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Biomedical subjects

J Golan

Publications and source records attributed to J Golan.

At least 19 recordsLinked to original sources
PubMed2003

Shabbes burn, a burn that occurs solely among Jewish orthodox children; due to accidental shower from overhead water heaters.

From January 1990 to January 2000, 35 children were treated in our department for Shabbes burn, a unique scald burn that occurred mainly among orthodox Jews during the Sabbath. A retrospective review was conducted to determine the extent of the problem, to understand the burn mechanism and to suggest a prevention program. A shower of hot water from the Sabbath heater is the cause of this burn. Among the Shabbes burn cases, 27 patients were female (77%) and 17 children (48%) were between 3 and 6 years old. It is suggested that this is a common burn that occurs among orthodox Jewish families and affects mainly females. Education programs using the media directed to the Jewish orthodox population have been conducted, this combined with redesigned of the heater, have reduced significantly the incidence of the burn as seen in our institute. However, even though efforts have been supported widely, there remains a need for educational and governmental regulations on a national level. This could aid orthodox Jews not only in Israel but globally, as well.

Accidents, Home↗
PubMed2000

The effect of propofol anaesthesia on oocyte fertilization and early embryo quality.

Propofol, frequently used for i.v. induction of anaesthesia in assisted reproduction procedures, has been suspected of damaging oocytes. Concentrations of propofol have recently been shown to increase in follicular fluid during oocyte retrieval. Our study was designed to assess whether exposure to increasing concentrations of propofol has a measurable effect on in-vitro fertilization, cleavage and embryo development. A cohort of 130 women underwent i.v. anaesthesia using propofol and fentanyl. Time of anaesthesia from i. v. injection of propofol was measured, as were the doses of the two drugs. In 32 women expected to have more than 15 oocytes retrieved, first, middle and last oocytes were cultured separately. The mean time from i.v. injection to first follicle aspiration was 200 s. The mean time for the aspiration of each additional oocyte was 17.6 s. In 10 out of 11 cases where follicular fluid concentrations of propofol were measured, there was an increase from the first to the last follicle, but no difference was found in the ratio of mature to immature oocytes. Nor were any differences found in fertilization, cleavage and embryo cell number. In so far as in-vitro development reflects embryo quality, we conclude that the time elapsed between retrieval of the first and last oocyte does not affect oocyte quality.

Anesthetics, Intravenous↗
PubMed1997

Individual implantation rate: proposal for a new index for evaluation of assisted reproduction results.

OBJECTIVE: To assess whether implantation in assisted reproductive technology (ART) cycles is a random event. DESIGN: Retrospective analysis of results. SETTING: Division for Reproductive Endocrinology and ART, Department of Obstetrics and Gynecology, Haemek Medical Center, Afula, Israel. PATIENT(S): A cohort of all cycles reaching ET from July 1, 1995, through June 30, 1996, and a cohort of all pregnancies recorded from January 1, 1995, through October 31, 1996. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Rate of multifetal pregnancy in relation to overall pregnancy rate. The number of gestational sacs observed by sonography, out of transferred embryos in conception cycles, was defined as the individual implantation rate. RESULT(S): Of 367 ETs, 75 (20.4%) yielded pregnancies, of which 31 (41%) were multifetal. Considering the mean number of embryos transferred (3.67), if implantation would have been random, multifetal gestation rate should have been only 14.8%, significantly less than the observed rate. In 110 pregnancies recorded between January 1995 and October 1996, individual implantation rate was 49.4% +/- 27.1% in intracytoplasmic sperm injection cycles compared with 40.5% +/- 20.4% in IVF cycles. CONCLUSION(S): Embryo implantation is not a random event. The index of individual implantation rate may help shed light on mechanisms underlying implantation.

Cohort Studies↗
PubMed1994

High origin of the ulnar and radial arteries in humans.

High division of the brachial artery was found in 4 human cadavers. In all cases the brachial artery divided into main branches within the medial bicipital sulcus. Both the ulnar and radial arteries descended within the sulcus to the elbow. In one case the musculocutaneous nerve was fused with the median nerve, giving off branches to the anterior group of arm muscles.

Brachial Plexus↗
PubMed1992

Pulmonary arteries dimensions and their dependences on the age, the height and body weight.

