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J Goedert

Publications and source records attributed to J Goedert.

68 records · Page 4Linked to original sources
PubMed1996

Tracking electronic claims growth.

Providers are submitting a growing majority of claims electronically. But physicians trail hospitals and pharmacies in the use of EDI.

Centers for Medicare and Medicaid Services, U.S.↗
PubMed1995

Measuring the movement to electronic claims.

Congressional inaction on health care reform during 1994 spelled a temporary halt to efforts to enact government mandates for the use of automated transactions. But even without the added pressure of government mandates, the steady shift to automated health care transactions continued during the year. Now that more of the nation's 1,500 health care payers and 700,000 providers are linked to regional and national electronic data interchange networks, more than one-third of all health care claims are transmitted electronically.

Computer Communication Networks↗
PubMed1994

The standards movement builds momentum.

The success of efforts to build health information networks and to implement computerized patient records will hinge on the development of standards for the electronic format and content of financial and clinical transactions. Without standards, sharing data among disparate systems will be extremely cumbersome, and drawing conclusions based on research will prove difficult. For years, several volunteer groups have been toiling to develop these standards. These efforts are beginning to pay off. This special report summarizes the latest trends in standards development. This series of stories includes an update on efforts to develop standard data sets for financial and administrative transactions; a guide to the jargon of health care electronic data interchange, an overview of efforts to speed the development of standards for computerized records; and a case study of a hospital implementing one set of clinical standards.

Clinical Medicine↗
PubMed1994

Automation a vital component of new Minnesota networks.

Faced with state legislation aimed at controlling health care cost increases, providers and payers in Minnesota are joining forces to form capitated managed care networks. Mandated universal claim forms, standards development and data reporting requirements will virtually require that the newly emerging networks make extensive use of electronic data interchange. The health care industry is watching closely to see whether the state's experience can serve as a model.

Computer Communication Networks↗
PubMed1992

HLA phenotype is a factor in determining rate of disease progression and outcome in HIV-1-infected individuals.

HLA allele frequencies were examined for possible association(s) with the rate of disease progression and with the disease outcome (AIDS diagnosis) in a population of HIV-1-infected individuals. Certain alleles were associated with the relative rate of CD4+ T-cell decline. Association of particular alleles with several disease outcomes associated with infection was also observed. It is important to keep these two aspects (disease progression, AIDS diagnosis) separate when studying HLA in the HIV-1-infected population. Alleles that may play a role in the rate of virus speed by effecting the immune response may be different from those found to be associated with a particular disease. We feel that the only truly informative data, in this regard, can be generated from a relative precise determination of the time of infection (to study disease progression) and adequate numbers of individuals with specific diseases to study specific disease association. If such data can be generated we will have a much better understanding of the pathogenetic process(es) of HIV-1 infection.

Alleles↗
PubMed1991

Common sequence in HIV 1 GP41 and HLA class II beta chains can generate crossreactive autoantibodies with immunosuppressive potential early in the course of HIV 1 infection.

We have previously reported the identification of highly conserved homologous regions located in the carboxy terminus of the HIV 1 gp41 (aa 837-844), and the amino-terminal of the beta chain of all human HLA class II antigens (aa 19-25). Murine monoclonal antibodies raised against synthetic peptides from these homologous regions bound not only to the isolated peptides, but also to "native" HLA class II molecules on cells. Screening of sera from HIV 1 infected individuals revealed high frequency of sera (35%) containing anti-class II crossreactive antibodies (CRAb), not only in AIDS patients, but also in early, asymptomatic patients. The CRAb containing sera caused potent inhibition of normal CD4-bearing cells' proliferative responses to tetanus toxoid in vitro. They could also kill class II bearing cells by ADCC. The possible contribution of these antibodies to the establishment of immunodeficiency state in HIV 1 infected individuals and/or to disease progression, was examined in two clinical studies: I. Asymptomatic patients were tested in parallel for their PBL responses to flu/tetanus, HLA alloantigens, and PHA (proliferation and IL2 production), and for the presence of anti-class II CRAb. About 50% of these patients showed a selective loss of their in vitro responses to recall antigens (flu/tetanus), which depend on CD4+ cells, while still responding to PHA and ALLO. Interestingly, positive correlation was found (P less than 0.001) between patients' lack of responsiveness to flu/tetanus and the presence in their sera of anti-class II CRAb. II. Retrospective study of HIV 1-infected hemophiliacs, suggest that patients with high titers of CRAb early in the disease progressed faster to full blown disease.

Amino Acid Sequence↗