fluoxymesterone v transfusions only.

Previously untreated patients who had anemia (hemoglobin level, less than or equal to 10 g/dL) caused by myelofibrosis (MF) (16 patients) or other myeloproliferative disorders (13 patients) were given the opportunity to participate in a prospective randomized study-to be treated either with 30 mg/day of oral fluoxymesterone and necessary transfusions or by transfusions alone. Of the 24 patients whose data could be evaluated, four (29%) of 14 responded well to fluoxymesterone therapy (hemoglobin level rise, of greater than 2 to greater than 10 g/dL and relief of symptoms of anemia), whereas, in the transfusion arm, there were no good "responders"; one of ten patients was a partial "remitter" (responder), with a rise in the hemoglobin level of 1 to 2 g/dL. All responders to fluoxymesterone therapy showed a 50% or more maximum uptake of injected ferrous citrate Fe 59 into RBC hemoglobin, whereas no nonresponder met this criterion. All responders had MF (marrow more than one third replaced by collagen). There was no significant difference in survival of patients in the two arms of the study.

Aged↗
PubMed1981

The development of acute myelomonocytic leukemia in a patient with acute lymphocytic leukemia.

A diagnosis of acute lymphocytic leukemia (ALL) was made from a peripheral blood and bone marrow specimen from a 59-year-old woman. Typical-appearing lymphoblasts were positive for periodic acid-Schiff (PAS) reaction, but negative for peroxidase, Sudan black B (SBB) and non-specific esterase (NSE) stains. Lymphoblasts failed to form non-immune rosettes and had no surface membrane immunoglobulins. However, lymphoblasts exhibited an "Ia-like" membrane antigen and markedly stimulated allogeneic lymphocytes in a mixed lymphocyte reaction (MLR). These cytochemical and immunologic studies were considered characteristic of null-cell subtype of ALL. Thirteen months later, the peripheral blood and bone marrow specimens contained numerous myelomonoblasts characterized by a weak or negative PAS stain and strongly positive peroxidase, SBB, and NSE reactions. Electron micrographs of the bone marrow suggested that the majority of leukemic cells were myelomonocytic and a minority of cells were lymphoblasts. In addition, myelomonoblasts in liquid cultures appeared to differentiate into mature macrophages. These data suggest the development of acute myelomonocyte leukemia in a previous case of ALL.

Bone Marrow↗
PubMed1981

A comparison of androgens for anemia in patients on hemodialysis.

To compare the erythropoietic effects of nandrolone decanoate, testosterone enanthate, oxymetholone, and fluoxymesterone, we performed a randomized clinical trial in patients with anemia who were receiving maintenance hemodialysis (the women were not given testosterone enanthate). After a control period of at least two months, patients received one of the drugs for six months and then returned to control status; a second and third drug were administered in a similar fashion. Seventy-seven patients completed the first drug period, 56 the second, and 35 the third. The response to nandrolone and testosterone enanthate, the two drugs given by injection, was clearly superior to the response to oxymetholone or fluoxymesterone, given by mouth, in terms of the percentage of patients responding and the mean rise in hematocrit. Approximately half the patients had an increase of at least 5 percentage points in hematocrit after an injectable androgen was given; more than half the women responded. Patients who required transfusions regularly and those who had bilateral nephrectomies did not respond.

Administration, Oral↗
PubMed1981

Plasmapheresis in refractory generalized myasthenia gravis.

A group of 16 patients with severe generalized myasthenia gravis (MG) (five with thymoma) that was resistant to anticholinesterases, thymectomy, and corticosteroids were treated by plasmapheresis. Twelve patients showed an excellent clinical response. Plasmapheresis is an effective treatment modality for many patients with severe generalized MG resistant to other forms of therapy. Unfortunately, the beneficial results are only transient and periodic plasmapheresis treatments are necessary.

Adult↗
PubMed1981

In-vitro differentiation of myeloblasts from a patient with acute myeloid leukemia.

Although acute myeloid leukemia is characterized by defective granulocytic maturation in vivo, blasts from an occasional patient will differentiate in vitro. Leukemic myeloblasts from a 49-year-old woman who had acute myeloid leukemia were suspended in liquid culture containing McCoy's 5A medium with 15% fetal calf serum. Conditioned medium, prepared from normal human peripheral blood adherent cells incubated with 2-mercaptoethanol in McCoy's 5A medium with 15% fetal calf serum, was added to the cultures at a concentration of 40%. Within six days, cellular differentiation to polymorphonuclear granulocytes was observed. These cells were capable of phagocytosis. Attempts to induce differentiation of leukemic cells in liquid culture will, it is hoped, contribute to the understanding of defective cellular maturation in this disease.