The studies were carried out on 100 right and 100 left lungs taken from human corpses of both sexes whose age varied from 1 month to 80 years. The material was divided into 3 age groups. The pulmonary arteries were injected 65% duracryl and then digested in sulfuric acid. The specimens obtained were examined to measurement the length and the diameter of the interlobar portion of the pulmonary arteries and their correlation indexes to the age, the length and the body weight. It was certain, that the pulmonary arteries dimensions still grows during man's extrafetal life; the diameter of the right pulmonary artery is usual greater than the left artery. The length of the interlobar portion of the right pulmonary artery varied in both sexes from 5 to 43 mm, and from 6 to 43 mm on the left pulmonary artery. The diameter of the some part of pulmonary arteries varied from 3 to 21 mm on the right side, and from 4.5 to 20 mm on the left side.

Aging↗
PubMed1988

Mechanical and histologic changes in canine vein grafts.

Mechanical and histological studies were performed on dog femoral veins after their implantation as grafts to bypass the ligated femoral arteries. The vein grafts dilated rapidly after implantation with 90% of maximum dilation occurring at 4 weeks. Both the native veins and the vein grafts were highly compliant up to 35-50 mm Hg, but were virtually nondistensible at higher pressures. When implanted with end-to-side anastomoses (end of vein to side of artery), the compliance of the anastomotic region resembled that of the artery rather than that of the vein. This was due to the distensibility of the artery at arterial pressure, as compared with the almost rigid vein. Histologic examination showed that intimal hyperplasia was greater after end-to-side anastomosis than after end-to-end anastomosis (P less than 0.05) and that this increased hyperplasia was reduced by treatment with aspirin and dipyridamole (P less than 0.05). By contrast, medial thickening was increased in all grafts compared with native veins (P less than 0.05), but was not different in end-to-end, end-to-side, and aspirin/dipyridamole-treated end-to-side grafts. These data suggest that intimal hyperplasia and medial thickening are separate responses to different stimuli.

Anastomosis, Surgical↗
PubMed1987

Arterial regeneration over polydioxanone prostheses in the rabbit.

We analyzed histologic, ultrastructural, and functional characteristics of rabbit aortic conduits regenerated over absorbable polydioxanone prostheses. Twenty-eight polydioxanone-elicited prosthesis/tissue complexes harvested two weeks to 12 months following implantation were analyzed grossly; photographed; sectioned for light, scanning, and transmission electron microscopy; and studied for compliance, bursting strength, and prostacyclin and thromboxane metabolite contents. No aortic-related deaths or hemorrhages occurred. Smooth regenerated conduits without stenoses were seen in 27 of 28 specimens, with one small aneurysm. Transprosthetic myofibroblast migration and proliferation paralleled the kinetics of macrophage-mediated prosthetic dissolution, which was consequently delayed compared with polyglycolic acid prostheses. Confluent endothelial-like luminal surfaces were present after two weeks. Progressive inner capsular thickening ended after three months at 420 micron. Ex vivo compliance curves resembled arterial elasticity. Regenerated tissue withstood 1200 mm Hg of systolic pressure, and 6-keto-prostaglandin F1 alpha to thromboxane B2 ratios did not differ from normal control specimens.

6-Ketoprostaglandin F1 alpha↗
PubMed1985

A new temporary synthetic skin substitute.

Eighteen months of experience with a new synthetic temporary skin substitute (Omiderm, Omikron Scientific Ltd., Rehovot, Israel) is presented. The substitute is a thin, transparent, flexible membrane. It is used when a biological dressing would otherwise have been used. Our experience consists of laboratory studies and 75 clinical cases including donor sites application, chronic wounds, ulcers, partial thickness and full thickness burns. The membrane is very elastic, permitting free movement and physiotherapy during the healing process. The material protects the wound and prevents either the accumulation of fluid under it or wound desiccation. It does not interfere with the normal healing process. It reduces pain, prevents bacterial invasion and is very easy to handle. Complications, such as haematoma formation or infection, were quite few. We recommend its use in routine daily practice.

Adolescent↗
PubMed1985

Extensive sebaceous nevus.

An unusual patient with extensive sebaceous nevus lesions is presented. The lesions were found on the scalp and face and extended into the mouth and anal region. They were associated with premature eruption of three teeth, a cleft in the secondary palate, and a deformation of the upper third of the right auricle. Skeletal deformities were not found. Neurologic defects were not present during first months. The definitive treatment was postponed because of the patient's young age and the magnitude of the lesions.

Face↗