Search PubMed⌕ Search

Biomedical subjects

J Giordano

Publications and source records attributed to J Giordano.

44 records · Page 3Linked to original sources
PubMed1987

Morphine- and ketocyclazocine-induced analgesia in the developing rat: differences due to type of noxious stimulus and body topography.

Patterns of morphine- and ketocyclazocine-induced analgesia in limb withdrawal and tail-flick tests of thermal and mechanical nociception were examined in the preweanling rat. In the forepaw test, morphine was more effective than ketocyclazocine with both thermal and mechanical stimuli. Both drugs first induced analgesia between 3 and 5 days of age. In the tail-flick test, ketocyclazocine-induced analgesia preceded morphine's effects against both thermal and mechanical stimuli by several days. Ketocyclazocine produced robust analgesia between 7 and 10 days of age, while the effects of morphine did not peak until day 14. In the hindpaw, morphine was more effective than ketocyclazocine against a higher intensity mechanical stimulus, while ketocyclazocine was more effective against a lower intensity mechanical stimulus. Morphine-induced analgesia was reversed by lower doses of naloxone than was ketocyclazocine-induced analgesia, regardless of body part tested, against all noxious stimuli. These findings demonstrate differences in morphine- and ketocyclazocine-induced analgesia that are dependent upon age, body topography, stimulus type and intensity and imply different physiologic roles of mu- and chi-opioid receptors in analgesia.

Age Factors↗
PubMed1981

In situ lobular carcinoma of the breast.

Nineteen patients who did not have mastectomy for in situ lobular carcinoma that was diagnosed by excisional biopsy were followed up for a period of seven to 21 years. In two patients, infiltrating carcinoma developed; each had mastectomies. They were followed up for 20 and 21 years. A third patient who previously had a mastectomy for infiltrating lobular carcinoma and who was being followed up for in situ lobular carcinoma in the contralateral breast died of metastatic disease. The remaining patients were found to be free of disease. These data support the concept that a small percentage (11%) of in situ lesions will progress to invasive tumors. Although mastectomy would seem to be the most prudent course, prolonged disease-free intervals were seen in patients who did not have mastectomy, suggesting close observation to be an alternative approach to this problem.

Breast Neoplasms↗
PubMed1978

Vena caval interruption in pulmonary hypertensive canines.

Massive pulmonary embolism regularly causes a reduction in systemic arterial pressure. This is accompanied by an increase in pulmonary arterial pressure. If right heart strain is sufficient, peripheral venous pressures also rise. Initial cardiac output and heart rate responses are variable, but with the progression of time, cardiac output almost uniformly falls. When either vena caval clipping or vena caval ligation are performed in the face ot these altered hemodynamics, there is a further reduction of systemic arterial pressure and cardiac output. After a period of 90 to 120 minutes, the effects of the two procedures appear to be equivalent. This is thought to be on the basis of opening of venous collateral pathways in the case of vena caval ligation. Therefore, when sufficient venous collaterals are present, the major determinant of the ultimate outcome is the impact of the embolus itself rather than the type of procedure used to interrupt the inferior vena cava.

Animals↗
PubMed1975

Fatal paralytic ileus complicating phenothiazine therapy.

The occurrence of fatal paralytic ileus with peritonitis in a patient receiving phenothiazines and an antiparkinsonian agent is described. Although sporadic reports of this complication have appeared, it has not been emphasized in the literature. Only by being alert to this problem can one hope to achieve earlier diagnosis and begin prompt and appropriate treatment.

Adult↗
PubMed1975

Effect of continuous positive pressure ventilation on cardiac output.

Ten mongrel dogs were placed on 5 and 10 cm. H20 of CPPV. Cardiac output, pulmonary vascular resistance and pleural pressures were measured. At 5 cm. H20/CPPV there was no significant change in cardiac output or pulmonary vascular resistance. At 10 cm. H20 CPPV cardiac output significantly decreased and pulmonary vascular resistance increased. The physiologic basis for these changes is discussed and related to the clinical situation.

Animals↗