Cells, Cultured↗
PubMed1981

Factors affecting trauma center utilization in Illinois.

The Illinois Trauma System has served as a prototype for many of the advanced emergency medical services systems developed during the past decade. The Illinois Trauma Study uses a cross-sectional research design to assess the trauma patient utilization patterns at hospitals in Illinois. Data were collected from 33 Trauma Centers and 43 nonsystem hospitals for the time interval July 1973-June 1974. Results indicated that 45.5 per cent of patients admitted with specified trauma conditions were hospitalized at Trauma Centers. When adjustment is made for differences in the size of hospitals, a 50 per cent excess in patient capture is found at Trauma Centers. This excess utilization found in Trauma Centers for this sample of trauma victims was not found among all patients admitted to these hospitals. Factors found to be associated with high Trauma Center use are race (high use among nonwhites), injury severity, evening admission to hospital and vehicular injury. Also, approximately two thirds of trauma patients that were admitted to intensive care units or transferred from other hospitals were hospitalized at Trauma Centers.

Adolescent↗
PubMed1981

Clinical evaluation of high copper amalgam restorations.

A comprehensive clinical investigation of amalgam restorations was undertaken to evaluate the performance of "high copper' amalgams and the methods used to examine the marginal integrity of restorations. Six alloys, Aristaloy CR (A), Dispersalloy (D), Indiloy (I), an experimental "high copper' amalgam (E), Tytin (T), and New True Dentalloy (N) as a control, were randomly placed by four operators in 435 Class 1 and Class II restorations. Black and white 1 x photographs were taken at baseline, 6, 12 and 18 months and evaluated using the method described by Mahler & Marantz (1979). In addition, the U.S. Public Health Service system (Cvar & Ryge, 1971) was used at each recall. An analysis of variance based on photographic scoring indicated significant differences (P less than 0.05) among alloys at each recall. The use of Duncan's multiple range test resulted in two homogeneous subsets at 18 months: D, I, E and T, N, A. Six and 12 months recall data showed a close similarity in the rank order of the six alloys. The U.S.P.H.S. system showed no statistically significant differences between the alloys using the chi-square test, however, at each recall the rank order was comparable to that obtained with the photographic method.

Chemical Phenomena↗
PubMed1981

Cross-sectional clinical evaluation of recurrent enamel caries, restoration of marginal integrity, and oral hygiene status.

Both marginal quality and oral hygiene status have strong effects on the risk of recurrent caries. Although there was no statistically significant interaction between these two parameters in this study, the influence of each variable was dependent on its severity. There is a difference between the behavior or the likelihood of recurrent caries on occlusal surfaces as compared with smooth surfaces. On the smooth surfaces, there is a continued increased risk with decreasing marginal quality; the occlusal surfaces, however, show no change in vulnerability beyond a modified marginal quality score of 3. Variation in oral hygiene had a more pronounced effect on the probability of recurrent caries of restorations with moderate margin scores than it did on restorations with either very poor or very good cavosurface margins. This work further emphasizes the importance of technically good restorative care at the operative visit, which, coupled with conscientious oral hygiene, should have a positive effect on increasing the longevity of restorations and decreasing the need for replacement.

Adolescent↗
PubMed1981

Myeloid differentiation of human blood mononuclear cells in liquid culture.

Human blood mononuclear cells were prepared from peripheral blood or single donor plateletpheresis residues by depletion of adherent cells and T lymphocytes. In double-layer soft agar culture, 5 x 10(5) such cells yielded from 33 to 165 colonies. For liquid culture, these cells were suspended in McCoy's 5A medium with 15% fetal bovine serum and 0%, 20%, or 40% conditioned medium (CM) and incubated for up to 14 days at 37 degrees C in a humidified 5% CO2-95% air atmosphere. The number of cells in cultures with CM decreased about 0%-10%, while cell counts from cultures without CM decreased about 45%-65%. In cultures with CM, 5%-20% of the cells were classified as blasts after 3-5 days. After 7-11 days, blasts and promyelocytes comprised up to 53% of all cells. After 9-11 days, cells with specific granules and maturing nuclei comprised up to 56% of all cells. At 11 days, up to 66% of the cells contained peroxidase-positive granules. Cultures without CM contained no more than 5% blasts and promyelocytes and less than 5% maturing granulocytic cells. 3H-thymidine and Na235SO4 incorporation reached a peak at 3-5 days and at 5-11 days, respectively, in cells from cultures containing CM.

Cell Differentiation↗