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Biomedical subjects

J Gillon

Publications and source records attributed to J Gillon.

67 records · Page 4Linked to original sources
PubMed1981

Simultaneous onset of ulcerative colitis in the rectum and in a segment of colon used for colpopoiesis: report of a case.

A patient is described in whom a segment of colon used to construct an artificial vagina was therefore removed from intestinal continuity and was affected by typical idiopathic ulcerative colitis. The onset of disease was simultaneous in this loop of colon and in the rectum. There was no evidence of local infection. An increased ratio of IgE-plasma cells was found in both the mucosa of the grafted colon and that of the rectum, but anticolonic antibodies were not detected in the serum. After removal of the loop of colon used for colpopoiesis, the patient continued to suffer from distal proctocolitis for almost a year, but has since then maintained a stable remission without treatment. The etiology of ulcerative colitis is discussed, and attention is drawn to the unusual psychologic aspects of this case.

Adult↗
PubMed1981

Reduction of gastrointestinal protein loss by elemental diet in Crohn's disease of the small bowel.

Seven patients with hypoalbuminaemia and extensive jejunoileal Crohn's disease were treated with an elemental diet for 28 to 56 days. Over this time there was an increase in total plasma proteins from mean of 49.1 to 59.0 g/l and a mean rise in serum albumin from 20.7 to 30.0 g/l (P less than 0.05). In addition, there was a 47% mean reduction in plasma protein loss into the gastrointestinal tract and a rise in blood lymphocyte count in all patients (P less than 0.05). These results suggests that, as well as providing nutritional support, elemental diets reduce protein and lymphocyte loss from the diseased intestine.

Adult↗
PubMed1981

Corticosteroid treatment increases parasite numbers in murine giardiasis.

Corticosteroid therapy is known to be hazardous in patients with occult infection but the mechanism by which the host parasite relationship is altered by steroids is not known. We have used an intestinal protozoal parasite, Giardia muris, to examine the effects of corticosteroids on the number of parasites in the intestine in the course of a primary infection. A single injection of cortisone acetate, subcutaneously, one day before oral inoculation of CBA mice with 1000 cysts of Giardia muris, resulted in significantly higher trophozoite counts in animals studied at one, two, three, four, and eight weeks post-infection, when they were compared with saline injected controls. Recrudescence of occult infection was also achieved by cortisone acetate treatment of mice which had been infected with Giardia muris eight months previously. Clinical studies are required to establish if recrudescence of occult protozoal infection is an important cause of morbidity when immunosuppressive therapy is given to patients in areas where giardiasis is endemic.

Animals↗
PubMed1979

Pneumatosis coli and sigmoid volvulus: a report of 4 cases.

Pneumatosis coli is an uncommon disease which is frequently misdiagnosed and inappropriately treated. The condition can usually be managed conservatively but complications requiring surgical treatment are occasionally encountered. We describe 4 patients with pneumatosis coli and associated volvulus of the sigmoid colon. Some of the factors that may have contributed to pneumocyst formation in these 4 patients are discussed with reference to recent advances in our understanding of the pathogenesis of pneumatosis coli.

Adult↗
PubMed1979

Breath hydrogen in pneumatosis cystoides intestinalis.

Pneumatosis cystoides intestinalis (PCI) is an uncommon condition of unknown aetiology. Bacterial gas production may be an important aetiological factor, but experimental evidence in humans has been lacking. We have studied breath hydrogen excretion as an index of bacterial gas production in 12 patients with PCI and have shown that four out of five with demonstrable cysts produced unusually high levels of hydrogen while fasting. This abnormality has not been previously reported. One patient showed resolution of PCI after antibiotic treatment. These findings confirm the importance of bacterial gas production in the pathogenesis of PCI.

Adult↗
PubMedDate not supplied

Electrophysiologic effects of encainide following acute coronary occlusion in dogs.

Encainide, a benzanilide derivative, is a local anesthetic antiarrhythmic drug. To determine its effects on infarcted and normal tissue in situ, we infused encainide (1.0 mg/kg) for 15 min intravenously followed by 0.01 mg/kg/min for an additional 105 min in 8 adult open-chest, pentobarbital-anesthetized, atrially paced dogs after left anterior descending coronary occlusion. We monitored plasma concentration, blood pressure, and surface electrocardiogram (ECG). We determined conduction intervals from the onset of the QRS in the limb lead ECG to the major deflection of bipolar electrograms recorded in the infarcted and normal zones. We found that the blood pressure did not change significantly. Encainide did significantly prolong the atrial stimulus artifact-to-QRS interval and the QRS duration, as previously reported, and also prolonged intraventricular conduction intervals. In the infarcted zone, the drug prolonged conduction in both subendocardium and subepicardium, and prolongation was of somewhat greater magnitude in this zone than in the normal zone. Encainide prolonged the effective refractory period only in the infarcted zone (19 +/- 5 msec at peak; p less than 0.01). The above electrophysiologic effects may explain in part the previously demonstrated antiarrhythmic properties of this drug.

Anilides↗