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Biomedical subjects

J Gillen

Publications and source records attributed to J Gillen.

24 records · Page 2Linked to original sources
PubMed1983

Effect of helium on the ventilatory response to hypoxia under normocapnic and hypercapnic conditions.

We studied the effect of helium (He) on ventilatory (VI) responses to progressive isocapnic hypoxia. Accordingly, in normal male subjects (age 23-46), we compared hypoxic rebreathes using He as a carrier gas with those utilizing nitrogen (N2) as a carrier gas. When alveolar CO2 tension (PACO2) was maintained at 40 mm Hg, we noted no difference in VI responses to hypoxia between N2 and He trials. In contrast, when PACO2 was maintained at 50 mm Hg, VI responses to hypoxia during the He trials were consistently greater than those noted during the N2 experiments. These results indicate that substitution of He for N2 does not augment VI responses to normocapnic hypoxia; however, this substitution does enhance VI responses to hypercapnic hypoxia.

Adult↗
PubMed1982

Effects of respiratory gases on the frequency and duration of obstructive apneic episodes in a patient with the sleep apnea-hypersomnolence syndrome.

We studied the effects of hyperoxia and hypercapnia on obstructive apneic episodes (OAE) in a 39-year-old male with the sleep apnea and hypersomnolence syndrome (SAHS). While inspiring room air, our patient spent approximately 50% of his non-REM sleep time in OAE. When the inspired gas was changed to 100% oxygen, the frequency of the OAE decreased slightly, but a statistically significant increase in the duration of each episode was noted. Additionally, a CO2 rebreathe under hyperoxic conditions was carried out during non-REM sleep; no OAE were noted during this rebreathe. Therefore, this latter observation suggests that hypercapnia under hyperoxic conditions may reduce the frequency of OAE in patients with the SAHS.

Adult↗
PubMed1982

Vitamin status in patients on chronic anticonvulsant therapy.

Vitamin levels in blood were estimated in 146 epileptics, aged 20-40 years. Compared to healthy subjects, no higher risk rates of a vitamin deficiency were found in epileptics for vitamins B1, B12, A, C, E and beta-carotene. alpha EGR was elevated only in epileptic females, alpha EGOT in epileptic males, indicating a higher risk of a vitamin B2 and B6 deficiency in these groups. Markedly reduced levels of folate, 25-hydroxy-cholecalciferol, and biotin were found in the epileptics; folate and biotin levels showed a significant negative correlation with the total amount and the average daily dose of anticonvulsants administered.

Adult↗